Distribution pattern of hepatitis c virus in eastern peninsular malaysia for the past decade
Introduction: Analysis of the Hepatitis C Virus’ (HCV) genotypic spread in a particular area has a crucial impact on public health. Genotyping is essential before initiating treatment. Methodology: This is a hospital-based cohort of 133 chronic hepatitis C patients, collected prospectively among su...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Faculty of Medicine, International Islamic University Malaysia
2015
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/50719/ http://irep.iium.edu.my/50719/ http://irep.iium.edu.my/50719/1/50719_-_Distribution_pattern_of_hepatitis_c_virus_in_eastern_peninsular_malaysia_for_the_past_decade.pdf |
| Summary: | Introduction: Analysis of the Hepatitis C Virus’ (HCV) genotypic spread in a particular area has a crucial impact on public health. Genotyping is essential before initiating treatment.
Methodology: This is a hospital-based cohort of 133 chronic hepatitis C patients, collected prospectively among subjects attending Hospital Tengku Ampuan Afzan, Kuantan, within an area of eastern Peninsular Malaysia. We assessed the rate and distribution of HCV genotypes during two consecutive periods, from 2005 to 2006 and from 2013 to 2014, according to age, gender, race and risk factors.
Results: There were more male, Malay ethnic and IDU patients seen in the latter cohort. Genotype 3 was the dominant genotype followed by genotype 1, 4 and 6. Statistical evaluation of the demographics of HCV patients stratified by genotypes did not reveal any significant difference between the two periods. There was no association between the risk factors analyzed and the acquisition of different HCV genotypes. However, there was significant difference between males and patients receiving treatment in the second cohort (p<0.005).
Conclusion: The genotype distribution remains similar although there was a trend towards having slightly more
genotype 3 in the latter years. The proportions of male patients and patients receiving treatment in the latter period were
significantly higher. |
|---|