A meta-analysis on the accuracy of dengue diagnostic tests used for point-of-care testing (POCT) in ASEAN patients

Introduction: ASEAN countries are included in the 30 most highly dengue endemic countries in the world. Evaluation of the accuracy of dengue diagnostic tests is essential for clinical management, surveillance, control activities and vaccine development. Aim of this study is to review the accuracy of...

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Main Authors:	Tin, Myo Han, Swe, Swe Latt, Iskandar, Firzada Osman, D.M, Thuraiappah, Aung, Gyi, Mohd Aznan, Md Aris, Abdullah, Fa’iza, Tin, Tin Aye
Format:	Article
Language:	English
Published:	Malaysian Medical Associations 2015
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/50405/ http://irep.iium.edu.my/50405/ http://irep.iium.edu.my/50405/1/Asia-Pacific-Conference-on-public-health.pdf

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spelling	iium-504052020-03-03T07:56:26Z http://irep.iium.edu.my/50405/ A meta-analysis on the accuracy of dengue diagnostic tests used for point-of-care testing (POCT) in ASEAN patients Tin, Myo Han Swe, Swe Latt Iskandar, Firzada Osman D.M, Thuraiappah Aung, Gyi Mohd Aznan, Md Aris Abdullah, Fa’iza Tin, Tin Aye R Medicine (General) Introduction: ASEAN countries are included in the 30 most highly dengue endemic countries in the world. Evaluation of the accuracy of dengue diagnostic tests is essential for clinical management, surveillance, control activities and vaccine development. Aim of this study is to review the accuracy of diagnosis tests used for POCT for dengue infection. Methods: The accuracy results of 31 dengue diagnosis tests in 5308 ASEAN patients except Brunei were extracted from 14 articles published within 2007 and 2014. Rapid diagnosis tests (RDT) and WHO-Clinical criteria were considered for POCT. ELISA tests with/without WHO-Clinical criteria were included in meta-analysis. Pooled sensitivity (SN) and specificity (SP) were computed. Egger-bias was analysed for publication bias. Results: Pooled (range) SN of NS1(RDT) , IgM/IgG(RDT) , NS1+IgM/IgG (RDT) and WHO-Clinical criteria were 65% (44-79), 14% (3-50) ,80% (69-86) and 93% (80-97) while SP (range) of those tests were 99% (96-100), 97% (93-99), 96% (84-98) and 34% (20-57 )respectively. Pooled (range) of SN and SP of NS1 (ELISA) were 64% (45-82) and 99% (93-100. SN /SP (95% CI) of IgM/IgG (ELISA) were 50% (40-60) / 100% (96-100) and those of NS1+IgM/IgG (ELISA) were 94% (89-97)/92 % (81-97) and those of NS1+IgM/IgG (ELISA) with WHO -Clinical criteria were 91% (86-95)/ 94 % (84-98) respectively. Egger-bias was significant (p<0.0001). Discussion and conclusion: Both RDT and ELISA tests have high SP to rule in dengue diagnosis. Wide range of SN value (WHO-Clinical Criteria vs IgM/IgG RDT) highlighted to improve SN of the tests for ruling out. Added value of dengue epidemic information in the accuracy of the tests should be verified. A multi-centred study with a standardized protocol should be conducted for diagnostic test accuracy variation for POCT among ASEAN patients. Malaysian Medical Associations 2015-09-07 Article PeerReviewed application/pdf en http://irep.iium.edu.my/50405/1/Asia-Pacific-Conference-on-public-health.pdf Tin, Myo Han and Swe, Swe Latt and Iskandar, Firzada Osman and D.M, Thuraiappah and Aung, Gyi and Mohd Aznan, Md Aris and Abdullah, Fa’iza and Tin, Tin Aye (2015) A meta-analysis on the accuracy of dengue diagnostic tests used for point-of-care testing (POCT) in ASEAN patients. Medical Journal of Malaysia, 70 (1). p. 37. ISSN 0300-5283 http://www.e-mjm.org/2015/v70s1/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Tin, Myo Han Swe, Swe Latt Iskandar, Firzada Osman D.M, Thuraiappah Aung, Gyi Mohd Aznan, Md Aris Abdullah, Fa’iza Tin, Tin Aye A meta-analysis on the accuracy of dengue diagnostic tests used for point-of-care testing (POCT) in ASEAN patients
description	Introduction: ASEAN countries are included in the 30 most highly dengue endemic countries in the world. Evaluation of the accuracy of dengue diagnostic tests is essential for clinical management, surveillance, control activities and vaccine development. Aim of this study is to review the accuracy of diagnosis tests used for POCT for dengue infection. Methods: The accuracy results of 31 dengue diagnosis tests in 5308 ASEAN patients except Brunei were extracted from 14 articles published within 2007 and 2014. Rapid diagnosis tests (RDT) and WHO-Clinical criteria were considered for POCT. ELISA tests with/without WHO-Clinical criteria were included in meta-analysis. Pooled sensitivity (SN) and specificity (SP) were computed. Egger-bias was analysed for publication bias. Results: Pooled (range) SN of NS1(RDT) , IgM/IgG(RDT) , NS1+IgM/IgG (RDT) and WHO-Clinical criteria were 65% (44-79), 14% (3-50) ,80% (69-86) and 93% (80-97) while SP (range) of those tests were 99% (96-100), 97% (93-99), 96% (84-98) and 34% (20-57 )respectively. Pooled (range) of SN and SP of NS1 (ELISA) were 64% (45-82) and 99% (93-100. SN /SP (95% CI) of IgM/IgG (ELISA) were 50% (40-60) / 100% (96-100) and those of NS1+IgM/IgG (ELISA) were 94% (89-97)/92 % (81-97) and those of NS1+IgM/IgG (ELISA) with WHO -Clinical criteria were 91% (86-95)/ 94 % (84-98) respectively. Egger-bias was significant (p<0.0001). Discussion and conclusion: Both RDT and ELISA tests have high SP to rule in dengue diagnosis. Wide range of SN value (WHO-Clinical Criteria vs IgM/IgG RDT) highlighted to improve SN of the tests for ruling out. Added value of dengue epidemic information in the accuracy of the tests should be verified. A multi-centred study with a standardized protocol should be conducted for diagnostic test accuracy variation for POCT among ASEAN patients.
format	Article
author	Tin, Myo Han Swe, Swe Latt Iskandar, Firzada Osman D.M, Thuraiappah Aung, Gyi Mohd Aznan, Md Aris Abdullah, Fa’iza Tin, Tin Aye
author_facet	Tin, Myo Han Swe, Swe Latt Iskandar, Firzada Osman D.M, Thuraiappah Aung, Gyi Mohd Aznan, Md Aris Abdullah, Fa’iza Tin, Tin Aye
author_sort	Tin, Myo Han
title	A meta-analysis on the accuracy of dengue diagnostic tests used for point-of-care testing (POCT) in ASEAN patients
title_short	A meta-analysis on the accuracy of dengue diagnostic tests used for point-of-care testing (POCT) in ASEAN patients
title_full	A meta-analysis on the accuracy of dengue diagnostic tests used for point-of-care testing (POCT) in ASEAN patients
title_fullStr	A meta-analysis on the accuracy of dengue diagnostic tests used for point-of-care testing (POCT) in ASEAN patients
title_full_unstemmed	A meta-analysis on the accuracy of dengue diagnostic tests used for point-of-care testing (POCT) in ASEAN patients
title_sort	meta-analysis on the accuracy of dengue diagnostic tests used for point-of-care testing (poct) in asean patients
publisher	Malaysian Medical Associations
publishDate	2015
url	http://irep.iium.edu.my/50405/ http://irep.iium.edu.my/50405/ http://irep.iium.edu.my/50405/1/Asia-Pacific-Conference-on-public-health.pdf
first_indexed	2023-09-18T21:11:15Z
last_indexed	2023-09-18T21:11:15Z
_version_	1777411267068166144

A meta-analysis on the accuracy of dengue diagnostic tests used for point-of-care testing (POCT) in ASEAN patients

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