Incrassamarin A–D: Four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities

Four new 4-substituted coumarins, incrassamarin A (1), B (2), C (3) and D (4) with (7S,8S)-7,8-dihydro-5- hydroxy-7,8-dimethyl-4-propyl-2H,6H-benzo[1,2-b;5,4-b’]dipyran-2,6-dione (5), friedelin, carpachromene, amentoflavone, epiafzelechin and L-quercitrin were isolated from the barks and leaves of...

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Main Authors:	Aminudin, Nurul Iman, Ahmad, Farediah, Bakhtiar, M. Taher, Mohamed Zulkifli, Razauden
Format:	Article
Language:	English English
Published:	Elsevier 2016
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/50956/ http://irep.iium.edu.my/50956/ http://irep.iium.edu.my/50956/ http://irep.iium.edu.my/50956/2/Incrassamarin_A%E2%80%93D_Four_new_4-substituted_coumarins__from.pdf http://irep.iium.edu.my/50956/7/50956_Incrassamarin%20A%E2%80%93D_WoS.pdf

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recordtype	eprints
spelling	iium-509562017-10-04T01:35:43Z http://irep.iium.edu.my/50956/ Incrassamarin A–D: Four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Razauden RS Pharmacy and materia medica Four new 4-substituted coumarins, incrassamarin A (1), B (2), C (3) and D (4) with (7S,8S)-7,8-dihydro-5- hydroxy-7,8-dimethyl-4-propyl-2H,6H-benzo[1,2-b;5,4-b’]dipyran-2,6-dione (5), friedelin, carpachromene, amentoflavone, epiafzelechin and L-quercitrin were isolated from the barks and leaves of Calophyllum incrassatum (Guttiferae). The compounds were isolated and purified by size-exclusion recycling HPLC and column chromatographic techniques. The structures of the compounds were determined by spectroscopic means. The compounds were tested for their cytotoxic activity towards MCF-7 and A-549 cell lines and a-glucosidase enzymatic inhibitory activity. Compound (1) displayed cytotoxic activity against A-549 cell lines with IC50 87.71mg/mL and showed inhibition towards a-glucosidase enzymatic activity with IC50 93.25mM. This is the first report on the isolation of phytochemicals from the barks and leaves of C. incrassatum and their bioactivities. Elsevier 2016-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/50956/2/Incrassamarin_A%E2%80%93D_Four_new_4-substituted_coumarins__from.pdf application/pdf en http://irep.iium.edu.my/50956/7/50956_Incrassamarin%20A%E2%80%93D_WoS.pdf Aminudin, Nurul Iman and Ahmad, Farediah and Bakhtiar, M. Taher and Mohamed Zulkifli, Razauden (2016) Incrassamarin A–D: Four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities. Phytochemistry Letters, 16. pp. 287-293. ISSN 1874-3900 http://www.sciencedirect.com/science/article/pii/S1874390016300714 10.1016/j.phytol.2016.05.008
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Razauden Incrassamarin A–D: Four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities
description	Four new 4-substituted coumarins, incrassamarin A (1), B (2), C (3) and D (4) with (7S,8S)-7,8-dihydro-5- hydroxy-7,8-dimethyl-4-propyl-2H,6H-benzo[1,2-b;5,4-b’]dipyran-2,6-dione (5), friedelin, carpachromene, amentoflavone, epiafzelechin and L-quercitrin were isolated from the barks and leaves of Calophyllum incrassatum (Guttiferae). The compounds were isolated and purified by size-exclusion recycling HPLC and column chromatographic techniques. The structures of the compounds were determined by spectroscopic means. The compounds were tested for their cytotoxic activity towards MCF-7 and A-549 cell lines and a-glucosidase enzymatic inhibitory activity. Compound (1) displayed cytotoxic activity against A-549 cell lines with IC50 87.71mg/mL and showed inhibition towards a-glucosidase enzymatic activity with IC50 93.25mM. This is the first report on the isolation of phytochemicals from the barks and leaves of C. incrassatum and their bioactivities.
format	Article
author	Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Razauden
author_facet	Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Razauden
author_sort	Aminudin, Nurul Iman
title	Incrassamarin A–D: Four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities
title_short	Incrassamarin A–D: Four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities
title_full	Incrassamarin A–D: Four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities
title_fullStr	Incrassamarin A–D: Four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities
title_full_unstemmed	Incrassamarin A–D: Four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities
title_sort	incrassamarin a–d: four new 4-substituted coumarins from calophyllum incrassatum and their biological activities
publisher	Elsevier
publishDate	2016
url	http://irep.iium.edu.my/50956/ http://irep.iium.edu.my/50956/ http://irep.iium.edu.my/50956/ http://irep.iium.edu.my/50956/2/Incrassamarin_A%E2%80%93D_Four_new_4-substituted_coumarins__from.pdf http://irep.iium.edu.my/50956/7/50956_Incrassamarin%20A%E2%80%93D_WoS.pdf
first_indexed	2023-09-18T21:12:07Z
last_indexed	2023-09-18T21:12:07Z
_version_	1777411322300858368

Incrassamarin A–D: Four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities

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