The effects of transdermal testosterone and oestrogen therapy on dry eye in postmenopausal women: a randomised, placebo-controlled, pilot study

Aims Sex hormones could provide a future treatment avenue for dry eye post menopause. However, there are few well-controlled studies. This study investigates the impact of testosterone and oestrogen on dry eye symptoms and signs in postmenopausal women. Methods A randomised double-blind placebocont...

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Main Authors:	Golebiowski B, Blanka, Badarudin, Noor Ezailina, Eden, John, Gerrand, Leanne, Robinson, Jennifer, Liu, Jinzhu, Hampel, Ulrike, You, Jingjing, Stapleton, Fiona
Format:	Article
Language:	English
Published:	BMJ 2016
Subjects:	RE Ophthalmology
Online Access:	http://irep.iium.edu.my/52946/ http://irep.iium.edu.my/52946/ http://irep.iium.edu.my/52946/ http://irep.iium.edu.my/52946/1/Br%20J%20Ophthalmol-2016-Ezai.pdf

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recordtype	eprints
spelling	iium-529462016-12-03T04:57:49Z http://irep.iium.edu.my/52946/ The effects of transdermal testosterone and oestrogen therapy on dry eye in postmenopausal women: a randomised, placebo-controlled, pilot study Golebiowski B, Blanka Badarudin, Noor Ezailina Eden, John Gerrand, Leanne Robinson, Jennifer Liu, Jinzhu Hampel, Ulrike You, Jingjing Stapleton, Fiona RE Ophthalmology Aims Sex hormones could provide a future treatment avenue for dry eye post menopause. However, there are few well-controlled studies. This study investigates the impact of testosterone and oestrogen on dry eye symptoms and signs in postmenopausal women. Methods A randomised double-blind placebocontrolled pilot study was conducted involving 40 women with dry eye (age 63.9±5.1 years, 13.2 ±6.3 years post menopause). Ten women were assigned to each of four treatment groups: transdermal testosterone, oestradiol, testosterone/oestradiol combination and placebo. Assessment at baseline and after 8 weeks: ocular symptoms, tear osmolarity, tear stability, tear secretion, meibomian gland assessment, corneal and conjunctival sensitivity, serum concentrations of 17β-oestradiol, 3-α-androstanediol-glucuronide and dehydroepiandrosterone sulfate. Differences from placebo were examined using one-way analysis of variance and Dunnett’s t-test. Within-group analyses included paired t-tests and Spearman correlation. Results Dryness intensity after 8 weeks was significantly worse in the oestrogen group compared with placebo (p=0.04). No significant changes in other symptoms, tear function, meibomian gland function, lid morphology, corneal or conjunctival sensitivity were observed in any of the groups when compared with the change in placebo after 8 weeks. Within-group analyses showed increased tear secretion in the testosterone/ oestradiol combination group ( p=0.03) and a strong association between increased serum androgen and improved tear stability in the testosterone group (ρ=0.83,p=0.01). Conclusions Oestrogen supplementation may worsen ocular symptoms in postmenopausal women with dry eye, whereas no impact of testosterone therapy on symptoms was apparent. The positive effects of oestrogen and testosterone on tear function require confirmation in a larger study, with sample size calculated from the data generated herein. Placebo control is essential in studies of dry eye therapies. BMJ 2016-11-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/52946/1/Br%20J%20Ophthalmol-2016-Ezai.pdf Golebiowski B, Blanka and Badarudin, Noor Ezailina and Eden, John and Gerrand, Leanne and Robinson, Jennifer and Liu, Jinzhu and Hampel, Ulrike and You, Jingjing and Stapleton, Fiona (2016) The effects of transdermal testosterone and oestrogen therapy on dry eye in postmenopausal women: a randomised, placebo-controlled, pilot study. British Journal of Ophthalmology. E-ISSN 1468-2079 (In Press) http://bjo.bmj.com/content/early/2016/11/03/bjophthalmol-2016-309498.abstract :10.1136/bjophthalmol-2016-309498
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RE Ophthalmology
spellingShingle	RE Ophthalmology Golebiowski B, Blanka Badarudin, Noor Ezailina Eden, John Gerrand, Leanne Robinson, Jennifer Liu, Jinzhu Hampel, Ulrike You, Jingjing Stapleton, Fiona The effects of transdermal testosterone and oestrogen therapy on dry eye in postmenopausal women: a randomised, placebo-controlled, pilot study
description	Aims Sex hormones could provide a future treatment avenue for dry eye post menopause. However, there are few well-controlled studies. This study investigates the impact of testosterone and oestrogen on dry eye symptoms and signs in postmenopausal women. Methods A randomised double-blind placebocontrolled pilot study was conducted involving 40 women with dry eye (age 63.9±5.1 years, 13.2 ±6.3 years post menopause). Ten women were assigned to each of four treatment groups: transdermal testosterone, oestradiol, testosterone/oestradiol combination and placebo. Assessment at baseline and after 8 weeks: ocular symptoms, tear osmolarity, tear stability, tear secretion, meibomian gland assessment, corneal and conjunctival sensitivity, serum concentrations of 17β-oestradiol, 3-α-androstanediol-glucuronide and dehydroepiandrosterone sulfate. Differences from placebo were examined using one-way analysis of variance and Dunnett’s t-test. Within-group analyses included paired t-tests and Spearman correlation. Results Dryness intensity after 8 weeks was significantly worse in the oestrogen group compared with placebo (p=0.04). No significant changes in other symptoms, tear function, meibomian gland function, lid morphology, corneal or conjunctival sensitivity were observed in any of the groups when compared with the change in placebo after 8 weeks. Within-group analyses showed increased tear secretion in the testosterone/ oestradiol combination group ( p=0.03) and a strong association between increased serum androgen and improved tear stability in the testosterone group (ρ=0.83,p=0.01). Conclusions Oestrogen supplementation may worsen ocular symptoms in postmenopausal women with dry eye, whereas no impact of testosterone therapy on symptoms was apparent. The positive effects of oestrogen and testosterone on tear function require confirmation in a larger study, with sample size calculated from the data generated herein. Placebo control is essential in studies of dry eye therapies.
format	Article
author	Golebiowski B, Blanka Badarudin, Noor Ezailina Eden, John Gerrand, Leanne Robinson, Jennifer Liu, Jinzhu Hampel, Ulrike You, Jingjing Stapleton, Fiona
author_facet	Golebiowski B, Blanka Badarudin, Noor Ezailina Eden, John Gerrand, Leanne Robinson, Jennifer Liu, Jinzhu Hampel, Ulrike You, Jingjing Stapleton, Fiona
author_sort	Golebiowski B, Blanka
title	The effects of transdermal testosterone and oestrogen therapy on dry eye in postmenopausal women: a randomised, placebo-controlled, pilot study
title_short	The effects of transdermal testosterone and oestrogen therapy on dry eye in postmenopausal women: a randomised, placebo-controlled, pilot study
title_full	The effects of transdermal testosterone and oestrogen therapy on dry eye in postmenopausal women: a randomised, placebo-controlled, pilot study
title_fullStr	The effects of transdermal testosterone and oestrogen therapy on dry eye in postmenopausal women: a randomised, placebo-controlled, pilot study
title_full_unstemmed	The effects of transdermal testosterone and oestrogen therapy on dry eye in postmenopausal women: a randomised, placebo-controlled, pilot study
title_sort	effects of transdermal testosterone and oestrogen therapy on dry eye in postmenopausal women: a randomised, placebo-controlled, pilot study
publisher	BMJ
publishDate	2016
url	http://irep.iium.edu.my/52946/ http://irep.iium.edu.my/52946/ http://irep.iium.edu.my/52946/ http://irep.iium.edu.my/52946/1/Br%20J%20Ophthalmol-2016-Ezai.pdf
first_indexed	2023-09-18T21:14:59Z
last_indexed	2023-09-18T21:14:59Z
_version_	1777411501899907072

The effects of transdermal testosterone and oestrogen therapy on dry eye in postmenopausal women: a randomised, placebo-controlled, pilot study

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