Synthesis 4-[2-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-ethyl]-benzenesulfonamides with subnanomolar carbonic anhydrase II and XII inhibitory properties
Condensation of substituted anthranilic acids with 4-isothiocyanatoethyl-benzenesulfonamide led to series of heterocyclic benzenesulfonamides incorporating 2-mercapto-quinazolin-4-one tails. These sulfonamides were investigated as inhibitors of the human carbonic anhydrase (hCA, EC 4.2.1.1) isofor...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English English English |
| Published: |
Elsevier
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/51705/ http://irep.iium.edu.my/51705/ http://irep.iium.edu.my/51705/ http://irep.iium.edu.my/51705/1/2016_4100-4107.pdf http://irep.iium.edu.my/51705/4/51705_benzenesulfonamides%20with%20subnanomolar%20carbonic_Scopus.pdf http://irep.iium.edu.my/51705/5/51705_benzenesulfonamides%20with%20subnanomolar%20carbonic_WoS.pdf |