Low-dose methamphetamine addiction induced opioid receptor sensitization in polydrug-dependent mice

Polydrug dependence shows an increasing trend in prevalence among addicts. It is a result of an addict abusing another drug to mask the undesirable effects of another drug. However, this could lead to adverse neuroadaptations. Therefore, we aim to investigate the effects of low-dose methamphetamine...

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Main Authors:	Ridzwan, Irna Elina, Suhaimi, Maryam Saadah, Muhamad, Abdul Halim, Kasmuri, Abdul Razak, Mohamed Nazar, Nor Ilyani, Hashim, Ridzwan, Syd Mohmad Faudzi, Syed Mohd Syahmi
Format:	Conference or Workshop Item
Language:	English
Published:	Springer 2018
Subjects:	RM Therapeutics. Pharmacology RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/51526/ http://irep.iium.edu.my/51526/ http://irep.iium.edu.my/51526/ http://irep.iium.edu.my/51526/7/51526-Low-dose%20methamphetamine%20addiction.pdf

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spelling	iium-515262018-07-30T06:50:57Z http://irep.iium.edu.my/51526/ Low-dose methamphetamine addiction induced opioid receptor sensitization in polydrug-dependent mice Ridzwan, Irna Elina Suhaimi, Maryam Saadah Muhamad, Abdul Halim Kasmuri, Abdul Razak Mohamed Nazar, Nor Ilyani Hashim, Ridzwan Syd Mohmad Faudzi, Syed Mohd Syahmi RM Therapeutics. Pharmacology RS Pharmacy and materia medica Polydrug dependence shows an increasing trend in prevalence among addicts. It is a result of an addict abusing another drug to mask the undesirable effects of another drug. However, this could lead to adverse neuroadaptations. Therefore, we aim to investigate the effects of low-dose methamphetamine use in morphine-dependent subjects during reinstatement following treatment (0.3 mg/kg buprenorphine / 1.0 mg/kg naltrexone combination) in mice. Using tail-withdrawal assay, the involvement of opioid receptors was investigated at 1.0-5.0 mg/kg methamphetamine, i.p. at 52°C. The results showed that analgesic activity was only detected at the highest dose given which was successfully blocked with 1.0 mg/kg naltrexone, i.p. (p<0.001, n=6). Next, naive mice were randomly divided into three groups (n=at least 12), where the mice were made dependent (p<0.01) to morphine (7.5 mg/kg, i.p.), methamphetamine (1.0 mg/kg, i.p) or morphine/methamphetamine combination (7.5 mg/kg and 1.0 mg/kg respectively). Although relapse was successfully attenuated with non-significant difference compared to baseline, it was found that 6 (out of 13) mice showed sign of opioid receptor sensitization through stereotype and Straub's tail response (>45°) which was not detected in the morphine-, methamphetamine-dependent groups and during pre-screening of treatment drug. This suggest that although methamphetamine has little apparent withdrawal symptoms, it has the ability to sensitize the opioid receptors even at 'inactive' dose when it is used concurrently with morphine. Springer 2018 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/51526/7/51526-Low-dose%20methamphetamine%20addiction.pdf Ridzwan, Irna Elina and Suhaimi, Maryam Saadah and Muhamad, Abdul Halim and Kasmuri, Abdul Razak and Mohamed Nazar, Nor Ilyani and Hashim, Ridzwan and Syd Mohmad Faudzi, Syed Mohd Syahmi (2018) Low-dose methamphetamine addiction induced opioid receptor sensitization in polydrug-dependent mice. In: Regional Conference on Science Technology & Social Sciences (RCSTSS2016), 4th-6th December 2016, Cameron Highlands, Pahang. https://link.springer.com/chapter/10.1007/978-981-13-0074-5_59 10.1007/978-981-13-0074-5_59
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM Therapeutics. Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics. Pharmacology RS Pharmacy and materia medica Ridzwan, Irna Elina Suhaimi, Maryam Saadah Muhamad, Abdul Halim Kasmuri, Abdul Razak Mohamed Nazar, Nor Ilyani Hashim, Ridzwan Syd Mohmad Faudzi, Syed Mohd Syahmi Low-dose methamphetamine addiction induced opioid receptor sensitization in polydrug-dependent mice
description	Polydrug dependence shows an increasing trend in prevalence among addicts. It is a result of an addict abusing another drug to mask the undesirable effects of another drug. However, this could lead to adverse neuroadaptations. Therefore, we aim to investigate the effects of low-dose methamphetamine use in morphine-dependent subjects during reinstatement following treatment (0.3 mg/kg buprenorphine / 1.0 mg/kg naltrexone combination) in mice. Using tail-withdrawal assay, the involvement of opioid receptors was investigated at 1.0-5.0 mg/kg methamphetamine, i.p. at 52°C. The results showed that analgesic activity was only detected at the highest dose given which was successfully blocked with 1.0 mg/kg naltrexone, i.p. (p<0.001, n=6). Next, naive mice were randomly divided into three groups (n=at least 12), where the mice were made dependent (p<0.01) to morphine (7.5 mg/kg, i.p.), methamphetamine (1.0 mg/kg, i.p) or morphine/methamphetamine combination (7.5 mg/kg and 1.0 mg/kg respectively). Although relapse was successfully attenuated with non-significant difference compared to baseline, it was found that 6 (out of 13) mice showed sign of opioid receptor sensitization through stereotype and Straub's tail response (>45°) which was not detected in the morphine-, methamphetamine-dependent groups and during pre-screening of treatment drug. This suggest that although methamphetamine has little apparent withdrawal symptoms, it has the ability to sensitize the opioid receptors even at 'inactive' dose when it is used concurrently with morphine.
format	Conference or Workshop Item
author	Ridzwan, Irna Elina Suhaimi, Maryam Saadah Muhamad, Abdul Halim Kasmuri, Abdul Razak Mohamed Nazar, Nor Ilyani Hashim, Ridzwan Syd Mohmad Faudzi, Syed Mohd Syahmi
author_facet	Ridzwan, Irna Elina Suhaimi, Maryam Saadah Muhamad, Abdul Halim Kasmuri, Abdul Razak Mohamed Nazar, Nor Ilyani Hashim, Ridzwan Syd Mohmad Faudzi, Syed Mohd Syahmi
author_sort	Ridzwan, Irna Elina
title	Low-dose methamphetamine addiction induced opioid receptor sensitization in polydrug-dependent mice
title_short	Low-dose methamphetamine addiction induced opioid receptor sensitization in polydrug-dependent mice
title_full	Low-dose methamphetamine addiction induced opioid receptor sensitization in polydrug-dependent mice
title_fullStr	Low-dose methamphetamine addiction induced opioid receptor sensitization in polydrug-dependent mice
title_full_unstemmed	Low-dose methamphetamine addiction induced opioid receptor sensitization in polydrug-dependent mice
title_sort	low-dose methamphetamine addiction induced opioid receptor sensitization in polydrug-dependent mice
publisher	Springer
publishDate	2018
url	http://irep.iium.edu.my/51526/ http://irep.iium.edu.my/51526/ http://irep.iium.edu.my/51526/ http://irep.iium.edu.my/51526/7/51526-Low-dose%20methamphetamine%20addiction.pdf
first_indexed	2023-09-18T21:12:57Z
last_indexed	2023-09-18T21:12:57Z
_version_	1777411374181253120

Low-dose methamphetamine addiction induced opioid receptor sensitization in polydrug-dependent mice

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