Aquilaria spp. (agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology

Ethnopharmacological relevance: Aquilaria spp. (agarwood) has been a part of Ayurvedic and Traditional Chinese Medicine for centuries. Agarwood has also been used as a traditional medicine in Southeast Asian countries, Bangladesh and Tibet. Its common uses include the treatment of joint pain, in-...

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Main Authors:	Hashim, Yumi Zuhanis Has-Yun, Kerr, Philip G., Abbas, Phirdaous, Mohd Salleh, Hamzah
Format:	Article
Language:	English English
Published:	2016
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/51380/ http://irep.iium.edu.my/51380/ http://irep.iium.edu.my/51380/ http://irep.iium.edu.my/51380/1/Paper_-Hashim_et_al_2016_%28JEP%29.pdf http://irep.iium.edu.my/51380/4/51380_Aquilaria%20spp.%20%28agarwood%29%20as%20source%20of%20health%20beneficial%20compounds_Scopus.pdf

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spelling	iium-513802017-04-03T08:12:09Z http://irep.iium.edu.my/51380/ Aquilaria spp. (agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology Hashim, Yumi Zuhanis Has-Yun Kerr, Philip G. Abbas, Phirdaous Mohd Salleh, Hamzah Q Science (General) Ethnopharmacological relevance: Aquilaria spp. (agarwood) has been a part of Ayurvedic and Traditional Chinese Medicine for centuries. Agarwood has also been used as a traditional medicine in Southeast Asian countries, Bangladesh and Tibet. Its common uses include the treatment of joint pain, in- flammatory-related ailments, and diarrhoea, as well as a stimulant, sedative and cardioprotective agent. In this paper, we aim to provide an overview of the phytochemistry, ethnomedicinal use, pharmacological activities and safety of plant materials from Aquilaria spp. as an evidence base to further appraise its potential use as a source of health beneficial compounds. Materials and methods: Literature abstracts and full text articles from journals, books, reports and electronic searches (Google Scholar, Elsevier, PubMed, Read Cube, Scopus, Springer, and Web of Science), as well as from other relevant websites, are surveyed, analysed and included in this review. Results: A literature survey of agarwood plant materials showed that they contain sesquiterpenes, 2(-2- phenylethyl)-4H-chromen-4-one derivatives, genkwanins, mangiferins, iriflophenones, cucurbitacins, terpenoids and phenolic acids. The crude extracts and some of the isolated compounds exhibit antiallergic, anti-inflammatory, anti-diabetic, anti-cancer, anti-oxidant, anti-ischemic, anti-microbial, hepatoprotective, laxative, and mosquitocidal properties and effects on the central nervous system. Agarwood plant materials are considered to be safe based on the doses tested. However, the toxicity and safety of the materials, including the smoke from agarwood incense burning, should be further investigated. Future research should be directed towards the bio-guided isolation of bioactive compounds with proper chemical characterisation and investigations of the underlying mechanisms towards drug discovery. Conclusions: The traditional medicinal use of agarwood plant materials has provided clues to their pharmacological properties. Indeed, agarwood contains a plethora of bioactive compounds that now elegantly support their use in traditional medicine. As wild agarwood trees are critically endangered and vulnerable, sustainable agricultural and forestry practices are necessary for the further development and utilization of agarwood as a source of health beneficial compounds. 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/51380/1/Paper_-Hashim_et_al_2016_%28JEP%29.pdf application/pdf en http://irep.iium.edu.my/51380/4/51380_Aquilaria%20spp.%20%28agarwood%29%20as%20source%20of%20health%20beneficial%20compounds_Scopus.pdf Hashim, Yumi Zuhanis Has-Yun and Kerr, Philip G. and Abbas, Phirdaous and Mohd Salleh, Hamzah (2016) Aquilaria spp. (agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology. Journal of Ethnopharmacology, 189. pp. 331-360. ISSN 0378-8741 http://ac.els-cdn.com/S0378874116304159/1-s2.0-S0378874116304159-main.pdf?_tid=9d326bb0-57c0-11e6-b712-00000aacb361&acdnat=1470039726_69346d0743a9e1d10dce54b889b8b4c5 doi:10.1016/j.jep.2016.06.055
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	Q Science (General)
spellingShingle	Q Science (General) Hashim, Yumi Zuhanis Has-Yun Kerr, Philip G. Abbas, Phirdaous Mohd Salleh, Hamzah Aquilaria spp. (agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology
description	Ethnopharmacological relevance: Aquilaria spp. (agarwood) has been a part of Ayurvedic and Traditional Chinese Medicine for centuries. Agarwood has also been used as a traditional medicine in Southeast Asian countries, Bangladesh and Tibet. Its common uses include the treatment of joint pain, in- flammatory-related ailments, and diarrhoea, as well as a stimulant, sedative and cardioprotective agent. In this paper, we aim to provide an overview of the phytochemistry, ethnomedicinal use, pharmacological activities and safety of plant materials from Aquilaria spp. as an evidence base to further appraise its potential use as a source of health beneficial compounds. Materials and methods: Literature abstracts and full text articles from journals, books, reports and electronic searches (Google Scholar, Elsevier, PubMed, Read Cube, Scopus, Springer, and Web of Science), as well as from other relevant websites, are surveyed, analysed and included in this review. Results: A literature survey of agarwood plant materials showed that they contain sesquiterpenes, 2(-2- phenylethyl)-4H-chromen-4-one derivatives, genkwanins, mangiferins, iriflophenones, cucurbitacins, terpenoids and phenolic acids. The crude extracts and some of the isolated compounds exhibit antiallergic, anti-inflammatory, anti-diabetic, anti-cancer, anti-oxidant, anti-ischemic, anti-microbial, hepatoprotective, laxative, and mosquitocidal properties and effects on the central nervous system. Agarwood plant materials are considered to be safe based on the doses tested. However, the toxicity and safety of the materials, including the smoke from agarwood incense burning, should be further investigated. Future research should be directed towards the bio-guided isolation of bioactive compounds with proper chemical characterisation and investigations of the underlying mechanisms towards drug discovery. Conclusions: The traditional medicinal use of agarwood plant materials has provided clues to their pharmacological properties. Indeed, agarwood contains a plethora of bioactive compounds that now elegantly support their use in traditional medicine. As wild agarwood trees are critically endangered and vulnerable, sustainable agricultural and forestry practices are necessary for the further development and utilization of agarwood as a source of health beneficial compounds.
format	Article
author	Hashim, Yumi Zuhanis Has-Yun Kerr, Philip G. Abbas, Phirdaous Mohd Salleh, Hamzah
author_facet	Hashim, Yumi Zuhanis Has-Yun Kerr, Philip G. Abbas, Phirdaous Mohd Salleh, Hamzah
author_sort	Hashim, Yumi Zuhanis Has-Yun
title	Aquilaria spp. (agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology
title_short	Aquilaria spp. (agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology
title_full	Aquilaria spp. (agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology
title_fullStr	Aquilaria spp. (agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology
title_full_unstemmed	Aquilaria spp. (agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology
title_sort	aquilaria spp. (agarwood) as source of health beneficial compounds: a review of traditional use, phytochemistry and pharmacology
publishDate	2016
url	http://irep.iium.edu.my/51380/ http://irep.iium.edu.my/51380/ http://irep.iium.edu.my/51380/ http://irep.iium.edu.my/51380/1/Paper_-Hashim_et_al_2016_%28JEP%29.pdf http://irep.iium.edu.my/51380/4/51380_Aquilaria%20spp.%20%28agarwood%29%20as%20source%20of%20health%20beneficial%20compounds_Scopus.pdf
first_indexed	2023-09-18T21:12:44Z
last_indexed	2023-09-18T21:12:44Z
_version_	1777411360620019712

Aquilaria spp. (agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology

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