Subchondral bone plate changes more rapidly than trabecular bone in osteoarthritis

Osteoarthritis (OA) is the most common joint disorder, characterised by focal loss of cartilage and increased subchondral bone remodelling at early OA stages of the disease. We have investigated the temporal and the spatial relationship between bone remodelling in subchondral bone plate (Sbp) and tr...

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Main Authors:	Zamli, Zaitunnatakhin, Robson Brown, Kate, Sharif, Mohammed
Format:	Article
Language:	English
Published:	2016
Subjects:	RD701 Orthopedics
Online Access:	http://irep.iium.edu.my/51980/ http://irep.iium.edu.my/51980/ http://irep.iium.edu.my/51980/ http://irep.iium.edu.my/51980/1/Subchondral%20Bone%20Plate%20Changes%20More%20Rapidly%20than%20Trabecular%20bone%20in%20Osteoarthritis.pdf

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spelling	iium-519802017-01-04T10:29:39Z http://irep.iium.edu.my/51980/ Subchondral bone plate changes more rapidly than trabecular bone in osteoarthritis Zamli, Zaitunnatakhin Robson Brown, Kate Sharif, Mohammed RD701 Orthopedics Osteoarthritis (OA) is the most common joint disorder, characterised by focal loss of cartilage and increased subchondral bone remodelling at early OA stages of the disease. We have investigated the temporal and the spatial relationship between bone remodelling in subchondral bone plate (Sbp) and trabecular bone (Tb) in Dunkin Hartley (DH, develop OA early) and the Bristol Strain 2 (BS2, control which develop OA late) guinea pigs. Right tibias were dissected from six male animals of each strain, at 10, 16, 24 and 30 weeks of age. Micro-computed tomography was used to quantify the growth plate thickness (GpTh), subchondral bone plate thickness (SbpTh) and trabecular bone thickness (TbTh), and bone mineral density (BMD) in both Sbp and Tb. The rate of change was calculated for 10–16 weeks, 16–24 weeks and 24–30 weeks. The rate of changes in Sbp and Tb thickness at the earliest time interval (10–16 weeks) were significantly greater in DH guinea pigs than in the growth-matched control strain (BS2). The magnitude of these differences was greater in the medial side than the lateral side (DH: 22.7 and 14.75 µm/week, BS2: 5.63 and 6.67 µm/week, respectively). Similarly, changes in the BMD at the earliest time interval was greater in the DH strain than the BS2, again more pronounced in the disease prone medial compartment (DH: 0.0698 and 0.0372 g/cm3/week, BS2: 0.00457 and 0.00772 g/cm3/week, respectively). These changes observed preceded microscopic and cellular signs of disease as previously reported. The rapid early changes in SbpTh, TbTh, Sbp BMD and Tb BMD in the disease prone DH guinea pigs compared with the BS2 control strain suggest a link to early OA pathology. This is corroborated by the greater relative changes in subchondral bone in the medial compared with the lateral compartment. 2016-09-07 Article PeerReviewed application/pdf en http://irep.iium.edu.my/51980/1/Subchondral%20Bone%20Plate%20Changes%20More%20Rapidly%20than%20Trabecular%20bone%20in%20Osteoarthritis.pdf Zamli, Zaitunnatakhin and Robson Brown, Kate and Sharif, Mohammed (2016) Subchondral bone plate changes more rapidly than trabecular bone in osteoarthritis. International Journal of Molecular Sciences, 17 (9). pp. 1-11. ISSN 1661-6596 E-ISSN 1422-0067 http://www.mdpi.com/1422-0067/17/9/1496/htm 10.3390/ijms17091496
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RD701 Orthopedics
spellingShingle	RD701 Orthopedics Zamli, Zaitunnatakhin Robson Brown, Kate Sharif, Mohammed Subchondral bone plate changes more rapidly than trabecular bone in osteoarthritis
description	Osteoarthritis (OA) is the most common joint disorder, characterised by focal loss of cartilage and increased subchondral bone remodelling at early OA stages of the disease. We have investigated the temporal and the spatial relationship between bone remodelling in subchondral bone plate (Sbp) and trabecular bone (Tb) in Dunkin Hartley (DH, develop OA early) and the Bristol Strain 2 (BS2, control which develop OA late) guinea pigs. Right tibias were dissected from six male animals of each strain, at 10, 16, 24 and 30 weeks of age. Micro-computed tomography was used to quantify the growth plate thickness (GpTh), subchondral bone plate thickness (SbpTh) and trabecular bone thickness (TbTh), and bone mineral density (BMD) in both Sbp and Tb. The rate of change was calculated for 10–16 weeks, 16–24 weeks and 24–30 weeks. The rate of changes in Sbp and Tb thickness at the earliest time interval (10–16 weeks) were significantly greater in DH guinea pigs than in the growth-matched control strain (BS2). The magnitude of these differences was greater in the medial side than the lateral side (DH: 22.7 and 14.75 µm/week, BS2: 5.63 and 6.67 µm/week, respectively). Similarly, changes in the BMD at the earliest time interval was greater in the DH strain than the BS2, again more pronounced in the disease prone medial compartment (DH: 0.0698 and 0.0372 g/cm3/week, BS2: 0.00457 and 0.00772 g/cm3/week, respectively). These changes observed preceded microscopic and cellular signs of disease as previously reported. The rapid early changes in SbpTh, TbTh, Sbp BMD and Tb BMD in the disease prone DH guinea pigs compared with the BS2 control strain suggest a link to early OA pathology. This is corroborated by the greater relative changes in subchondral bone in the medial compared with the lateral compartment.
format	Article
author	Zamli, Zaitunnatakhin Robson Brown, Kate Sharif, Mohammed
author_facet	Zamli, Zaitunnatakhin Robson Brown, Kate Sharif, Mohammed
author_sort	Zamli, Zaitunnatakhin
title	Subchondral bone plate changes more rapidly than trabecular bone in osteoarthritis
title_short	Subchondral bone plate changes more rapidly than trabecular bone in osteoarthritis
title_full	Subchondral bone plate changes more rapidly than trabecular bone in osteoarthritis
title_fullStr	Subchondral bone plate changes more rapidly than trabecular bone in osteoarthritis
title_full_unstemmed	Subchondral bone plate changes more rapidly than trabecular bone in osteoarthritis
title_sort	subchondral bone plate changes more rapidly than trabecular bone in osteoarthritis
publishDate	2016
url	http://irep.iium.edu.my/51980/ http://irep.iium.edu.my/51980/ http://irep.iium.edu.my/51980/ http://irep.iium.edu.my/51980/1/Subchondral%20Bone%20Plate%20Changes%20More%20Rapidly%20than%20Trabecular%20bone%20in%20Osteoarthritis.pdf
first_indexed	2023-09-18T21:13:42Z
last_indexed	2023-09-18T21:13:42Z
_version_	1777411421721591808

Subchondral bone plate changes more rapidly than trabecular bone in osteoarthritis

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