Does endogenous serum oestrogen play a role in meibomian gland dysfunction in postmenopausal women with dry eye?
Aim To explore the relationship between serum concentration of sex hormones and dry eye symptoms and signs in postmenopausal women. Methods A cross-sectional analysis was undertaken. Subjects were 46 postmenopausal women with dry eye (mean age 64.4±5.2 years, 13.7±6.4 years since menopause; no...
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2016
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| Online Access: | http://irep.iium.edu.my/52736/ http://irep.iium.edu.my/52736/ http://irep.iium.edu.my/52736/ http://irep.iium.edu.my/52736/1/Br%20J%20Ophthalmol-2016-Golebiowski-bjophthalmol-2016-308473.pdf |
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iium-527362016-11-17T08:06:49Z http://irep.iium.edu.my/52736/ Does endogenous serum oestrogen play a role in meibomian gland dysfunction in postmenopausal women with dry eye? Blanka Golebiowski, Blanka Noor Badarudin, Noor Ezailina John Eden, John You, Jingjing Hampel, Ulrike Stapleton, Fiona RE Ophthalmology Aim To explore the relationship between serum concentration of sex hormones and dry eye symptoms and signs in postmenopausal women. Methods A cross-sectional analysis was undertaken. Subjects were 46 postmenopausal women with dry eye (mean age 64.4±5.2 years, 13.7±6.4 years since menopause; not undergoing hormone replacement therapy). Ocular symptoms (Ocular Surface Disease Index (OSDI) and Ocular Comfort Index (OCI)), tear function (tear osmolarity, non-invasive tear break-up time, tear secretion), corneal and conjunctival staining, and meibomian gland (MG) appearance, were recorded. Venous blood was collected and serum concentrations of 17β-oestradiol (E2), 3-α-androstanediol-glucuronide (3α-diol-G), and dehydroepiandrosterone sulfate (DHEAS) were determined using ELISA. Multiple linear regression analysis was used to examine predictors of dry eye symptoms and signs. Results Mean serum concentration of E2, 3α-diol-G and DHEA-S was 9.02±13.40 pg/mL, 1.59±1.02 ng/mL and 0.74±0.53 μg/mL, respectively. Ocular symptoms were elevated (mean scores 27.0±18.1 (OSDI) and 40.3 ±8.4 (OCI)) but signs were within normal ranges. Higher serum E2 concentration along with capped glands, lid telangiectasia and older age was a significant predictor of worse MG secretion quality (p<0.001, R2 adj=0.75). Serum hormones were not significant predictors of ocular symptoms in multivariate analysis (p>0.05). Conclusion Serum oestrogen appears to be a key factor in MG signs. Although serum hormone levels did not contribute significantly to dry eye symptoms in this study, it is possible that oestrogen plays a role through its effect on meibum secretion. These findings suggest that MG dysfunction underpins dry eye symptoms in non-Sjögren’s dry eye in postmenopausal women 2016-04-13 Article PeerReviewed application/pdf en http://irep.iium.edu.my/52736/1/Br%20J%20Ophthalmol-2016-Golebiowski-bjophthalmol-2016-308473.pdf Blanka Golebiowski, Blanka and Noor Badarudin, Noor Ezailina and John Eden, John and You, Jingjing and Hampel, Ulrike and Stapleton, Fiona (2016) Does endogenous serum oestrogen play a role in meibomian gland dysfunction in postmenopausal women with dry eye? British Journal of Ophthalmology. ISSN 1468-2079 (In Press) http://bjo.bmj.com/content/early/2016/04/13/bjophthalmol-2016-308473 10.1136/bjophthalmol-2016-308473 |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
RE Ophthalmology |
| spellingShingle |
RE Ophthalmology Blanka Golebiowski, Blanka Noor Badarudin, Noor Ezailina John Eden, John You, Jingjing Hampel, Ulrike Stapleton, Fiona Does endogenous serum oestrogen play a role in meibomian gland dysfunction in postmenopausal women with dry eye? |
| description |
Aim To explore the relationship between serum
concentration of sex hormones and dry eye symptoms
and signs in postmenopausal women.
Methods A cross-sectional analysis was undertaken.
Subjects were 46 postmenopausal women with dry eye
(mean age 64.4±5.2 years, 13.7±6.4 years since
menopause; not undergoing hormone replacement
therapy). Ocular symptoms (Ocular Surface Disease Index
(OSDI) and Ocular Comfort Index (OCI)), tear function
(tear osmolarity, non-invasive tear break-up time, tear
secretion), corneal and conjunctival staining, and
meibomian gland (MG) appearance, were recorded.
Venous blood was collected and serum concentrations of
17β-oestradiol (E2), 3-α-androstanediol-glucuronide
(3α-diol-G), and dehydroepiandrosterone sulfate (DHEAS)
were determined using ELISA. Multiple linear
regression analysis was used to examine predictors of
dry eye symptoms and signs.
Results Mean serum concentration of E2, 3α-diol-G
and DHEA-S was 9.02±13.40 pg/mL, 1.59±1.02 ng/mL
and 0.74±0.53 μg/mL, respectively. Ocular symptoms
were elevated (mean scores 27.0±18.1 (OSDI) and 40.3
±8.4 (OCI)) but signs were within normal ranges. Higher
serum E2 concentration along with capped glands, lid
telangiectasia and older age was a significant predictor
of worse MG secretion quality (p<0.001, R2
adj=0.75).
Serum hormones were not significant predictors of ocular
symptoms in multivariate analysis (p>0.05).
Conclusion Serum oestrogen appears to be a key
factor in MG signs. Although serum hormone levels did
not contribute significantly to dry eye symptoms in this
study, it is possible that oestrogen plays a role through
its effect on meibum secretion. These findings suggest
that MG dysfunction underpins dry eye symptoms in
non-Sjögren’s dry eye in postmenopausal women |
| format |
Article |
| author |
Blanka Golebiowski, Blanka Noor Badarudin, Noor Ezailina John Eden, John You, Jingjing Hampel, Ulrike Stapleton, Fiona |
| author_facet |
Blanka Golebiowski, Blanka Noor Badarudin, Noor Ezailina John Eden, John You, Jingjing Hampel, Ulrike Stapleton, Fiona |
| author_sort |
Blanka Golebiowski, Blanka |
| title |
Does endogenous serum oestrogen play a role in
meibomian gland dysfunction in postmenopausal
women with dry eye? |
| title_short |
Does endogenous serum oestrogen play a role in
meibomian gland dysfunction in postmenopausal
women with dry eye? |
| title_full |
Does endogenous serum oestrogen play a role in
meibomian gland dysfunction in postmenopausal
women with dry eye? |
| title_fullStr |
Does endogenous serum oestrogen play a role in
meibomian gland dysfunction in postmenopausal
women with dry eye? |
| title_full_unstemmed |
Does endogenous serum oestrogen play a role in
meibomian gland dysfunction in postmenopausal
women with dry eye? |
| title_sort |
does endogenous serum oestrogen play a role in
meibomian gland dysfunction in postmenopausal
women with dry eye? |
| publishDate |
2016 |
| url |
http://irep.iium.edu.my/52736/ http://irep.iium.edu.my/52736/ http://irep.iium.edu.my/52736/ http://irep.iium.edu.my/52736/1/Br%20J%20Ophthalmol-2016-Golebiowski-bjophthalmol-2016-308473.pdf |
| first_indexed |
2023-09-18T21:14:42Z |
| last_indexed |
2023-09-18T21:14:42Z |
| _version_ |
1777411484584771584 |