Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres

Biodegradable poly(lactide-co-glycolide) (PLGA) microspheres have received much attention over the last twenty-five years for controlled parenteral delivery of therapeutic protein and peptide drugs [1, 2]. In general, for protein drugs delivery, PLGA and PLGA-based single-polymer microspheres system...

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Main Authors:	Rahman, Md. Mokhlesur, Ansary, R.H., Mohamed, Farahidah, Kasmuri, Abdul Razak, Md. Aris, Mohd. Aznan, Katas, H, Awang, M.B.
Format:	Conference or Workshop Item
Language:	English English
Published:	2016
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/52222/ http://irep.iium.edu.my/52222/2/participation%20Cert.%20scan.jpg http://irep.iium.edu.my/52222/13/52222.pdf

id	iium-52222
recordtype	eprints
spelling	iium-522222016-10-12T06:33:47Z http://irep.iium.edu.my/52222/ Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres Rahman, Md. Mokhlesur Ansary, R.H. Mohamed, Farahidah Kasmuri, Abdul Razak Md. Aris, Mohd. Aznan Katas, H Awang, M.B. QD Chemistry Biodegradable poly(lactide-co-glycolide) (PLGA) microspheres have received much attention over the last twenty-five years for controlled parenteral delivery of therapeutic protein and peptide drugs [1, 2]. In general, for protein drugs delivery, PLGA and PLGA-based single-polymer microspheres system still suffer from two major technical problems associated with their inherent stability problem [3]. Initial burst release followed by very slow and incomplete release is one of the most serious problems in the formulation of PLGA-based protein drugs delivery system. Many strategies have been explored currently to reduce the high initial burst release of protein and peptide drugs from PLGA microspheres [4]. Fabrication of double-walled microspheres in which protein drugs encapsulated in the inner core surrounded by a drug free outer polymer layer offers a promising technique in reducing the high initial burst release. In previous studies, large size double-walled microspheres have been prepared using poly(L-lactic acid) (PLLA) and different co-polymers of PLGA (ester-terminated and carboxyl-terminated) as the core and shell material. Double-walled microspheres consisting PLLA and ester-terminated PLGA as the core or shell material required more time for the complete release of encapsulated drugs due to the slow degrading nature of these polymers. 2016 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/52222/2/participation%20Cert.%20scan.jpg application/pdf en http://irep.iium.edu.my/52222/13/52222.pdf Rahman, Md. Mokhlesur and Ansary, R.H. and Mohamed, Farahidah and Kasmuri, Abdul Razak and Md. Aris, Mohd. Aznan and Katas, H and Awang, M.B. (2016) Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres. In: International Conference on Industrial Pharmacy (2nd ICIP 2016), 15th-16th Aug. 2016, Kuantan, Pahang. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QD Chemistry
spellingShingle	QD Chemistry Rahman, Md. Mokhlesur Ansary, R.H. Mohamed, Farahidah Kasmuri, Abdul Razak Md. Aris, Mohd. Aznan Katas, H Awang, M.B. Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres
description	Biodegradable poly(lactide-co-glycolide) (PLGA) microspheres have received much attention over the last twenty-five years for controlled parenteral delivery of therapeutic protein and peptide drugs [1, 2]. In general, for protein drugs delivery, PLGA and PLGA-based single-polymer microspheres system still suffer from two major technical problems associated with their inherent stability problem [3]. Initial burst release followed by very slow and incomplete release is one of the most serious problems in the formulation of PLGA-based protein drugs delivery system. Many strategies have been explored currently to reduce the high initial burst release of protein and peptide drugs from PLGA microspheres [4]. Fabrication of double-walled microspheres in which protein drugs encapsulated in the inner core surrounded by a drug free outer polymer layer offers a promising technique in reducing the high initial burst release. In previous studies, large size double-walled microspheres have been prepared using poly(L-lactic acid) (PLLA) and different co-polymers of PLGA (ester-terminated and carboxyl-terminated) as the core and shell material. Double-walled microspheres consisting PLLA and ester-terminated PLGA as the core or shell material required more time for the complete release of encapsulated drugs due to the slow degrading nature of these polymers.
format	Conference or Workshop Item
author	Rahman, Md. Mokhlesur Ansary, R.H. Mohamed, Farahidah Kasmuri, Abdul Razak Md. Aris, Mohd. Aznan Katas, H Awang, M.B.
author_facet	Rahman, Md. Mokhlesur Ansary, R.H. Mohamed, Farahidah Kasmuri, Abdul Razak Md. Aris, Mohd. Aznan Katas, H Awang, M.B.
author_sort	Rahman, Md. Mokhlesur
title	Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres
title_short	Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres
title_full	Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres
title_fullStr	Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres
title_full_unstemmed	Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres
title_sort	effect of process variables on the preparation of bsa loaded double-walled poly(lactide-co-glycolide) microspheres
publishDate	2016
url	http://irep.iium.edu.my/52222/ http://irep.iium.edu.my/52222/2/participation%20Cert.%20scan.jpg http://irep.iium.edu.my/52222/13/52222.pdf
first_indexed	2023-09-18T21:14:01Z
last_indexed	2023-09-18T21:14:01Z
_version_	1777411441397071872

Effect of process variables on the preparation of BSA loaded double-walled poly(lactide-co-glycolide) microspheres

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