Blood-pressure lowering in intermediate-risk persons without cardiovascular disease
Antihypertensive therapy reduces the risk of cardiovascular events among high-risk persons and among those with a systolic blood pressure of 160 mm Hg or higher,but its role in persons at intermediate risk and with lower blood pressure is unclear In one comparison from a 2-by-2 factorial trial, w...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Massachusetts Medical Society
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/50354/ http://irep.iium.edu.my/50354/ http://irep.iium.edu.my/50354/ http://irep.iium.edu.my/50354/1/Blood-Pressure_Lowering_in_Intermediate-.pdf http://irep.iium.edu.my/50354/2/DR_AZNAN.pdf |
| Summary: | Antihypertensive therapy reduces the risk of cardiovascular events among high-risk persons and among those with a systolic blood pressure of 160 mm Hg or higher,but its role in persons at intermediate risk and with lower blood pressure is unclear
In one comparison from a 2-by-2 factorial trial, we randomly assigned 12,705 participants at intermediate risk who did not have cardiovascular disease to receive either candesartan at a dose of 16 mg per day plus hydrochlorothiazide at a dose of 12.5 mg per day or placebo. The first coprimary outcome was the composite of
death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke; the second coprimary outcome additionally included resuscitated cardiac arrest, heart failure, and revascularization. The median follow-up was 5.6 years. |
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