Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers

To examine the effect of cryopreservation on developmental potential of human embryos, this study compared quantitative β-HCG concentrations at pregnancy test after IVF-fresh embryo transfer (IVF-ET) with those arising after frozen embryo transfer (FET). It also tracked outcomes of singleton pregnan...

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Main Authors:	Keane, Kevin N, Mustafa, Kamarul Bahyah, Hinchliffe, Peter, Conceicao, Jason, Yovich, John L
Format:	Article
Language:	English English
Published:	Elsevier Ltd 2016
Subjects:	RG Gynecology and obstetrics
Online Access:	http://irep.iium.edu.my/52266/ http://irep.iium.edu.my/52266/ http://irep.iium.edu.my/52266/ http://irep.iium.edu.my/52266/1/52266_Higher%20HCG.pdf http://irep.iium.edu.my/52266/2/52266_Higher%20%CE%B2-HCG_SCOPUS.pdf

id	iium-52266
recordtype	eprints
spelling	iium-522662017-06-05T03:35:31Z http://irep.iium.edu.my/52266/ Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers Keane, Kevin N Mustafa, Kamarul Bahyah Hinchliffe, Peter Conceicao, Jason Yovich, John L RG Gynecology and obstetrics To examine the effect of cryopreservation on developmental potential of human embryos, this study compared quantitative β-HCG concentrations at pregnancy test after IVF-fresh embryo transfer (IVF-ET) with those arising after frozen embryo transfer (FET). It also tracked outcomes of singleton pregnancies resulting from single-embryo transfers that resulted in singleton live births (n = 869; with 417 derived from IVF-ET and 452 from FET). The initial serum β-HCG concentration indicating successful implantation was measured along with the birthweight of the ensuing infants. With testing at equivalent luteal phase lengths, the median pregnancy test β-HCG was significantly higher following FET compared with fresh IVF-ET (844.5 IU/l versus 369 IU/l; P < 0.001). Despite no significant difference in the average period of gestation (38 weeks 5 days for both groups), the mean birthweight of infants born following FET was significantly heavier by 161 g (3370 g versus 3209 g; P < 0.001). Furthermore, more infants exceeded 4000 g (P < 0.001) for FET although there was no significant difference for the macrosomic category (≥4500 g). We concluded that FET programme embryos lead to infants with equivalent (if not better) developmental potential compared with IVF-ET, demonstrated by higher pregnancy β-HCG concentrations and ensuing birthweights. Elsevier Ltd 2016-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/52266/1/52266_Higher%20HCG.pdf application/pdf en http://irep.iium.edu.my/52266/2/52266_Higher%20%CE%B2-HCG_SCOPUS.pdf Keane, Kevin N and Mustafa, Kamarul Bahyah and Hinchliffe, Peter and Conceicao, Jason and Yovich, John L (2016) Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers. Reproductive BioMedicine Online, 33 (2). pp. 149-160. ISSN 1472-6483 http://www.sciencedirect.com/science/article/pii/S1472648316302905 10.1016/j.rbmo.2016.04.014
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RG Gynecology and obstetrics
spellingShingle	RG Gynecology and obstetrics Keane, Kevin N Mustafa, Kamarul Bahyah Hinchliffe, Peter Conceicao, Jason Yovich, John L Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers
description	To examine the effect of cryopreservation on developmental potential of human embryos, this study compared quantitative β-HCG concentrations at pregnancy test after IVF-fresh embryo transfer (IVF-ET) with those arising after frozen embryo transfer (FET). It also tracked outcomes of singleton pregnancies resulting from single-embryo transfers that resulted in singleton live births (n = 869; with 417 derived from IVF-ET and 452 from FET). The initial serum β-HCG concentration indicating successful implantation was measured along with the birthweight of the ensuing infants. With testing at equivalent luteal phase lengths, the median pregnancy test β-HCG was significantly higher following FET compared with fresh IVF-ET (844.5 IU/l versus 369 IU/l; P < 0.001). Despite no significant difference in the average period of gestation (38 weeks 5 days for both groups), the mean birthweight of infants born following FET was significantly heavier by 161 g (3370 g versus 3209 g; P < 0.001). Furthermore, more infants exceeded 4000 g (P < 0.001) for FET although there was no significant difference for the macrosomic category (≥4500 g). We concluded that FET programme embryos lead to infants with equivalent (if not better) developmental potential compared with IVF-ET, demonstrated by higher pregnancy β-HCG concentrations and ensuing birthweights.
format	Article
author	Keane, Kevin N Mustafa, Kamarul Bahyah Hinchliffe, Peter Conceicao, Jason Yovich, John L
author_facet	Keane, Kevin N Mustafa, Kamarul Bahyah Hinchliffe, Peter Conceicao, Jason Yovich, John L
author_sort	Keane, Kevin N
title	Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers
title_short	Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers
title_full	Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers
title_fullStr	Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers
title_full_unstemmed	Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers
title_sort	higher β-hcg concentrations and higher birthweights ensue from single vitrified embryo transfers
publisher	Elsevier Ltd
publishDate	2016
url	http://irep.iium.edu.my/52266/ http://irep.iium.edu.my/52266/ http://irep.iium.edu.my/52266/ http://irep.iium.edu.my/52266/1/52266_Higher%20HCG.pdf http://irep.iium.edu.my/52266/2/52266_Higher%20%CE%B2-HCG_SCOPUS.pdf
first_indexed	2023-09-18T21:14:04Z
last_indexed	2023-09-18T21:14:04Z
_version_	1777411444885684224

Higher β-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers

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