Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration

Honey has shown potential therapeutic properties in traditional medicine. This study investigated the cognition enhancing potential of Tualang honey in chronic cerebral hypoperfusion- induced neurodegeneration by permanent bilateral common carotid arteries ligation (2 vessels occlusion- 2VO) in rats...

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Main Authors:	Saxena, Anil Kumar, Phyu, Hnin Pwint, Al-Ani, Imad Matloub Dally, Syed Ahmad, Pakeer Oothuman
Format:	Article
Language:	English
Published:	Open Access Text ( OAT) 2016
Subjects:	R Medicine (General) RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/52926/ http://irep.iium.edu.my/52926/ http://irep.iium.edu.my/52926/ http://irep.iium.edu.my/52926/1/Anil%20-%20JTS%202016.pdf

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recordtype	eprints
spelling	iium-529262017-10-16T02:49:48Z http://irep.iium.edu.my/52926/ Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration Saxena, Anil Kumar Phyu, Hnin Pwint Al-Ani, Imad Matloub Dally Syed Ahmad, Pakeer Oothuman R Medicine (General) RM Therapeutics. Pharmacology Honey has shown potential therapeutic properties in traditional medicine. This study investigated the cognition enhancing potential of Tualang honey in chronic cerebral hypoperfusion- induced neurodegeneration by permanent bilateral common carotid arteries ligation (2 vessels occlusion- 2VO) in rats. Previous studies have shown that rats subjected to 2VO (2 vessel occlusion) experienced cognitive deficits, oxidative stress and neuronal injury in the hippocampus of the brain. We studied the effect of Tualang honey on learning and memory using the Morris water maze (MWM) in rats. Rats were randomly divided into four groups (n=10); Sham control, untreated 2VO (2VO), honey treated 2VO (2VO+H) and honey treated group (H). Each group was again divided into two subgroups (n=5): one for long term memory assessment and another for short term memory and relearning tasks. After 10 weeks of treatment, all rat groups were tested for cognitive assessment by MWM (Morris water maze). 2VO+H rats had better spatial learning and memory performance than untreated 2VO rats in MWM tasks (p<0.05). However, there was no significant difference between Sham rats and H group rats (p>0.05). This study shows that Malaysian Tualang honey might have therapeutic potential for the treatment of chronic cerebral hypoperfusion related neurodegenerative disorders such as Alzheimer’s disease (AD) in which cognitive impairment is profound. Open Access Text ( OAT) 2016-06-25 Article PeerReviewed application/pdf en http://irep.iium.edu.my/52926/1/Anil%20-%20JTS%202016.pdf Saxena, Anil Kumar and Phyu, Hnin Pwint and Al-Ani, Imad Matloub Dally and Syed Ahmad, Pakeer Oothuman (2016) Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration. Journal of Translational Science (JTS), 2 (5). pp. 264-271. ISSN 2059-268X https://oatext.com/pdf/JTS-2-150.pdf DOI: 10.15761/JTS.1000150
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RM Therapeutics. Pharmacology
spellingShingle	R Medicine (General) RM Therapeutics. Pharmacology Saxena, Anil Kumar Phyu, Hnin Pwint Al-Ani, Imad Matloub Dally Syed Ahmad, Pakeer Oothuman Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration
description	Honey has shown potential therapeutic properties in traditional medicine. This study investigated the cognition enhancing potential of Tualang honey in chronic cerebral hypoperfusion- induced neurodegeneration by permanent bilateral common carotid arteries ligation (2 vessels occlusion- 2VO) in rats. Previous studies have shown that rats subjected to 2VO (2 vessel occlusion) experienced cognitive deficits, oxidative stress and neuronal injury in the hippocampus of the brain. We studied the effect of Tualang honey on learning and memory using the Morris water maze (MWM) in rats. Rats were randomly divided into four groups (n=10); Sham control, untreated 2VO (2VO), honey treated 2VO (2VO+H) and honey treated group (H). Each group was again divided into two subgroups (n=5): one for long term memory assessment and another for short term memory and relearning tasks. After 10 weeks of treatment, all rat groups were tested for cognitive assessment by MWM (Morris water maze). 2VO+H rats had better spatial learning and memory performance than untreated 2VO rats in MWM tasks (p<0.05). However, there was no significant difference between Sham rats and H group rats (p>0.05). This study shows that Malaysian Tualang honey might have therapeutic potential for the treatment of chronic cerebral hypoperfusion related neurodegenerative disorders such as Alzheimer’s disease (AD) in which cognitive impairment is profound.
format	Article
author	Saxena, Anil Kumar Phyu, Hnin Pwint Al-Ani, Imad Matloub Dally Syed Ahmad, Pakeer Oothuman
author_facet	Saxena, Anil Kumar Phyu, Hnin Pwint Al-Ani, Imad Matloub Dally Syed Ahmad, Pakeer Oothuman
author_sort	Saxena, Anil Kumar
title	Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration
title_short	Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration
title_full	Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration
title_fullStr	Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration
title_full_unstemmed	Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration
title_sort	improved spatial learning and memory performance following tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration
publisher	Open Access Text ( OAT)
publishDate	2016
url	http://irep.iium.edu.my/52926/ http://irep.iium.edu.my/52926/ http://irep.iium.edu.my/52926/ http://irep.iium.edu.my/52926/1/Anil%20-%20JTS%202016.pdf
first_indexed	2023-09-18T21:14:56Z
last_indexed	2023-09-18T21:14:56Z
_version_	1777411499717820416

Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration

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