Prescribing patterns of benzodiazepine in Malaysia from 2014 to 2016

Background: Although benzodiazepines (BZDs) are often prescribed to treat wide range of psychiatric and neurological conditions, they are also associated with various harms and risks, as well as tendency of inappropriate prescribing. To date, the prescribing patterns of BZDs at outpatient terti...

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Main Authors:	Ab Rahman, Norny Syafinaz, Pakururazi, Fatin Azzyati, Zin, Che Suraya, Abdul Halim, Helina
Format:	Article
Language:	English English
Published:	Wiley 2018
Subjects:	RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/53465/ http://irep.iium.edu.my/53465/ http://irep.iium.edu.my/53465/1/53465_Prescribing%20patterns%20of%20benzodiazepine.pdf http://irep.iium.edu.my/53465/2/53465_Prescribing%20patterns%20of%20benzodiazepine_WOS.pdf

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spelling	iium-534652019-04-25T07:47:10Z http://irep.iium.edu.my/53465/ Prescribing patterns of benzodiazepine in Malaysia from 2014 to 2016 Ab Rahman, Norny Syafinaz Pakururazi, Fatin Azzyati Zin, Che Suraya Abdul Halim, Helina RM Therapeutics. Pharmacology Background: Although benzodiazepines (BZDs) are often prescribed to treat wide range of psychiatric and neurological conditions, they are also associated with various harms and risks, as well as tendency of inappropriate prescribing. To date, the prescribing patterns of BZDs at outpatient tertiary hospital in Malaysia are still scarce. Objectives: To examine the patterns of BZDs prescribing at outpatient tertiary hospital in Malaysia. Methods: A cross‐sectional retrospective study was conducted from January 2014 to December 2016 using the prescriptions received by the outpatient pharmacy of tertiary hospital. Prescriptions with any seven types of BZDs (alprazolam, bromazepam, clobazam, diazepam, clonazepam, loraxepam, and midazolam) were identified and included in this study. Information on patients' age and gender, prescription date, drug name, dosage, frequency, duration, quantity supplied, and prescriber's name were extracted from the prescriptions. Only prescrip- tions for patients' age of 18 and above were included in this study. Total number of prescriptions with BZDs, total number of patients received BZDs, and total number of each type of BZDs were measured yearly and over 3 years. Data were analyzed descriptively using Stata v13. Results: A total of 5711 BZDs prescriptions were issued (n = 1959, n = 2051, and n = 1701 for year 2014, 2015, and 2016, respectively) from January 2014 to December 2016. BZDs were prescribed for 1947 patients (n = 895 in year 2014, n = 934 in 2015, and n = 782 in 2016). Alprazolam (39.7%, n = 3542) was the most frequently pre- scribed followed by lorazepam (21.1%, n = 1880), diazepam (20.7%, n = 1851), clonazepam (17.1%, n = 1530), and less than 1% to other BZDs. Sixty percent (n = 5422) of patient were prescribed with short‐acting BZDs, 21.6% (n = 1928) intermediate‐acting BZDs and 17.1% (n = 1530) long acting BZDs. Majority (90.7%, n = 5015) of BZDs prescription were for psychiatric disorders, in which, higher per- centage (82.3%) of BZDs were prescribed as anxiolytics followed by 17.1% as hypnotics. Among all BZDs, alprazolam, and lorazepam showed decreasing pattern over 3 years period. Conclusions: Short‐acting BZDs (alprazolam and lorazepam) were highly prescribed at the outpatient tertiary hospital in Malaysia. The main indication of the BZDs was as anti‐anxiety. However, data avail- able were from the prescriptions only. Thus, further research is required to examine the use of BZDs at patient‐level. Wiley 2018-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/53465/1/53465_Prescribing%20patterns%20of%20benzodiazepine.pdf application/pdf en http://irep.iium.edu.my/53465/2/53465_Prescribing%20patterns%20of%20benzodiazepine_WOS.pdf Ab Rahman, Norny Syafinaz and Pakururazi, Fatin Azzyati and Zin, Che Suraya and Abdul Halim, Helina (2018) Prescribing patterns of benzodiazepine in Malaysia from 2014 to 2016. Pharmacoepidemiology And Drug Safety, 27 (Supp. 2). p. 317. ISSN 1053-8569 E-ISSN 1099-1557 https://onlinelibrary.wiley.com/doi/epdf/10.1002/pds.4629
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RM Therapeutics. Pharmacology
spellingShingle	RM Therapeutics. Pharmacology Ab Rahman, Norny Syafinaz Pakururazi, Fatin Azzyati Zin, Che Suraya Abdul Halim, Helina Prescribing patterns of benzodiazepine in Malaysia from 2014 to 2016
description	Background: Although benzodiazepines (BZDs) are often prescribed to treat wide range of psychiatric and neurological conditions, they are also associated with various harms and risks, as well as tendency of inappropriate prescribing. To date, the prescribing patterns of BZDs at outpatient tertiary hospital in Malaysia are still scarce. Objectives: To examine the patterns of BZDs prescribing at outpatient tertiary hospital in Malaysia. Methods: A cross‐sectional retrospective study was conducted from January 2014 to December 2016 using the prescriptions received by the outpatient pharmacy of tertiary hospital. Prescriptions with any seven types of BZDs (alprazolam, bromazepam, clobazam, diazepam, clonazepam, loraxepam, and midazolam) were identified and included in this study. Information on patients' age and gender, prescription date, drug name, dosage, frequency, duration, quantity supplied, and prescriber's name were extracted from the prescriptions. Only prescrip- tions for patients' age of 18 and above were included in this study. Total number of prescriptions with BZDs, total number of patients received BZDs, and total number of each type of BZDs were measured yearly and over 3 years. Data were analyzed descriptively using Stata v13. Results: A total of 5711 BZDs prescriptions were issued (n = 1959, n = 2051, and n = 1701 for year 2014, 2015, and 2016, respectively) from January 2014 to December 2016. BZDs were prescribed for 1947 patients (n = 895 in year 2014, n = 934 in 2015, and n = 782 in 2016). Alprazolam (39.7%, n = 3542) was the most frequently pre- scribed followed by lorazepam (21.1%, n = 1880), diazepam (20.7%, n = 1851), clonazepam (17.1%, n = 1530), and less than 1% to other BZDs. Sixty percent (n = 5422) of patient were prescribed with short‐acting BZDs, 21.6% (n = 1928) intermediate‐acting BZDs and 17.1% (n = 1530) long acting BZDs. Majority (90.7%, n = 5015) of BZDs prescription were for psychiatric disorders, in which, higher per- centage (82.3%) of BZDs were prescribed as anxiolytics followed by 17.1% as hypnotics. Among all BZDs, alprazolam, and lorazepam showed decreasing pattern over 3 years period. Conclusions: Short‐acting BZDs (alprazolam and lorazepam) were highly prescribed at the outpatient tertiary hospital in Malaysia. The main indication of the BZDs was as anti‐anxiety. However, data avail- able were from the prescriptions only. Thus, further research is required to examine the use of BZDs at patient‐level.
format	Article
author	Ab Rahman, Norny Syafinaz Pakururazi, Fatin Azzyati Zin, Che Suraya Abdul Halim, Helina
author_facet	Ab Rahman, Norny Syafinaz Pakururazi, Fatin Azzyati Zin, Che Suraya Abdul Halim, Helina
author_sort	Ab Rahman, Norny Syafinaz
title	Prescribing patterns of benzodiazepine in Malaysia from 2014 to 2016
title_short	Prescribing patterns of benzodiazepine in Malaysia from 2014 to 2016
title_full	Prescribing patterns of benzodiazepine in Malaysia from 2014 to 2016
title_fullStr	Prescribing patterns of benzodiazepine in Malaysia from 2014 to 2016
title_full_unstemmed	Prescribing patterns of benzodiazepine in Malaysia from 2014 to 2016
title_sort	prescribing patterns of benzodiazepine in malaysia from 2014 to 2016
publisher	Wiley
publishDate	2018
url	http://irep.iium.edu.my/53465/ http://irep.iium.edu.my/53465/ http://irep.iium.edu.my/53465/1/53465_Prescribing%20patterns%20of%20benzodiazepine.pdf http://irep.iium.edu.my/53465/2/53465_Prescribing%20patterns%20of%20benzodiazepine_WOS.pdf
first_indexed	2023-09-18T21:15:38Z
last_indexed	2023-09-18T21:15:38Z
_version_	1777411542878257152

Prescribing patterns of benzodiazepine in Malaysia from 2014 to 2016

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