Antidepressant, analgesic activity and SAR studies of substituted benzimidazoles

Purpose. Benzimidazole class of compound is found to have diverse biological properties. From the literature study, it is observed that depression is a severe mental disease affecting a huge population and pain is affecting about 20% of world population. In continuation of our previous research work...

Full description

Bibliographic Details
Main Authors:	Siddiqui, Nadeem, Alam, Md Shamsher, Sahu, Meeta, Yar, M. Shahar, Alam, Ozair, Siddiqui, Mohammad Jamshed
Format:	Article
Language:	English
Published:	Asian Pharma Press 2016
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/53210/ http://irep.iium.edu.my/53210/ http://irep.iium.edu.my/53210/ http://irep.iium.edu.my/53210/1/Asian%20J.%20Pharm.%20Res.%202016%3B%20Vol.%206-%20Issue%203.pdf

id	iium-53210
recordtype	eprints
spelling	iium-532102018-05-05T05:21:26Z http://irep.iium.edu.my/53210/ Antidepressant, analgesic activity and SAR studies of substituted benzimidazoles Siddiqui, Nadeem Alam, Md Shamsher Sahu, Meeta Yar, M. Shahar Alam, Ozair Siddiqui, Mohammad Jamshed QD Chemistry Purpose. Benzimidazole class of compound is found to have diverse biological properties. From the literature study, it is observed that depression is a severe mental disease affecting a huge population and pain is affecting about 20% of world population. In continuation of our previous research work, we selected benzimidazole pharmacophore to further explore its pharmacological activities. Methods. Forced swim test and Thermal stimulus test were used to assess the antidepressant and analgesic activity of synthesized benzimidazole analogs. Results. The antidepressant activity results showed that compound 3j was found most potent having Mean ± SEM value 21.6 ± 0.8 for treated group. Furthermore, in the analgesic test, 3b, 3j, and 3o showed Mean ± SEM values; 1.8 ± 0.10, 2.3 ± 0.10 and 2.2 ± 0.10, respectively. The study results suggested that these compounds could be explored further for the development of better antidepressant and analgesic agents. Conclusion. From the present study, it may be concluded that these active benzimidazole derivatives have been found to possess potential antidepressant and analgesic activity Asian Pharma Press 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/53210/1/Asian%20J.%20Pharm.%20Res.%202016%3B%20Vol.%206-%20Issue%203.pdf Siddiqui, Nadeem and Alam, Md Shamsher and Sahu, Meeta and Yar, M. Shahar and Alam, Ozair and Siddiqui, Mohammad Jamshed (2016) Antidepressant, analgesic activity and SAR studies of substituted benzimidazoles. Asian Journal of Pharmaceutical Research, 6 (3). pp. 170-174. ISSN 2231-5683 E-ISSN 2231-5691 http://www.asianjpr.com 10.5958/2231-5691.2016.00024.1
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Siddiqui, Nadeem Alam, Md Shamsher Sahu, Meeta Yar, M. Shahar Alam, Ozair Siddiqui, Mohammad Jamshed Antidepressant, analgesic activity and SAR studies of substituted benzimidazoles
description	Purpose. Benzimidazole class of compound is found to have diverse biological properties. From the literature study, it is observed that depression is a severe mental disease affecting a huge population and pain is affecting about 20% of world population. In continuation of our previous research work, we selected benzimidazole pharmacophore to further explore its pharmacological activities. Methods. Forced swim test and Thermal stimulus test were used to assess the antidepressant and analgesic activity of synthesized benzimidazole analogs. Results. The antidepressant activity results showed that compound 3j was found most potent having Mean ± SEM value 21.6 ± 0.8 for treated group. Furthermore, in the analgesic test, 3b, 3j, and 3o showed Mean ± SEM values; 1.8 ± 0.10, 2.3 ± 0.10 and 2.2 ± 0.10, respectively. The study results suggested that these compounds could be explored further for the development of better antidepressant and analgesic agents. Conclusion. From the present study, it may be concluded that these active benzimidazole derivatives have been found to possess potential antidepressant and analgesic activity
format	Article
author	Siddiqui, Nadeem Alam, Md Shamsher Sahu, Meeta Yar, M. Shahar Alam, Ozair Siddiqui, Mohammad Jamshed
author_facet	Siddiqui, Nadeem Alam, Md Shamsher Sahu, Meeta Yar, M. Shahar Alam, Ozair Siddiqui, Mohammad Jamshed
author_sort	Siddiqui, Nadeem
title	Antidepressant, analgesic activity and SAR studies of substituted benzimidazoles
title_short	Antidepressant, analgesic activity and SAR studies of substituted benzimidazoles
title_full	Antidepressant, analgesic activity and SAR studies of substituted benzimidazoles
title_fullStr	Antidepressant, analgesic activity and SAR studies of substituted benzimidazoles
title_full_unstemmed	Antidepressant, analgesic activity and SAR studies of substituted benzimidazoles
title_sort	antidepressant, analgesic activity and sar studies of substituted benzimidazoles
publisher	Asian Pharma Press
publishDate	2016
url	http://irep.iium.edu.my/53210/ http://irep.iium.edu.my/53210/ http://irep.iium.edu.my/53210/ http://irep.iium.edu.my/53210/1/Asian%20J.%20Pharm.%20Res.%202016%3B%20Vol.%206-%20Issue%203.pdf
first_indexed	2023-09-18T21:15:19Z
last_indexed	2023-09-18T21:15:19Z
_version_	1777411523789979648

Antidepressant, analgesic activity and SAR studies of substituted benzimidazoles

Similar Items