Study of Beta 2-Adrenergic Receptor Polymorphisms among Hypertensives

Aims: The Arg16Gly and the Gln27Glu polymorphisms in the gene for the beta2-adrenergic receptor (beta2AR) have been linked to the hypertensive status. The aim of the present study was to assess the association between ;22AR polymorphisms and hypertension. Methods: In case control study, 100 unrelate...

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Main Authors:	Atia, Ahmad Elbadry, Ku Zaifah, Norsidah, Abdullah, Nor Zamzila, Mokhtaar, Rafidah Hanim, Md Aris, Mohd Aznan, Draman, Samsul, A.Talib, Norlelawati
Format:	Conference or Workshop Item
Language:	English English
Published:	2010
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/4972/ http://irep.iium.edu.my/4972/1/iCast_Poster_2010.pdf http://irep.iium.edu.my/4972/4/ICAST_ElBadri_2010.pdf

id	iium-4972
recordtype	eprints
spelling	iium-49722015-11-11T01:35:21Z http://irep.iium.edu.my/4972/ Study of Beta 2-Adrenergic Receptor Polymorphisms among Hypertensives Atia, Ahmad Elbadry Ku Zaifah, Norsidah Abdullah, Nor Zamzila Mokhtaar, Rafidah Hanim Md Aris, Mohd Aznan Draman, Samsul A.Talib, Norlelawati R Medicine (General) Aims: The Arg16Gly and the Gln27Glu polymorphisms in the gene for the beta2-adrenergic receptor (beta2AR) have been linked to the hypertensive status. The aim of the present study was to assess the association between ;22AR polymorphisms and hypertension. Methods: In case control study, 100 unrelated patients (50 hypertensive and 50 matched controls) were analyzed for the Arg16Gly and the Gln27Glu polymorphisms by restriction fragment length polymorphism- polymerase chain reaction assay analysis. Results: The genotypes frequencies of the genotypes of the 100 individuals enrolled in the study were: Arg16 (24%); Arg16Gly (45%); Gly16 (31%); Gln27 (83%); Gln27Glu (15%), and Glu27 (2%). The present study found no association between the 2 SNPs, Arg16Gly and Gln27Glu of beta2 adrenergic receptor gene with either hypertensive status or elevated blood pressure. (P value is 0.78 (odds ratio=0.81) and 0.37 (odds ratio=1.81) for Agr16Gly, Gln27Glu respectively). Conclusion: these finding suggest that B2AR SNPs tested are unlikely to confer genetic susceptibility for hypertension status in our population samples 2010-11-26 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/4972/1/iCast_Poster_2010.pdf application/pdf en http://irep.iium.edu.my/4972/4/ICAST_ElBadri_2010.pdf Atia, Ahmad Elbadry and Ku Zaifah, Norsidah and Abdullah, Nor Zamzila and Mokhtaar, Rafidah Hanim and Md Aris, Mohd Aznan and Draman, Samsul and A.Talib, Norlelawati (2010) Study of Beta 2-Adrenergic Receptor Polymorphisms among Hypertensives. In: 3rd International Conference on Advancement in Science and Technology (ICAST), 26-29 Nov 2010, Vistana Hotel, Kuantan.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Atia, Ahmad Elbadry Ku Zaifah, Norsidah Abdullah, Nor Zamzila Mokhtaar, Rafidah Hanim Md Aris, Mohd Aznan Draman, Samsul A.Talib, Norlelawati Study of Beta 2-Adrenergic Receptor Polymorphisms among Hypertensives
description	Aims: The Arg16Gly and the Gln27Glu polymorphisms in the gene for the beta2-adrenergic receptor (beta2AR) have been linked to the hypertensive status. The aim of the present study was to assess the association between ;22AR polymorphisms and hypertension. Methods: In case control study, 100 unrelated patients (50 hypertensive and 50 matched controls) were analyzed for the Arg16Gly and the Gln27Glu polymorphisms by restriction fragment length polymorphism- polymerase chain reaction assay analysis. Results: The genotypes frequencies of the genotypes of the 100 individuals enrolled in the study were: Arg16 (24%); Arg16Gly (45%); Gly16 (31%); Gln27 (83%); Gln27Glu (15%), and Glu27 (2%). The present study found no association between the 2 SNPs, Arg16Gly and Gln27Glu of beta2 adrenergic receptor gene with either hypertensive status or elevated blood pressure. (P value is 0.78 (odds ratio=0.81) and 0.37 (odds ratio=1.81) for Agr16Gly, Gln27Glu respectively). Conclusion: these finding suggest that B2AR SNPs tested are unlikely to confer genetic susceptibility for hypertension status in our population samples
format	Conference or Workshop Item
author	Atia, Ahmad Elbadry Ku Zaifah, Norsidah Abdullah, Nor Zamzila Mokhtaar, Rafidah Hanim Md Aris, Mohd Aznan Draman, Samsul A.Talib, Norlelawati
author_facet	Atia, Ahmad Elbadry Ku Zaifah, Norsidah Abdullah, Nor Zamzila Mokhtaar, Rafidah Hanim Md Aris, Mohd Aznan Draman, Samsul A.Talib, Norlelawati
author_sort	Atia, Ahmad Elbadry
title	Study of Beta 2-Adrenergic Receptor Polymorphisms among Hypertensives
title_short	Study of Beta 2-Adrenergic Receptor Polymorphisms among Hypertensives
title_full	Study of Beta 2-Adrenergic Receptor Polymorphisms among Hypertensives
title_fullStr	Study of Beta 2-Adrenergic Receptor Polymorphisms among Hypertensives
title_full_unstemmed	Study of Beta 2-Adrenergic Receptor Polymorphisms among Hypertensives
title_sort	study of beta 2-adrenergic receptor polymorphisms among hypertensives
publishDate	2010
url	http://irep.iium.edu.my/4972/ http://irep.iium.edu.my/4972/1/iCast_Poster_2010.pdf http://irep.iium.edu.my/4972/4/ICAST_ElBadri_2010.pdf
first_indexed	2023-09-18T20:13:24Z
last_indexed	2023-09-18T20:13:24Z
_version_	1777407628296585216

Study of Beta 2-Adrenergic Receptor Polymorphisms among Hypertensives

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