Preclinical evidence of Malay traditional herbal supplement for diabetes

In this report, one herbal folk recipe traditional claim for diabetes treatment, jamu KM is subjected to scientific studies. The exposure of traditional diabetes decoction, KM extract to 3T3-L1 at 1 mg mL-1 shows significant increase in glucose uptake with no LD50 value. 150 μg mL-1 methanolic ext...

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Main Authors:	Abdul Majid, Fadzilah Adibah, Teh, L. C, Sayid Abdullah, S.H.A, Ahmad, Rabiatul Adawiyah, Bakhtiar, M. Taher, Abdul Wahid, Mohd Effendy
Other Authors:	Patil, S
Format:	Conference or Workshop Item
Language:	English English
Published:	http://www.ishs.org/ishs-article/1125_32 2016
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/53348/ http://irep.iium.edu.my/53348/ http://irep.iium.edu.my/53348/1/53348_Preclinical%20evidence%20of%20Malay%20traditional%20herbal.pdf http://irep.iium.edu.my/53348/7/53348_Preclinical%20evidence%20of%20Malay%20traditional%20herbal_SCOPUS.pdf

id	iium-53348
recordtype	eprints
spelling	iium-533482017-10-11T02:04:23Z http://irep.iium.edu.my/53348/ Preclinical evidence of Malay traditional herbal supplement for diabetes Abdul Majid, Fadzilah Adibah Teh, L. C Sayid Abdullah, S.H.A Ahmad, Rabiatul Adawiyah Bakhtiar, M. Taher Abdul Wahid, Mohd Effendy RS Pharmacy and materia medica In this report, one herbal folk recipe traditional claim for diabetes treatment, jamu KM is subjected to scientific studies. The exposure of traditional diabetes decoction, KM extract to 3T3-L1 at 1 mg mL-1 shows significant increase in glucose uptake with no LD50 value. 150 μg mL-1 methanolic extract of Jamu KM yield intense lipid droplet accumulation in non-insulin induced adipocytes 3T3-L1. Further investigation through in vivo study of KM extract using diabetic Spraque Dawley rats indicates reduction in blood glucose at the concentration of 0.05 g kg-1 body weight (bwt). A similar response was observed with the treatment using glibenclamide at 0.006 g kg-1 bwt. Histopathological data show increase in the relative organ weight (g 100 g-1 bwt) of liver and kidney of all diabetic rats as compared to normal group while pancreas was not affected. However, glibenclamide treated group shows 14 and 15% larger liver and kidney, respectively, than the other diabetic groups and jamu KM treated. This finding is a promising approach in validation of herbal medication from the past wisdom through modern techniques. http://www.ishs.org/ishs-article/1125_32 Patil, S Gafner, S Cracker, L Mentreddy, S.R 2016 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/53348/1/53348_Preclinical%20evidence%20of%20Malay%20traditional%20herbal.pdf application/pdf en http://irep.iium.edu.my/53348/7/53348_Preclinical%20evidence%20of%20Malay%20traditional%20herbal_SCOPUS.pdf Abdul Majid, Fadzilah Adibah and Teh, L. C and Sayid Abdullah, S.H.A and Ahmad, Rabiatul Adawiyah and Bakhtiar, M. Taher and Abdul Wahid, Mohd Effendy (2016) Preclinical evidence of Malay traditional herbal supplement for diabetes. In: V World Congress on Medicinal and Aromatic Plants (WOCMAP) and International Symposium on Plants, as Factories of Natural Substances, Edible and Essential Oils, 17th-22th Aug. 2014, Brisbane, Australia. http://www.actahort.org/books/1125/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Abdul Majid, Fadzilah Adibah Teh, L. C Sayid Abdullah, S.H.A Ahmad, Rabiatul Adawiyah Bakhtiar, M. Taher Abdul Wahid, Mohd Effendy Preclinical evidence of Malay traditional herbal supplement for diabetes
description	In this report, one herbal folk recipe traditional claim for diabetes treatment, jamu KM is subjected to scientific studies. The exposure of traditional diabetes decoction, KM extract to 3T3-L1 at 1 mg mL-1 shows significant increase in glucose uptake with no LD50 value. 150 μg mL-1 methanolic extract of Jamu KM yield intense lipid droplet accumulation in non-insulin induced adipocytes 3T3-L1. Further investigation through in vivo study of KM extract using diabetic Spraque Dawley rats indicates reduction in blood glucose at the concentration of 0.05 g kg-1 body weight (bwt). A similar response was observed with the treatment using glibenclamide at 0.006 g kg-1 bwt. Histopathological data show increase in the relative organ weight (g 100 g-1 bwt) of liver and kidney of all diabetic rats as compared to normal group while pancreas was not affected. However, glibenclamide treated group shows 14 and 15% larger liver and kidney, respectively, than the other diabetic groups and jamu KM treated. This finding is a promising approach in validation of herbal medication from the past wisdom through modern techniques.
author2	Patil, S
author_facet	Patil, S Abdul Majid, Fadzilah Adibah Teh, L. C Sayid Abdullah, S.H.A Ahmad, Rabiatul Adawiyah Bakhtiar, M. Taher Abdul Wahid, Mohd Effendy
format	Conference or Workshop Item
author	Abdul Majid, Fadzilah Adibah Teh, L. C Sayid Abdullah, S.H.A Ahmad, Rabiatul Adawiyah Bakhtiar, M. Taher Abdul Wahid, Mohd Effendy
author_sort	Abdul Majid, Fadzilah Adibah
title	Preclinical evidence of Malay traditional herbal supplement for diabetes
title_short	Preclinical evidence of Malay traditional herbal supplement for diabetes
title_full	Preclinical evidence of Malay traditional herbal supplement for diabetes
title_fullStr	Preclinical evidence of Malay traditional herbal supplement for diabetes
title_full_unstemmed	Preclinical evidence of Malay traditional herbal supplement for diabetes
title_sort	preclinical evidence of malay traditional herbal supplement for diabetes
publisher	http://www.ishs.org/ishs-article/1125_32
publishDate	2016
url	http://irep.iium.edu.my/53348/ http://irep.iium.edu.my/53348/ http://irep.iium.edu.my/53348/1/53348_Preclinical%20evidence%20of%20Malay%20traditional%20herbal.pdf http://irep.iium.edu.my/53348/7/53348_Preclinical%20evidence%20of%20Malay%20traditional%20herbal_SCOPUS.pdf
first_indexed	2023-09-18T21:15:30Z
last_indexed	2023-09-18T21:15:30Z
_version_	1777411534581923840

Preclinical evidence of Malay traditional herbal supplement for diabetes

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