Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study

During orthodontic tooth movement, the early response of periodontal tissues to mechanical stress is an acute inflammatory reaction. Mechanical stress from orthodontic appliances is believed to induce cells in the periodontal ligament (PDL) to form biologically active substances, such as enzymes and...

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Main Authors:	Abu Bakar, Noraini, Mustafa Al-Ahmad, Basma Ezzat, Hilal Abbood Al-Bayati, Lina, Kamil, Wisam Alaa
Format:	Conference or Workshop Item
Language:	English English
Published:	2016
Subjects:	RK Dentistry
Online Access:	http://irep.iium.edu.my/49656/ http://irep.iium.edu.my/49656/ http://irep.iium.edu.my/49656/4/IMG_20160212_0003.pdf http://irep.iium.edu.my/49656/9/Sri_Lanka.pdf

id	iium-49656
recordtype	eprints
spelling	iium-496562018-05-24T01:15:27Z http://irep.iium.edu.my/49656/ Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study Abu Bakar, Noraini Mustafa Al-Ahmad, Basma Ezzat Hilal Abbood Al-Bayati, Lina Kamil, Wisam Alaa RK Dentistry During orthodontic tooth movement, the early response of periodontal tissues to mechanical stress is an acute inflammatory reaction. Mechanical stress from orthodontic appliances is believed to induce cells in the periodontal ligament (PDL) to form biologically active substances, such as enzymes and cytokines, responsible for connective tissue remodeling (Nishijima Y et al 2006). Leptin, a polypeptide hormone has been classified as a cytokine (Zhang et al 1994). Earlier findings suggested that leptin does play a significant role in bone formation by its direct effect on osteoblasts (Alparslan et al 2010). This pilot study aimed to study leptin in saliva and its association with tooth movement during initial orthodontic alignment. To determine if there is any difference in saliva leptin level before and after orthodontic alignment Ten orthodontic patients (7 girls and 3 boys; mean age, 16.76 ± 1.1 years) with crowding (up to 5mm) that required orthodontic fixed appliances, on a non-extraction basis as part of the treatment plan, were recruited in this longitudinal study. Orthodontic study models were constructed at baseline and at 6-weeks after orthodontic treatment commenced. Full fixed orthodontic appliances with initial 0.014” Nickel Titanium archwire placed. The amount of crowding was measured, before and after initial alignment. Unstimulated morning saliva sample were collected at all visits, after at least an 8-hour period of fasting and no-toothbrushing. The samples were tested using Leptin Abnova LEP Human ELISA kit and subsequently analyzed. Leptin concentration in saliva was significantly decreased in a time-dependant manner (p<0.001), from before orthodontic treatment (7016.45±425.15 pg/mL) and 6 weeks after bond-up (4901.92±238.64 pg/mL). Leptin concentration in saliva is decreased during orthodontic tooth movement in initial alignment stage. 2016 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/49656/4/IMG_20160212_0003.pdf application/pdf en http://irep.iium.edu.my/49656/9/Sri_Lanka.pdf Abu Bakar, Noraini and Mustafa Al-Ahmad, Basma Ezzat and Hilal Abbood Al-Bayati, Lina and Kamil, Wisam Alaa (2016) Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study. In: International Orthodontic Conference SLOS 2016, 4-8 Feb 2016, Colombo,Sri Lanka. (Unpublished) http://www.srilankanentertainer.com/sri-lanka-events/international-orthodontic-conference-slos-2016-sri-lanka/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RK Dentistry
spellingShingle	RK Dentistry Abu Bakar, Noraini Mustafa Al-Ahmad, Basma Ezzat Hilal Abbood Al-Bayati, Lina Kamil, Wisam Alaa Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study
description	During orthodontic tooth movement, the early response of periodontal tissues to mechanical stress is an acute inflammatory reaction. Mechanical stress from orthodontic appliances is believed to induce cells in the periodontal ligament (PDL) to form biologically active substances, such as enzymes and cytokines, responsible for connective tissue remodeling (Nishijima Y et al 2006). Leptin, a polypeptide hormone has been classified as a cytokine (Zhang et al 1994). Earlier findings suggested that leptin does play a significant role in bone formation by its direct effect on osteoblasts (Alparslan et al 2010). This pilot study aimed to study leptin in saliva and its association with tooth movement during initial orthodontic alignment. To determine if there is any difference in saliva leptin level before and after orthodontic alignment Ten orthodontic patients (7 girls and 3 boys; mean age, 16.76 ± 1.1 years) with crowding (up to 5mm) that required orthodontic fixed appliances, on a non-extraction basis as part of the treatment plan, were recruited in this longitudinal study. Orthodontic study models were constructed at baseline and at 6-weeks after orthodontic treatment commenced. Full fixed orthodontic appliances with initial 0.014” Nickel Titanium archwire placed. The amount of crowding was measured, before and after initial alignment. Unstimulated morning saliva sample were collected at all visits, after at least an 8-hour period of fasting and no-toothbrushing. The samples were tested using Leptin Abnova LEP Human ELISA kit and subsequently analyzed. Leptin concentration in saliva was significantly decreased in a time-dependant manner (p<0.001), from before orthodontic treatment (7016.45±425.15 pg/mL) and 6 weeks after bond-up (4901.92±238.64 pg/mL). Leptin concentration in saliva is decreased during orthodontic tooth movement in initial alignment stage.
format	Conference or Workshop Item
author	Abu Bakar, Noraini Mustafa Al-Ahmad, Basma Ezzat Hilal Abbood Al-Bayati, Lina Kamil, Wisam Alaa
author_facet	Abu Bakar, Noraini Mustafa Al-Ahmad, Basma Ezzat Hilal Abbood Al-Bayati, Lina Kamil, Wisam Alaa
author_sort	Abu Bakar, Noraini
title	Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study
title_short	Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study
title_full	Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study
title_fullStr	Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study
title_full_unstemmed	Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study
title_sort	saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study
publishDate	2016
url	http://irep.iium.edu.my/49656/ http://irep.iium.edu.my/49656/ http://irep.iium.edu.my/49656/4/IMG_20160212_0003.pdf http://irep.iium.edu.my/49656/9/Sri_Lanka.pdf
first_indexed	2023-09-18T21:10:11Z
last_indexed	2023-09-18T21:10:11Z
_version_	1777411200265486336

Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study

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