Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study

The objective of this study was to examine the effect of Eurycoma longifolia (EL) extract on intima media thickness (IMT) of aorta in Sprague Dawley (SD) rats fed with high-fat diet. Twenty healthy male SD rats were divided into 4 groups of 5 animals each and treated for 12 weeks as follows: Group N...

Full description

Bibliographic Details
Main Authors:	Al-Jaufi, Fakhria, Al-Ani, Imad M, Saxena, Anil Kumar, Talib, Norlelawati A., H. Mokhtar, Rafidah, Ku-Zaifah, Norsidah
Format:	Article
Language:	English English
Published:	The Spanish Society of Anatomy 2016
Subjects:	R Medicine (General) RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/50698/ http://irep.iium.edu.my/50698/ http://irep.iium.edu.my/50698/1/Article_2016.pdf http://irep.iium.edu.my/50698/4/50698_Assessment%20of%20anti-atherosclerotic%20effect_Scopus.pdf

id	iium-50698
recordtype	eprints
spelling	iium-506982017-04-04T02:16:56Z http://irep.iium.edu.my/50698/ Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study Al-Jaufi, Fakhria Al-Ani, Imad M Saxena, Anil Kumar Talib, Norlelawati A. H. Mokhtar, Rafidah Ku-Zaifah, Norsidah R Medicine (General) RM Therapeutics. Pharmacology The objective of this study was to examine the effect of Eurycoma longifolia (EL) extract on intima media thickness (IMT) of aorta in Sprague Dawley (SD) rats fed with high-fat diet. Twenty healthy male SD rats were divided into 4 groups of 5 animals each and treated for 12 weeks as follows: Group ND was given only normal diet, Group NDEL was given normal diet and EL, Group HFD was given only high fat diet, Group HFDEL was given HFD and EL extracts. The aortic thicknesses of the intima media were photographed and measured with Dino-Capture® 2.0.In this study, the HFD produced obvious atherosclerotic plaque; treatment with aqueous extract of EL has reduced the size and formation of atherosclerotic plaque. The aortic IMT was more significantly increased in the HFD group than that of ND (p < 0.05); on the other hand, the aortic IMT was more significantly reduced in HFDEL group than that of HFD group (p < 0.05). It is concluded that the aqueous extract of EL significantly attenuated the formation of atherosclerotic plaques in the aorta of rats and preserved the vascular structure. The Spanish Society of Anatomy 2016-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/50698/1/Article_2016.pdf application/pdf en http://irep.iium.edu.my/50698/4/50698_Assessment%20of%20anti-atherosclerotic%20effect_Scopus.pdf Al-Jaufi, Fakhria and Al-Ani, Imad M and Saxena, Anil Kumar and Talib, Norlelawati A. and H. Mokhtar, Rafidah and Ku-Zaifah, Norsidah (2016) Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study. European Journal of Anatomy, 20 (2). pp. 131-136. ISSN 1136-4890 E-ISSN 2340-311X http://eurjanat.com/data/pdf/eja.150350ia.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General) RM Therapeutics. Pharmacology
spellingShingle	R Medicine (General) RM Therapeutics. Pharmacology Al-Jaufi, Fakhria Al-Ani, Imad M Saxena, Anil Kumar Talib, Norlelawati A. H. Mokhtar, Rafidah Ku-Zaifah, Norsidah Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study
description	The objective of this study was to examine the effect of Eurycoma longifolia (EL) extract on intima media thickness (IMT) of aorta in Sprague Dawley (SD) rats fed with high-fat diet. Twenty healthy male SD rats were divided into 4 groups of 5 animals each and treated for 12 weeks as follows: Group ND was given only normal diet, Group NDEL was given normal diet and EL, Group HFD was given only high fat diet, Group HFDEL was given HFD and EL extracts. The aortic thicknesses of the intima media were photographed and measured with Dino-Capture® 2.0.In this study, the HFD produced obvious atherosclerotic plaque; treatment with aqueous extract of EL has reduced the size and formation of atherosclerotic plaque. The aortic IMT was more significantly increased in the HFD group than that of ND (p < 0.05); on the other hand, the aortic IMT was more significantly reduced in HFDEL group than that of HFD group (p < 0.05). It is concluded that the aqueous extract of EL significantly attenuated the formation of atherosclerotic plaques in the aorta of rats and preserved the vascular structure.
format	Article
author	Al-Jaufi, Fakhria Al-Ani, Imad M Saxena, Anil Kumar Talib, Norlelawati A. H. Mokhtar, Rafidah Ku-Zaifah, Norsidah
author_facet	Al-Jaufi, Fakhria Al-Ani, Imad M Saxena, Anil Kumar Talib, Norlelawati A. H. Mokhtar, Rafidah Ku-Zaifah, Norsidah
author_sort	Al-Jaufi, Fakhria
title	Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study
title_short	Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study
title_full	Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study
title_fullStr	Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study
title_full_unstemmed	Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study
title_sort	assessment of anti-atherosclerotic effect of eurycoma longifolia extract on high-fat diet model in rats. i: histological study
publisher	The Spanish Society of Anatomy
publishDate	2016
url	http://irep.iium.edu.my/50698/ http://irep.iium.edu.my/50698/ http://irep.iium.edu.my/50698/1/Article_2016.pdf http://irep.iium.edu.my/50698/4/50698_Assessment%20of%20anti-atherosclerotic%20effect_Scopus.pdf
first_indexed	2023-09-18T21:11:41Z
last_indexed	2023-09-18T21:11:41Z
_version_	1777411294869061632

Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study

Similar Items