Rate of remission after radio-ablative iodine therapy for thyrotoxicosis: The University Kebangsaan Malaysia Medical Centre (UKMMC) experience

Rate of remission after radio-ablative iodine therapy for thyrotoxicosis: The University Kebangsaan Malaysia Medical Centre (UKMMC) experience

Objectives: To describe the rate of remission of thyrotoxicosis after radioablative iodine-131 (RAI) therapy. Methods: This was a retrospective review of 84 thyrotoxic patients who received RAI in the year 2011/2012. Their blood investigations prior and post-RAI therapy were reviewed. Data were...

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Main Authors: Shahar, Mohammad Arif, Omar, Ahmad Marzuki, AbAziz, Aini, Rajoo, Subashini, Loh, Huai Heng, Ooi, Chew Peng, Wan Seman, Wan Juani, Omar, Mohd Rahman, A Wahab, Norasyikin, Zainuddin, Suehazlyn, Mustafa, Norlaila, Sukor, Norlela, Kamaruddin, Nor Azmi
Format: Article
Language:English
Published: Malaysian Endocrine and Metabolic Society 2014
Subjects:
R Medicine (General)
RC Internal medicine
Online Access:http://irep.iium.edu.my/50091/
http://irep.iium.edu.my/50091/
http://irep.iium.edu.my/50091/1/OP-45.pdf
id iium-50091
recordtype eprints
spelling iium-500912016-07-15T02:53:15Z http://irep.iium.edu.my/50091/ Rate of remission after radio-ablative iodine therapy for thyrotoxicosis: The University Kebangsaan Malaysia Medical Centre (UKMMC) experience Shahar, Mohammad Arif Omar, Ahmad Marzuki AbAziz, Aini Rajoo, Subashini Loh, Huai Heng Ooi, Chew Peng Wan Seman, Wan Juani Omar, Mohd Rahman A Wahab, Norasyikin Zainuddin, Suehazlyn Mustafa, Norlaila Sukor, Norlela Kamaruddin, Nor Azmi R Medicine (General) RC Internal medicine Objectives: To describe the rate of remission of thyrotoxicosis after radioablative iodine-131 (RAI) therapy. Methods: This was a retrospective review of 84 thyrotoxic patients who received RAI in the year 2011/2012. Their blood investigations prior and post-RAI therapy were reviewed. Data were analyzed using SPSS 19. Results: Eighty-four patient received RAI therapy in 2011/2012 and was followed-up till March 2014. The mean age of the patients was 45.8 ± 12.8 years. Majority (57.1%) received 12 mCi, 19% received 15 mCi and 23.8% received lower dose (10 mCi) of RAI. Mean thyroxine level prior to RAI was 28.3 ± 12.0 pmol/L, and majority (77.8%) had suppressed TSH (<0.01 mIU/L) and 22.2% had low but detectable TSH (0.01-0.3 mIU/L). Fourtyfive percent (44.9%) remained hyperthyroid at 6 months post RAI (44.2% have suppressed TSH, 55.8% have detectable low TSH). Among those who went into remission at 6 months, 31.6% were euthyroid and 68.4% were hypothyroid. At 12 months 51.2% of patient goes into remission where 39.5% of them were euthyroid and 60.5% were hypothyroid. Half of the patient went into remission by 5 months post RAI therapy. By 24 months, 81.9% had gone into remission. Conclusions: The percentage of remission after RAI therapy at our centre increases with duration. By 24 months RAI induces remission in about 82% of patients Malaysian Endocrine and Metabolic Society 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/50091/1/OP-45.pdf Shahar, Mohammad Arif and Omar, Ahmad Marzuki and AbAziz, Aini and Rajoo, Subashini and Loh, Huai Heng and Ooi, Chew Peng and Wan Seman, Wan Juani and Omar, Mohd Rahman and A Wahab, Norasyikin and Zainuddin, Suehazlyn and Mustafa, Norlaila and Sukor, Norlela and Kamaruddin, Nor Azmi (2014) Rate of remission after radio-ablative iodine therapy for thyrotoxicosis: The University Kebangsaan Malaysia Medical Centre (UKMMC) experience. Journal of Endocrinology and Metabolism, 4 (1(Sup)). p. 18. ISSN 2229-9572 http://www.jmems.org/index.php/jmems/issue/view/5
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic R Medicine (General)
RC Internal medicine
spellingShingle R Medicine (General)
RC Internal medicine
Shahar, Mohammad Arif
Omar, Ahmad Marzuki
AbAziz, Aini
Rajoo, Subashini
Loh, Huai Heng
Ooi, Chew Peng
Wan Seman, Wan Juani
Omar, Mohd Rahman
A Wahab, Norasyikin
Zainuddin, Suehazlyn
Mustafa, Norlaila
Sukor, Norlela
Kamaruddin, Nor Azmi
Rate of remission after radio-ablative iodine therapy for thyrotoxicosis: The University Kebangsaan Malaysia Medical Centre (UKMMC) experience
description Objectives: To describe the rate of remission of thyrotoxicosis after radioablative iodine-131 (RAI) therapy. Methods: This was a retrospective review of 84 thyrotoxic patients who received RAI in the year 2011/2012. Their blood investigations prior and post-RAI therapy were reviewed. Data were analyzed using SPSS 19. Results: Eighty-four patient received RAI therapy in 2011/2012 and was followed-up till March 2014. The mean age of the patients was 45.8 ± 12.8 years. Majority (57.1%) received 12 mCi, 19% received 15 mCi and 23.8% received lower dose (10 mCi) of RAI. Mean thyroxine level prior to RAI was 28.3 ± 12.0 pmol/L, and majority (77.8%) had suppressed TSH (<0.01 mIU/L) and 22.2% had low but detectable TSH (0.01-0.3 mIU/L). Fourtyfive percent (44.9%) remained hyperthyroid at 6 months post RAI (44.2% have suppressed TSH, 55.8% have detectable low TSH). Among those who went into remission at 6 months, 31.6% were euthyroid and 68.4% were hypothyroid. At 12 months 51.2% of patient goes into remission where 39.5% of them were euthyroid and 60.5% were hypothyroid. Half of the patient went into remission by 5 months post RAI therapy. By 24 months, 81.9% had gone into remission. Conclusions: The percentage of remission after RAI therapy at our centre increases with duration. By 24 months RAI induces remission in about 82% of patients
format Article
author Shahar, Mohammad Arif
Omar, Ahmad Marzuki
AbAziz, Aini
Rajoo, Subashini
Loh, Huai Heng
Ooi, Chew Peng
Wan Seman, Wan Juani
Omar, Mohd Rahman
A Wahab, Norasyikin
Zainuddin, Suehazlyn
Mustafa, Norlaila
Sukor, Norlela
Kamaruddin, Nor Azmi
author_facet Shahar, Mohammad Arif
Omar, Ahmad Marzuki
AbAziz, Aini
Rajoo, Subashini
Loh, Huai Heng
Ooi, Chew Peng
Wan Seman, Wan Juani
Omar, Mohd Rahman
A Wahab, Norasyikin
Zainuddin, Suehazlyn
Mustafa, Norlaila
Sukor, Norlela
Kamaruddin, Nor Azmi
author_sort Shahar, Mohammad Arif
title Rate of remission after radio-ablative iodine therapy for thyrotoxicosis: The University Kebangsaan Malaysia Medical Centre (UKMMC) experience
title_short Rate of remission after radio-ablative iodine therapy for thyrotoxicosis: The University Kebangsaan Malaysia Medical Centre (UKMMC) experience
title_full Rate of remission after radio-ablative iodine therapy for thyrotoxicosis: The University Kebangsaan Malaysia Medical Centre (UKMMC) experience
title_fullStr Rate of remission after radio-ablative iodine therapy for thyrotoxicosis: The University Kebangsaan Malaysia Medical Centre (UKMMC) experience
title_full_unstemmed Rate of remission after radio-ablative iodine therapy for thyrotoxicosis: The University Kebangsaan Malaysia Medical Centre (UKMMC) experience
title_sort rate of remission after radio-ablative iodine therapy for thyrotoxicosis: the university kebangsaan malaysia medical centre (ukmmc) experience
publisher Malaysian Endocrine and Metabolic Society
publishDate 2014
url http://irep.iium.edu.my/50091/
http://irep.iium.edu.my/50091/
http://irep.iium.edu.my/50091/1/OP-45.pdf
first_indexed 2023-09-18T21:10:46Z
last_indexed 2023-09-18T21:10:46Z
_version_ 1777411237461622784

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