Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view

Self-emulsifying drug delivery system (SEDDS) is an isotropic mixture of lipid, surfactant and co-surfactant, which forms a fine emulsion when comes in contact of an aqueous medium with mild agitation. SEDDS is considered as a potential platform for oral delivery of hydrophobic drug in order to o...

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Main Authors:	Chatterjee, Bappaditya, Hamed Almuris, Samah, Ahmed Mahdi Dukhan, Ather, Mandal, Uttam Kumar Umar, Sengupta, Pinaki
Format:	Article
Language:	English English English
Published:	Taylor and Francis Ltd 2016
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/51870/ http://irep.iium.edu.my/51870/ http://irep.iium.edu.my/51870/ http://irep.iium.edu.my/51870/4/51870_Controversies.pdf http://irep.iium.edu.my/51870/5/51870_Controversies_WOS.pdf http://irep.iium.edu.my/51870/6/51870_Controversies_SCOPUS.pdf

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spelling	iium-518702017-05-31T03:23:57Z http://irep.iium.edu.my/51870/ Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view Chatterjee, Bappaditya Hamed Almuris, Samah Ahmed Mahdi Dukhan, Ather Mandal, Uttam Kumar Umar Sengupta, Pinaki RS Pharmacy and materia medica Self-emulsifying drug delivery system (SEDDS) is an isotropic mixture of lipid, surfactant and co-surfactant, which forms a fine emulsion when comes in contact of an aqueous medium with mild agitation. SEDDS is considered as a potential platform for oral delivery of hydrophobic drug in order to overcome their poor and irregular bioavailability challenges. In spite of fewer advantages like improved solubility of drug, bypassing lymphatic transport etc., SEDDS faces different controversial issues such as the use of appropriate terminology (self-microemulsifying drug delivery system; SMEDDS or self-nanoemulsifying drug delivery system; SNEDDS), presence of high amount of surfactant, correlation of in vitro model to in vivo studies, lack of human volunteer study and effect of conversion of SEDDS to final administrable dosage form on pharmacokinetic behavior of the drug. In this review, potential issues or questions on SEDDS are identified and summarized from the pharmacokinetic point of view. Primarily this review includes the conflict between the influences of droplet size, variation in correlation between in vitro lipolysis or ex-vivo intestinal permeation and pharmacokinetic parameters, variation in in vivo results of solid and liquid SEDDS, and potential challenges or limitation of pharmacokinetic studies on human volunteers with orally administered SEDDS. In the past decades, hundreds of in vivo studies on SEDDS have been published. In the present study, only the relevant article on in vivo pharmacokinetic studies with orally administered SEDDS published in past 5–6 years are analyzed for an up to date compilation. Taylor and Francis Ltd 2016-11-21 Article PeerReviewed application/pdf en http://irep.iium.edu.my/51870/4/51870_Controversies.pdf application/pdf en http://irep.iium.edu.my/51870/5/51870_Controversies_WOS.pdf application/pdf en http://irep.iium.edu.my/51870/6/51870_Controversies_SCOPUS.pdf Chatterjee, Bappaditya and Hamed Almuris, Samah and Ahmed Mahdi Dukhan, Ather and Mandal, Uttam Kumar Umar and Sengupta, Pinaki (2016) Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view. Drug Delivery, 23 (9). pp. 3639-3652. ISSN 1071-7544 E-ISSN 1521-0464 http://www.tandfonline.com/doi/pdf/10.1080/10717544.2016.1214990?needAccess=true 10.1080/10717544.2016.1214990
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Chatterjee, Bappaditya Hamed Almuris, Samah Ahmed Mahdi Dukhan, Ather Mandal, Uttam Kumar Umar Sengupta, Pinaki Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view
description	Self-emulsifying drug delivery system (SEDDS) is an isotropic mixture of lipid, surfactant and co-surfactant, which forms a fine emulsion when comes in contact of an aqueous medium with mild agitation. SEDDS is considered as a potential platform for oral delivery of hydrophobic drug in order to overcome their poor and irregular bioavailability challenges. In spite of fewer advantages like improved solubility of drug, bypassing lymphatic transport etc., SEDDS faces different controversial issues such as the use of appropriate terminology (self-microemulsifying drug delivery system; SMEDDS or self-nanoemulsifying drug delivery system; SNEDDS), presence of high amount of surfactant, correlation of in vitro model to in vivo studies, lack of human volunteer study and effect of conversion of SEDDS to final administrable dosage form on pharmacokinetic behavior of the drug. In this review, potential issues or questions on SEDDS are identified and summarized from the pharmacokinetic point of view. Primarily this review includes the conflict between the influences of droplet size, variation in correlation between in vitro lipolysis or ex-vivo intestinal permeation and pharmacokinetic parameters, variation in in vivo results of solid and liquid SEDDS, and potential challenges or limitation of pharmacokinetic studies on human volunteers with orally administered SEDDS. In the past decades, hundreds of in vivo studies on SEDDS have been published. In the present study, only the relevant article on in vivo pharmacokinetic studies with orally administered SEDDS published in past 5–6 years are analyzed for an up to date compilation.
format	Article
author	Chatterjee, Bappaditya Hamed Almuris, Samah Ahmed Mahdi Dukhan, Ather Mandal, Uttam Kumar Umar Sengupta, Pinaki
author_facet	Chatterjee, Bappaditya Hamed Almuris, Samah Ahmed Mahdi Dukhan, Ather Mandal, Uttam Kumar Umar Sengupta, Pinaki
author_sort	Chatterjee, Bappaditya
title	Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view
title_short	Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view
title_full	Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view
title_fullStr	Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view
title_full_unstemmed	Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view
title_sort	controversies with self-emulsifying drug delivery system from pharmacokinetic point of view
publisher	Taylor and Francis Ltd
publishDate	2016
url	http://irep.iium.edu.my/51870/ http://irep.iium.edu.my/51870/ http://irep.iium.edu.my/51870/ http://irep.iium.edu.my/51870/4/51870_Controversies.pdf http://irep.iium.edu.my/51870/5/51870_Controversies_WOS.pdf http://irep.iium.edu.my/51870/6/51870_Controversies_SCOPUS.pdf
first_indexed	2023-09-18T21:13:32Z
last_indexed	2023-09-18T21:13:32Z
_version_	1777411410991513600

Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view

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