Antifungal activity of Eurycoma longifolia jack (Tongkat Ali) root extract
Eurycoma longifolia jack (Tongkat Ali) has been known to possess many important biological properties and its uses are gradually expanding . To test the presence of antifungal activity of the ethanolic Eurycoma longifolia Jack (E.L) root extract. E.L. roots were extracted using ethanol . Two type...
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Ectodermal Dysplasia Group-Turkey
2016
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iium-509812016-12-20T04:10:42Z http://irep.iium.edu.my/50981/ Antifungal activity of Eurycoma longifolia jack (Tongkat Ali) root extract Faisal, Ghasak Ghazi Zakaria, Siti Mastura Najmuldeen, Ghazi Faisal Al-Ani, Imad Matloub Dally R Medicine (General) RB Pathology Eurycoma longifolia jack (Tongkat Ali) has been known to possess many important biological properties and its uses are gradually expanding . To test the presence of antifungal activity of the ethanolic Eurycoma longifolia Jack (E.L) root extract. E.L. roots were extracted using ethanol . Two types of fungal strains were used; Candida albicans and Aspergillus fumigatus. Disc diffusion assay and Minimum inhibitory concentration (MIC) tests were used to determine the antifungal activity. The extract was prepared into three concentrations of 50, 100 and 150 mg/ml, Nystatin was used as positive control. The ethanolic extract of E. longifolia Jack root showed positive antifungal activity against C.albicans and A.fumigatus. The antifungal activity, measured through the zone of growth inhibition on the agar disc diffusion assay, against A.fumigatus was recorded to be 3.78±0.63, 6.11±1.45, 9.89±0.74mm, while for C.albicans was 4.44±0.5, 6.56±0.50, 8.44±0.90 mm for the extract concentrations of 50, 100 and 150 mg/ml respectively. The results of MIC showed the inhibition of visible growth of A.fumigatus and C.albicans at the minimum concentration of 12.5 and 25 mg/ml respectively. E.L root extract possesses potent antifungal properties and has the potential to be used as a medicinal product. Ectodermal Dysplasia Group-Turkey 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/50981/1/Antifungal_activity_of_eurycoma_longifolia_root_extract.pdf application/pdf en http://irep.iium.edu.my/50981/4/50981_Antifungal%20activity_scopus.pdf Faisal, Ghasak Ghazi and Zakaria, Siti Mastura and Najmuldeen, Ghazi Faisal and Al-Ani, Imad Matloub Dally (2016) Antifungal activity of Eurycoma longifolia jack (Tongkat Ali) root extract. Journal of International Dental and Medical Research, 9 (1). pp. 70-74. ISSN 1309-100X http://www.ektodermaldisplazi.com/journal/Journal2016/Vol9_No1/13_D16_297_Ghasak_Ghazi_Faisal.pdf |
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Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
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| collection |
Online Access |
| language |
English English |
| topic |
R Medicine (General) RB Pathology |
| spellingShingle |
R Medicine (General) RB Pathology Faisal, Ghasak Ghazi Zakaria, Siti Mastura Najmuldeen, Ghazi Faisal Al-Ani, Imad Matloub Dally Antifungal activity of Eurycoma longifolia jack (Tongkat Ali) root extract |
| description |
Eurycoma longifolia jack (Tongkat Ali) has been known to possess many important biological
properties and its uses are gradually expanding . To test the presence of antifungal activity of the
ethanolic Eurycoma longifolia Jack (E.L) root extract. E.L. roots were extracted using ethanol . Two
types of fungal strains were used; Candida albicans and Aspergillus fumigatus. Disc diffusion assay
and Minimum inhibitory concentration (MIC) tests were used to determine the antifungal activity.
The extract was prepared into three concentrations of 50, 100 and 150 mg/ml, Nystatin was used
as positive control. The ethanolic extract of E. longifolia Jack root showed positive antifungal activity
against C.albicans and A.fumigatus. The antifungal activity, measured through the zone of growth
inhibition on the agar disc diffusion assay, against A.fumigatus was recorded to be 3.78±0.63,
6.11±1.45, 9.89±0.74mm, while for C.albicans was 4.44±0.5, 6.56±0.50, 8.44±0.90 mm for the
extract concentrations of 50, 100 and 150 mg/ml respectively. The results of MIC showed the
inhibition of visible growth of A.fumigatus and C.albicans at the minimum concentration of 12.5
and 25 mg/ml respectively. E.L root extract possesses potent antifungal properties and has the
potential to be used as a medicinal product. |
| format |
Article |
| author |
Faisal, Ghasak Ghazi Zakaria, Siti Mastura Najmuldeen, Ghazi Faisal Al-Ani, Imad Matloub Dally |
| author_facet |
Faisal, Ghasak Ghazi Zakaria, Siti Mastura Najmuldeen, Ghazi Faisal Al-Ani, Imad Matloub Dally |
| author_sort |
Faisal, Ghasak Ghazi |
| title |
Antifungal activity of Eurycoma longifolia jack (Tongkat Ali) root extract |
| title_short |
Antifungal activity of Eurycoma longifolia jack (Tongkat Ali) root extract |
| title_full |
Antifungal activity of Eurycoma longifolia jack (Tongkat Ali) root extract |
| title_fullStr |
Antifungal activity of Eurycoma longifolia jack (Tongkat Ali) root extract |
| title_full_unstemmed |
Antifungal activity of Eurycoma longifolia jack (Tongkat Ali) root extract |
| title_sort |
antifungal activity of eurycoma longifolia jack (tongkat ali) root extract |
| publisher |
Ectodermal Dysplasia Group-Turkey |
| publishDate |
2016 |
| url |
http://irep.iium.edu.my/50981/ http://irep.iium.edu.my/50981/ http://irep.iium.edu.my/50981/1/Antifungal_activity_of_eurycoma_longifolia_root_extract.pdf http://irep.iium.edu.my/50981/4/50981_Antifungal%20activity_scopus.pdf |
| first_indexed |
2023-09-18T21:12:09Z |
| last_indexed |
2023-09-18T21:12:09Z |
| _version_ |
1777411323617869824 |