Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration

Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer’s disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteri...

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Main Authors:	Abdul Majeed, Saif Saad, Saxena, Anil Kumar
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	R Medicine (General) RM214 Diet therapy. Diet and dietectics in disease
Online Access:	http://irep.iium.edu.my/5167/ http://irep.iium.edu.my/5167/ http://irep.iium.edu.my/5167/1/poster_101_iriie_2011.pdf

id	iium-5167
recordtype	eprints
spelling	iium-51672011-11-21T16:19:38Z http://irep.iium.edu.my/5167/ Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration Abdul Majeed, Saif Saad Saxena, Anil Kumar R Medicine (General) RM214 Diet therapy. Diet and dietectics in disease Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer’s disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteries (2-vessel occlusion, 2VO) in rats. Since oxidative stress, leading to neuronal apoptosis and death, is one of the mechanisms which is thought to play a significant role in chronic degenerative neurological disorders, the present study was planned to assess the alterations in oxidative and anti-oxidant mechanisms that might occur during chronic cerebral hypoperfusion. Malondialdehyde (MDA) concentration and antioxidant enzymes namely glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase were measured in the brain tissue after eight weeks of 2VO induction in rats. Results show an increased level of oxidative stress as reflected by significantly elevated levels of MDA, GPx, SOD, and catalase enzymes as compared with the control group. It is possible that compensatory rise in antioxidant enzymes occurs in response to increased oxidative stress following ischemic insult. 2011-02 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/5167/1/poster_101_iriie_2011.pdf Abdul Majeed, Saif Saad and Saxena, Anil Kumar (2011) Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration. In: Enhancing Quality Research and Innovation for Societal Development, 9-10 February 2011, IIUM, Gombak. http://iium.edu.my
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RM214 Diet therapy. Diet and dietectics in disease
spellingShingle	R Medicine (General) RM214 Diet therapy. Diet and dietectics in disease Abdul Majeed, Saif Saad Saxena, Anil Kumar Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration
description	Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer’s disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteries (2-vessel occlusion, 2VO) in rats. Since oxidative stress, leading to neuronal apoptosis and death, is one of the mechanisms which is thought to play a significant role in chronic degenerative neurological disorders, the present study was planned to assess the alterations in oxidative and anti-oxidant mechanisms that might occur during chronic cerebral hypoperfusion. Malondialdehyde (MDA) concentration and antioxidant enzymes namely glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase were measured in the brain tissue after eight weeks of 2VO induction in rats. Results show an increased level of oxidative stress as reflected by significantly elevated levels of MDA, GPx, SOD, and catalase enzymes as compared with the control group. It is possible that compensatory rise in antioxidant enzymes occurs in response to increased oxidative stress following ischemic insult.
format	Conference or Workshop Item
author	Abdul Majeed, Saif Saad Saxena, Anil Kumar
author_facet	Abdul Majeed, Saif Saad Saxena, Anil Kumar
author_sort	Abdul Majeed, Saif Saad
title	Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration
title_short	Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration
title_full	Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration
title_fullStr	Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration
title_full_unstemmed	Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration
title_sort	assessment of reactive oxygen species (ros) status in chronic cerebral hypoperfusion-induced neurodegeneration
publishDate	2011
url	http://irep.iium.edu.my/5167/ http://irep.iium.edu.my/5167/ http://irep.iium.edu.my/5167/1/poster_101_iriie_2011.pdf
first_indexed	2023-09-18T20:13:38Z
last_indexed	2023-09-18T20:13:38Z
_version_	1777407642894860288

Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration

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