Kappa antagonist to prevent drug relapse: does stage in addiction cycle matter?

Introduction: An upregulation of the kappa opioid receptor (KOR) system during preoccupation stage in addiction cycle will cause dysphoria among addicts which can lead to relapse. Therefore, KOR antagonism might hold the key to prevent relapse. In this study, we aim to identify the exact addiction&#...

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Main Authors:	Ridzwan, Irna Elina, Zulkifli, Muhammad Harith, Wasli, Nur Syafinaz, Syd Mohmad Faudzi, Syed Mohd Syahmi
Format:	Article
Language:	English English
Published:	International Islamic University Malaysia (IIUM) 2016
Subjects:	RM Therapeutics. Pharmacology RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/51525/ http://irep.iium.edu.my/51525/ http://irep.iium.edu.my/51525/2/MRS-KRD_2016_%28Abstract%29.pdf http://irep.iium.edu.my/51525/6/51525_kappa%20antagonist.pdf

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spelling	iium-515252018-07-02T07:39:34Z http://irep.iium.edu.my/51525/ Kappa antagonist to prevent drug relapse: does stage in addiction cycle matter? Ridzwan, Irna Elina Zulkifli, Muhammad Harith Wasli, Nur Syafinaz Syd Mohmad Faudzi, Syed Mohd Syahmi RM Therapeutics. Pharmacology RS Pharmacy and materia medica Introduction: An upregulation of the kappa opioid receptor (KOR) system during preoccupation stage in addiction cycle will cause dysphoria among addicts which can lead to relapse. Therefore, KOR antagonism might hold the key to prevent relapse. In this study, we aim to identify the exact addiction's stage in which KOR antagonist can be given. Methods: Using a conditioned place preference (CPP) model, adult Swiss albino mice were divided into two major groups. The first group received treatment at the initial stage of morphine withdrawal (7.5 mg/kg. i.p) while the second group received treatment after complete abstinence was achieved. Each major groups were further divided into two treatment groups (n=8-12), either received a functional KOR antagonist (0.3 mg/kg buprenorphine/ 1mg/kg naltrexone combination, i.p) or a selective KOR antagonist (10 mg/kg nor-BNI, i.p) prior to morphine priming (2.5 mg/kg, i.p). All data were analyzed using paired sample t-test. Results: The results showed that relapse was successfully attenuated in the groups that received KOR antagonists only after complete abstinence was successfully achieved (not significantly different from their baseline). However, the mice developed unusual sign of behavior sensitization (intermittent freezing, licking) when buprenorphine/naltrexone combination was given at initial stage of withdrawal. Conclusion: Our initial findings suggest that KOR antagonism might be beneficial only after the addicts achieved complete abstinence to prevent future drug-induced relapse. Brain study should be conducted to explain the unusual behavior seen when the drug intervention is given at an earlier stage of withdrawal. International Islamic University Malaysia (IIUM) 2016-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/51525/2/MRS-KRD_2016_%28Abstract%29.pdf application/pdf en http://irep.iium.edu.my/51525/6/51525_kappa%20antagonist.pdf Ridzwan, Irna Elina and Zulkifli, Muhammad Harith and Wasli, Nur Syafinaz and Syd Mohmad Faudzi, Syed Mohd Syahmi (2016) Kappa antagonist to prevent drug relapse: does stage in addiction cycle matter? International Medical Journal Malaysia, 15 (Supplement issue). p. 67. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/Volume%2015%20Supplement/MRS2016-ABSTRACT-BOOK-67.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RM Therapeutics. Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics. Pharmacology RS Pharmacy and materia medica Ridzwan, Irna Elina Zulkifli, Muhammad Harith Wasli, Nur Syafinaz Syd Mohmad Faudzi, Syed Mohd Syahmi Kappa antagonist to prevent drug relapse: does stage in addiction cycle matter?
description	Introduction: An upregulation of the kappa opioid receptor (KOR) system during preoccupation stage in addiction cycle will cause dysphoria among addicts which can lead to relapse. Therefore, KOR antagonism might hold the key to prevent relapse. In this study, we aim to identify the exact addiction's stage in which KOR antagonist can be given. Methods: Using a conditioned place preference (CPP) model, adult Swiss albino mice were divided into two major groups. The first group received treatment at the initial stage of morphine withdrawal (7.5 mg/kg. i.p) while the second group received treatment after complete abstinence was achieved. Each major groups were further divided into two treatment groups (n=8-12), either received a functional KOR antagonist (0.3 mg/kg buprenorphine/ 1mg/kg naltrexone combination, i.p) or a selective KOR antagonist (10 mg/kg nor-BNI, i.p) prior to morphine priming (2.5 mg/kg, i.p). All data were analyzed using paired sample t-test. Results: The results showed that relapse was successfully attenuated in the groups that received KOR antagonists only after complete abstinence was successfully achieved (not significantly different from their baseline). However, the mice developed unusual sign of behavior sensitization (intermittent freezing, licking) when buprenorphine/naltrexone combination was given at initial stage of withdrawal. Conclusion: Our initial findings suggest that KOR antagonism might be beneficial only after the addicts achieved complete abstinence to prevent future drug-induced relapse. Brain study should be conducted to explain the unusual behavior seen when the drug intervention is given at an earlier stage of withdrawal.
format	Article
author	Ridzwan, Irna Elina Zulkifli, Muhammad Harith Wasli, Nur Syafinaz Syd Mohmad Faudzi, Syed Mohd Syahmi
author_facet	Ridzwan, Irna Elina Zulkifli, Muhammad Harith Wasli, Nur Syafinaz Syd Mohmad Faudzi, Syed Mohd Syahmi
author_sort	Ridzwan, Irna Elina
title	Kappa antagonist to prevent drug relapse: does stage in addiction cycle matter?
title_short	Kappa antagonist to prevent drug relapse: does stage in addiction cycle matter?
title_full	Kappa antagonist to prevent drug relapse: does stage in addiction cycle matter?
title_fullStr	Kappa antagonist to prevent drug relapse: does stage in addiction cycle matter?
title_full_unstemmed	Kappa antagonist to prevent drug relapse: does stage in addiction cycle matter?
title_sort	kappa antagonist to prevent drug relapse: does stage in addiction cycle matter?
publisher	International Islamic University Malaysia (IIUM)
publishDate	2016
url	http://irep.iium.edu.my/51525/ http://irep.iium.edu.my/51525/ http://irep.iium.edu.my/51525/2/MRS-KRD_2016_%28Abstract%29.pdf http://irep.iium.edu.my/51525/6/51525_kappa%20antagonist.pdf
first_indexed	2023-09-18T21:12:57Z
last_indexed	2023-09-18T21:12:57Z
_version_	1777411374035501056

Kappa antagonist to prevent drug relapse: does stage in addiction cycle matter?

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