Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract

Herbal medicine has been proven to be an effective therapy offering a variety of benefits, such as moderate reduction in hypoglycemia, in the treatment and prevention of obesity and diabetes. Phyllanthus niruri has been used as a treatment for diabetes mellitus. Herein, the induction of type 2 diabe...

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Main Authors:	Mediani, Ahmed, Abas, Faridah, Maulidiani, H., Khatib, Alfi, Tan, Chin Ping, Ismail, Intan Safinar, Shaari, Khozirah, Ismail, Amin, Lajis, Nordin H.
Format:	Article
Language:	English
Published:	2016
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/53494/ http://irep.iium.edu.my/53494/ http://irep.iium.edu.my/53494/1/mediani2016.pdf

id	iium-53494
recordtype	eprints
spelling	iium-534942017-01-04T04:15:17Z http://irep.iium.edu.my/53494/ Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract Mediani, Ahmed Abas, Faridah Maulidiani, H. Khatib, Alfi Tan, Chin Ping Ismail, Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, Nordin H. Q Science (General) Herbal medicine has been proven to be an effective therapy offering a variety of benefits, such as moderate reduction in hypoglycemia, in the treatment and prevention of obesity and diabetes. Phyllanthus niruri has been used as a treatment for diabetes mellitus. Herein, the induction of type 2 diabetes in Sprague–Dawley rats was achieved by a low dose of streptozotocin (STZ) (25 mg/kg bw). Here, we evaluated the in vivo antidiabetic properties of two concentrations (250 and 500 mg/kg bw) of P. niruri via metabolomics approach. The administration of 500 mg/kg bw of P. niruri extract caused the metabolic disorders of obese diabetic rats to be improved towards the normal state. The extract also clearly decreased the serum glucose level and improved the lipid profile in obese diabetic rats. The results of this study may contribute towards better understanding the molecular mechanism of this medicinal plant in managing diabetes mellitus. 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/53494/1/mediani2016.pdf Mediani, Ahmed and Abas, Faridah and Maulidiani, H. and Khatib, Alfi and Tan, Chin Ping and Ismail, Intan Safinar and Shaari, Khozirah and Ismail, Amin and Lajis, Nordin H. (2016) Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract. Journal of Pharmaceutical and Biomedical Analysis, 128. pp. 302-312. ISSN 0731-7085 10.1016/j.jpba.2016.06.003
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Mediani, Ahmed Abas, Faridah Maulidiani, H. Khatib, Alfi Tan, Chin Ping Ismail, Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, Nordin H. Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract
description	Herbal medicine has been proven to be an effective therapy offering a variety of benefits, such as moderate reduction in hypoglycemia, in the treatment and prevention of obesity and diabetes. Phyllanthus niruri has been used as a treatment for diabetes mellitus. Herein, the induction of type 2 diabetes in Sprague–Dawley rats was achieved by a low dose of streptozotocin (STZ) (25 mg/kg bw). Here, we evaluated the in vivo antidiabetic properties of two concentrations (250 and 500 mg/kg bw) of P. niruri via metabolomics approach. The administration of 500 mg/kg bw of P. niruri extract caused the metabolic disorders of obese diabetic rats to be improved towards the normal state. The extract also clearly decreased the serum glucose level and improved the lipid profile in obese diabetic rats. The results of this study may contribute towards better understanding the molecular mechanism of this medicinal plant in managing diabetes mellitus.
format	Article
author	Mediani, Ahmed Abas, Faridah Maulidiani, H. Khatib, Alfi Tan, Chin Ping Ismail, Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, Nordin H.
author_facet	Mediani, Ahmed Abas, Faridah Maulidiani, H. Khatib, Alfi Tan, Chin Ping Ismail, Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, Nordin H.
author_sort	Mediani, Ahmed
title	Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract
title_short	Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract
title_full	Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract
title_fullStr	Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract
title_full_unstemmed	Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract
title_sort	metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with phyllanthus niruri extract
publishDate	2016
url	http://irep.iium.edu.my/53494/ http://irep.iium.edu.my/53494/ http://irep.iium.edu.my/53494/1/mediani2016.pdf
first_indexed	2023-09-18T21:15:40Z
last_indexed	2023-09-18T21:15:40Z
_version_	1777411545206095872

Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract

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