Gastro-retentive drug delivery systems and their in vivo success: A recent update

Gastro-retentive drug delivery system (GRDDS) has gained immense popularity in the field of oral drug delivery recently. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated w...

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Main Authors:	Mandal, Uttam Kumar, Chatterjee, Bappaditya, Senjoti, Faria Gias
Format:	Article
Language:	English
Published:	Elsevier 2016
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/51074/ http://irep.iium.edu.my/51074/ http://irep.iium.edu.my/51074/ http://irep.iium.edu.my/51074/1/Asian_Journal_of_Pharmaceutical_Sciences.pdf

id	iium-51074
recordtype	eprints
spelling	iium-510742016-07-19T02:30:35Z http://irep.iium.edu.my/51074/ Gastro-retentive drug delivery systems and their in vivo success: A recent update Mandal, Uttam Kumar Chatterjee, Bappaditya Senjoti, Faria Gias RS Pharmacy and materia medica Gastro-retentive drug delivery system (GRDDS) has gained immense popularity in the field of oral drug delivery recently. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. Different innovative approaches like magnetic field assisted gastro-retention, plug type swelling system, muco-adhesion technique, floating system with or without effervescence are being applied to fabricate GRDDS. Apart from in vitro characterization, successful GRDDS development demands well designed in vivo study to establish enhanced gastro-retention and prolonged drug release. Gama scintigraphy and MRI are popular techniques to evaluate in vivo gastric residence time. However, checking of their overall in-vivo efficacy still remains a major challenge for this kind of dosage form, especially in small animals like mice or rat. Reported in vivo studies with beagle dogs, rabbits, and human subjects are only a handful in spite of a large number of encouraging in vitro results. In spite of the many advantages, high subject variations in gastrointestinal physiological condition, effect of food, variable rate of gastric emptying time are the challenges which limit the number of available GRDDS in the market. This review article highlights the in vivo works of GRDDS carried out in the recent past, including their limitations and challenges need to overcome in the near future. Elsevier 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/51074/1/Asian_Journal_of_Pharmaceutical_Sciences.pdf Mandal, Uttam Kumar and Chatterjee, Bappaditya and Senjoti, Faria Gias (2016) Gastro-retentive drug delivery systems and their in vivo success: A recent update. Asian Journal of Pharmaceutical Sciences. pp. 1-25. ISSN 1818-0876 (In Press) http://www.sciencedirect.com/science/article/pii/S1818087616300320 10.1016/j.ajps.2016.04.007
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Mandal, Uttam Kumar Chatterjee, Bappaditya Senjoti, Faria Gias Gastro-retentive drug delivery systems and their in vivo success: A recent update
description	Gastro-retentive drug delivery system (GRDDS) has gained immense popularity in the field of oral drug delivery recently. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. Different innovative approaches like magnetic field assisted gastro-retention, plug type swelling system, muco-adhesion technique, floating system with or without effervescence are being applied to fabricate GRDDS. Apart from in vitro characterization, successful GRDDS development demands well designed in vivo study to establish enhanced gastro-retention and prolonged drug release. Gama scintigraphy and MRI are popular techniques to evaluate in vivo gastric residence time. However, checking of their overall in-vivo efficacy still remains a major challenge for this kind of dosage form, especially in small animals like mice or rat. Reported in vivo studies with beagle dogs, rabbits, and human subjects are only a handful in spite of a large number of encouraging in vitro results. In spite of the many advantages, high subject variations in gastrointestinal physiological condition, effect of food, variable rate of gastric emptying time are the challenges which limit the number of available GRDDS in the market. This review article highlights the in vivo works of GRDDS carried out in the recent past, including their limitations and challenges need to overcome in the near future.
format	Article
author	Mandal, Uttam Kumar Chatterjee, Bappaditya Senjoti, Faria Gias
author_facet	Mandal, Uttam Kumar Chatterjee, Bappaditya Senjoti, Faria Gias
author_sort	Mandal, Uttam Kumar
title	Gastro-retentive drug delivery systems and their in vivo success: A recent update
title_short	Gastro-retentive drug delivery systems and their in vivo success: A recent update
title_full	Gastro-retentive drug delivery systems and their in vivo success: A recent update
title_fullStr	Gastro-retentive drug delivery systems and their in vivo success: A recent update
title_full_unstemmed	Gastro-retentive drug delivery systems and their in vivo success: A recent update
title_sort	gastro-retentive drug delivery systems and their in vivo success: a recent update
publisher	Elsevier
publishDate	2016
url	http://irep.iium.edu.my/51074/ http://irep.iium.edu.my/51074/ http://irep.iium.edu.my/51074/ http://irep.iium.edu.my/51074/1/Asian_Journal_of_Pharmaceutical_Sciences.pdf
first_indexed	2023-09-18T21:12:15Z
last_indexed	2023-09-18T21:12:15Z
_version_	1777411330795372544

Gastro-retentive drug delivery systems and their in vivo success: A recent update

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