Advanced characterization of ethanolic nano lipid vesicles loaded with raloxifene HCl for transdermal drug delivery

Ethanolic nano lipid vesicles are also known as ethosomes. They are novel elastic vesicles used as non-invasive drug delivery carriers for transdermal applications. This ethosomal system is composed of phospholipid, ethanol and water. The purpose of this research was to develop and characterize an e...

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Main Authors:	Mahmood, Syed, Bakhtiar, M. Taher, Chatterjee, Bappaditya, Mandal, Uttam Kumar
Format:	Conference or Workshop Item
Language:	English English
Published:	Faculty of Pharmaceutical Science, Prince of Songkla University, Thailand 2016
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/51058/ http://irep.iium.edu.my/51058/ http://irep.iium.edu.my/51058/1/51058_poster.pdf http://irep.iium.edu.my/51058/2/51058_abstract.pdf

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recordtype	eprints
spelling	iium-510582017-10-20T01:09:40Z http://irep.iium.edu.my/51058/ Advanced characterization of ethanolic nano lipid vesicles loaded with raloxifene HCl for transdermal drug delivery Mahmood, Syed Bakhtiar, M. Taher Chatterjee, Bappaditya Mandal, Uttam Kumar RS Pharmacy and materia medica Ethanolic nano lipid vesicles are also known as ethosomes. They are novel elastic vesicles used as non-invasive drug delivery carriers for transdermal applications. This ethosomal system is composed of phospholipid, ethanol and water. The purpose of this research was to develop and characterize an ethosomal formulation of raloxifene HCl to deliver the drug into systemic circulation through the transdermal route. This was aimed to minimize the dose of the drug and achieve the maximum bioavailability in order to reduce the side effects associated with its repeated dose regimen. The drug loaded ethosomal formulation was prepared by the rotary evaporation method. The size, zeta potential and polydispersity index (PDI) of the formulation were measured. The drug entrapment efficiency of the vesicles was determined by an ultracentrifugation method. Ex vivo skin permeation study was conducted to measure transdermal flux (J) by Franz diffusion cell with rat skin as a barrier membrane. The advanced structural and skin penetration characterizations were carried out by force emission scanning electron microscope (FESEM), transmission electron microscope (TEM). Confocal laser scanning microscopy (CLSM) study was performed to view the permeated nanovesicles in the skin layers. The size, charge, PDI and ex vivo transdermal flux (J) of the developed formulation showed favorable values required for the stability and efficient transdermal drug delivery. FESM and TEM study confirmed nano size and structural morphology of the vesicles. CLSM microscopic studies proved an enhanced drug penetration into the different skin layers compared to the conventional liposomes and drug solution in ethanolic phosphate buffer. The developed nano lipid vesicles (ethosomes) might be promising carriers for transdermal drug delivery of raloxifene HCl. Faculty of Pharmaceutical Science, Prince of Songkla University, Thailand 2016-06-01 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/51058/1/51058_poster.pdf application/pdf en http://irep.iium.edu.my/51058/2/51058_abstract.pdf Mahmood, Syed and Bakhtiar, M. Taher and Chatterjee, Bappaditya and Mandal, Uttam Kumar (2016) Advanced characterization of ethanolic nano lipid vesicles loaded with raloxifene HCl for transdermal drug delivery. In: The 4th Current Drug Development International Conference (CDD 2016), 1st-3rd June 2016, Thailand. http://cdd2016.pharmacy.psu.ac.th/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Mahmood, Syed Bakhtiar, M. Taher Chatterjee, Bappaditya Mandal, Uttam Kumar Advanced characterization of ethanolic nano lipid vesicles loaded with raloxifene HCl for transdermal drug delivery
description	Ethanolic nano lipid vesicles are also known as ethosomes. They are novel elastic vesicles used as non-invasive drug delivery carriers for transdermal applications. This ethosomal system is composed of phospholipid, ethanol and water. The purpose of this research was to develop and characterize an ethosomal formulation of raloxifene HCl to deliver the drug into systemic circulation through the transdermal route. This was aimed to minimize the dose of the drug and achieve the maximum bioavailability in order to reduce the side effects associated with its repeated dose regimen. The drug loaded ethosomal formulation was prepared by the rotary evaporation method. The size, zeta potential and polydispersity index (PDI) of the formulation were measured. The drug entrapment efficiency of the vesicles was determined by an ultracentrifugation method. Ex vivo skin permeation study was conducted to measure transdermal flux (J) by Franz diffusion cell with rat skin as a barrier membrane. The advanced structural and skin penetration characterizations were carried out by force emission scanning electron microscope (FESEM), transmission electron microscope (TEM). Confocal laser scanning microscopy (CLSM) study was performed to view the permeated nanovesicles in the skin layers. The size, charge, PDI and ex vivo transdermal flux (J) of the developed formulation showed favorable values required for the stability and efficient transdermal drug delivery. FESM and TEM study confirmed nano size and structural morphology of the vesicles. CLSM microscopic studies proved an enhanced drug penetration into the different skin layers compared to the conventional liposomes and drug solution in ethanolic phosphate buffer. The developed nano lipid vesicles (ethosomes) might be promising carriers for transdermal drug delivery of raloxifene HCl.
format	Conference or Workshop Item
author	Mahmood, Syed Bakhtiar, M. Taher Chatterjee, Bappaditya Mandal, Uttam Kumar
author_facet	Mahmood, Syed Bakhtiar, M. Taher Chatterjee, Bappaditya Mandal, Uttam Kumar
author_sort	Mahmood, Syed
title	Advanced characterization of ethanolic nano lipid vesicles loaded with raloxifene HCl for transdermal drug delivery
title_short	Advanced characterization of ethanolic nano lipid vesicles loaded with raloxifene HCl for transdermal drug delivery
title_full	Advanced characterization of ethanolic nano lipid vesicles loaded with raloxifene HCl for transdermal drug delivery
title_fullStr	Advanced characterization of ethanolic nano lipid vesicles loaded with raloxifene HCl for transdermal drug delivery
title_full_unstemmed	Advanced characterization of ethanolic nano lipid vesicles loaded with raloxifene HCl for transdermal drug delivery
title_sort	advanced characterization of ethanolic nano lipid vesicles loaded with raloxifene hcl for transdermal drug delivery
publisher	Faculty of Pharmaceutical Science, Prince of Songkla University, Thailand
publishDate	2016
url	http://irep.iium.edu.my/51058/ http://irep.iium.edu.my/51058/ http://irep.iium.edu.my/51058/1/51058_poster.pdf http://irep.iium.edu.my/51058/2/51058_abstract.pdf
first_indexed	2023-09-18T21:12:13Z
last_indexed	2023-09-18T21:12:13Z
_version_	1777411328780009472

Advanced characterization of ethanolic nano lipid vesicles loaded with raloxifene HCl for transdermal drug delivery

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