Continuous versus intermittent beta-lactam infusion in severe sepsis: a meta-analysis of individual patient data from randomized trials

Measurements and Main Results: We identified three randomized controlled trials in which researchers recruited a total of 632 patients with severe sepsis. The two groups were well balanced in terms of age, sex, and illness severity. The rates of hospital mortality and clinical cure for the continuou...

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Main Authors:	Roberts, Jason A., Abdul Aziz, Mohd. Hafiz, Davis, Joshua S., Dulhunty, Joel M., Cotta, Menino O., Myburgh, John, Bellomo, Rinaldo, Lipman, Jeffrey
Format:	Article
Language:	English English English
Published:	American Thoracic Society 2016
Subjects:	R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/50325/ http://irep.iium.edu.my/50325/ http://irep.iium.edu.my/50325/10/roberts2016.pdf http://irep.iium.edu.my/50325/16/50325_Continuous%20versus%20intermittent%20beta-lactam_SCOPUS.pdf http://irep.iium.edu.my/50325/22/50325_Continuous%20versus%20intermittent%20beta-lactam%20infusion%20in%20severe%20sepsis_WoS.pdf

id	iium-50325
recordtype	eprints
spelling	iium-503252017-10-03T06:48:22Z http://irep.iium.edu.my/50325/ Continuous versus intermittent beta-lactam infusion in severe sepsis: a meta-analysis of individual patient data from randomized trials Roberts, Jason A. Abdul Aziz, Mohd. Hafiz Davis, Joshua S. Dulhunty, Joel M. Cotta, Menino O. Myburgh, John Bellomo, Rinaldo Lipman, Jeffrey R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica Measurements and Main Results: We identified three randomized controlled trials in which researchers recruited a total of 632 patients with severe sepsis. The two groups were well balanced in terms of age, sex, and illness severity. The rates of hospital mortality and clinical cure for the continuous versus intermittent infusion groups were 19.6% versus 26.3% (relative risk, 0.74; 95% confidence interval, 0.56–1.00; P = 0.045) and 55.4% versus 46.3% (relative risk, 1.20; 95% confidence interval, 1.03–1.40; P = 0.021), respectively. In a multivariable model, intermittent β-lactam administration, higher Acute Physiology and Chronic Health Evaluation II score, use of renal replacement therapy, and infection by nonfermenting gram-negative bacilli were significantly associated with hospital mortality. Continuous β-lactam administration was not independently associated with clinical cure. Conclusions: Compared with intermittent dosing, administration of β-lactam antibiotics by continuous infusion in critically ill patients with severe sepsis is associated with decreased hospital mortality. American Thoracic Society 2016-09-15 Article PeerReviewed application/pdf en http://irep.iium.edu.my/50325/10/roberts2016.pdf application/pdf en http://irep.iium.edu.my/50325/16/50325_Continuous%20versus%20intermittent%20beta-lactam_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/50325/22/50325_Continuous%20versus%20intermittent%20beta-lactam%20infusion%20in%20severe%20sepsis_WoS.pdf Roberts, Jason A. and Abdul Aziz, Mohd. Hafiz and Davis, Joshua S. and Dulhunty, Joel M. and Cotta, Menino O. and Myburgh, John and Bellomo, Rinaldo and Lipman, Jeffrey (2016) Continuous versus intermittent beta-lactam infusion in severe sepsis: a meta-analysis of individual patient data from randomized trials. American Journal of Respiratory and Critical Care Medicine, 194 (6). pp. 681-691. ISSN 1073-449X http://www.atsjournals.org/doi/abs/10.1164/rccm.201601-0024OC?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica
spellingShingle	R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica Roberts, Jason A. Abdul Aziz, Mohd. Hafiz Davis, Joshua S. Dulhunty, Joel M. Cotta, Menino O. Myburgh, John Bellomo, Rinaldo Lipman, Jeffrey Continuous versus intermittent beta-lactam infusion in severe sepsis: a meta-analysis of individual patient data from randomized trials
description	Measurements and Main Results: We identified three randomized controlled trials in which researchers recruited a total of 632 patients with severe sepsis. The two groups were well balanced in terms of age, sex, and illness severity. The rates of hospital mortality and clinical cure for the continuous versus intermittent infusion groups were 19.6% versus 26.3% (relative risk, 0.74; 95% confidence interval, 0.56–1.00; P = 0.045) and 55.4% versus 46.3% (relative risk, 1.20; 95% confidence interval, 1.03–1.40; P = 0.021), respectively. In a multivariable model, intermittent β-lactam administration, higher Acute Physiology and Chronic Health Evaluation II score, use of renal replacement therapy, and infection by nonfermenting gram-negative bacilli were significantly associated with hospital mortality. Continuous β-lactam administration was not independently associated with clinical cure. Conclusions: Compared with intermittent dosing, administration of β-lactam antibiotics by continuous infusion in critically ill patients with severe sepsis is associated with decreased hospital mortality.
format	Article
author	Roberts, Jason A. Abdul Aziz, Mohd. Hafiz Davis, Joshua S. Dulhunty, Joel M. Cotta, Menino O. Myburgh, John Bellomo, Rinaldo Lipman, Jeffrey
author_facet	Roberts, Jason A. Abdul Aziz, Mohd. Hafiz Davis, Joshua S. Dulhunty, Joel M. Cotta, Menino O. Myburgh, John Bellomo, Rinaldo Lipman, Jeffrey
author_sort	Roberts, Jason A.
title	Continuous versus intermittent beta-lactam infusion in severe sepsis: a meta-analysis of individual patient data from randomized trials
title_short	Continuous versus intermittent beta-lactam infusion in severe sepsis: a meta-analysis of individual patient data from randomized trials
title_full	Continuous versus intermittent beta-lactam infusion in severe sepsis: a meta-analysis of individual patient data from randomized trials
title_fullStr	Continuous versus intermittent beta-lactam infusion in severe sepsis: a meta-analysis of individual patient data from randomized trials
title_full_unstemmed	Continuous versus intermittent beta-lactam infusion in severe sepsis: a meta-analysis of individual patient data from randomized trials
title_sort	continuous versus intermittent beta-lactam infusion in severe sepsis: a meta-analysis of individual patient data from randomized trials
publisher	American Thoracic Society
publishDate	2016
url	http://irep.iium.edu.my/50325/ http://irep.iium.edu.my/50325/ http://irep.iium.edu.my/50325/10/roberts2016.pdf http://irep.iium.edu.my/50325/16/50325_Continuous%20versus%20intermittent%20beta-lactam_SCOPUS.pdf http://irep.iium.edu.my/50325/22/50325_Continuous%20versus%20intermittent%20beta-lactam%20infusion%20in%20severe%20sepsis_WoS.pdf
first_indexed	2023-09-18T21:11:08Z
last_indexed	2023-09-18T21:11:08Z
_version_	1777411259742814208

Continuous versus intermittent beta-lactam infusion in severe sepsis: a meta-analysis of individual patient data from randomized trials

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