STRETCHABLE lab-on-chip device with impedance spectroscopy capability for mammalian cell studies

This paper presents the fabrication and testing of electric cellsubstrate impedance spectroscopy (ECIS) electrodes on a stretchable membrane. This is the first time when ECIS electrodes were fabricated on a stretchable substrate and ECIS measurements on mammalian cells exposed to cyclic strain of 10...

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Main Authors:	Xudong, Zhang, Nordin, Anis Nurashikin, Li, Fang, Voiculescu, Ioana R.
Format:	Conference or Workshop Item
Language:	English English English
Published:	American Society of Mechanical Engineers (ASME) 2016
Subjects:	TJ241 Machine construction (General)
Online Access:	http://irep.iium.edu.my/53868/ http://irep.iium.edu.my/53868/ http://irep.iium.edu.my/53868/ http://irep.iium.edu.my/53868/13/53868_STRETCHABLE%20lab-on-chip%20device_conf.%20article_complete.pdf http://irep.iium.edu.my/53868/2/53868_STRETCHABLE%20lab-on-chip%20device_SCOPUS.pdf http://irep.iium.edu.my/53868/14/53868_STRETCHABLE%20lab-on-chip%20device_wos.pdf

id	iium-53868
recordtype	eprints
spelling	iium-538682019-08-25T08:30:08Z http://irep.iium.edu.my/53868/ STRETCHABLE lab-on-chip device with impedance spectroscopy capability for mammalian cell studies Xudong, Zhang Nordin, Anis Nurashikin Li, Fang Voiculescu, Ioana R. TJ241 Machine construction (General) This paper presents the fabrication and testing of electric cellsubstrate impedance spectroscopy (ECIS) electrodes on a stretchable membrane. This is the first time when ECIS electrodes were fabricated on a stretchable substrate and ECIS measurements on mammalian cells exposed to cyclic strain of 10% were successfully demonstrated. A chemical was used to form strong chemical bond between gold electrodes of ECIS sensor and polymer membrane, which enable the electrodes keep good conductive ability during cyclic stretch. The stretchable membrane integrated with the ECIS sensor can simulate and replicate the dynamic environment of organism and enable the analysis of the cells activity involved in cells attachment and proliferation in vitro. Bovine aortic endothelial cells (BAEC) were used to evaluate the endothelial function influenced by mechanical stimuli in this research because they undergo in vivo cyclic physiologic elongation produced by the blood circulation in the arteries. Copyright © 2016 by ASME. American Society of Mechanical Engineers (ASME) 2016-11 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/53868/13/53868_STRETCHABLE%20lab-on-chip%20device_conf.%20article_complete.pdf application/pdf en http://irep.iium.edu.my/53868/2/53868_STRETCHABLE%20lab-on-chip%20device_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/53868/14/53868_STRETCHABLE%20lab-on-chip%20device_wos.pdf Xudong, Zhang and Nordin, Anis Nurashikin and Li, Fang and Voiculescu, Ioana R. (2016) STRETCHABLE lab-on-chip device with impedance spectroscopy capability for mammalian cell studies. In: ASME 2016 International Mechanical Engineering Congress and Exposition, IMECE 2016, 11th-17th November 2016, Phoenix, United States. http://proceedings.asmedigitalcollection.asme.org/proceeding.aspx?articleid=2602735 10.1115/IMECE201666156
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	TJ241 Machine construction (General)
spellingShingle	TJ241 Machine construction (General) Xudong, Zhang Nordin, Anis Nurashikin Li, Fang Voiculescu, Ioana R. STRETCHABLE lab-on-chip device with impedance spectroscopy capability for mammalian cell studies
description	This paper presents the fabrication and testing of electric cellsubstrate impedance spectroscopy (ECIS) electrodes on a stretchable membrane. This is the first time when ECIS electrodes were fabricated on a stretchable substrate and ECIS measurements on mammalian cells exposed to cyclic strain of 10% were successfully demonstrated. A chemical was used to form strong chemical bond between gold electrodes of ECIS sensor and polymer membrane, which enable the electrodes keep good conductive ability during cyclic stretch. The stretchable membrane integrated with the ECIS sensor can simulate and replicate the dynamic environment of organism and enable the analysis of the cells activity involved in cells attachment and proliferation in vitro. Bovine aortic endothelial cells (BAEC) were used to evaluate the endothelial function influenced by mechanical stimuli in this research because they undergo in vivo cyclic physiologic elongation produced by the blood circulation in the arteries. Copyright © 2016 by ASME.
format	Conference or Workshop Item
author	Xudong, Zhang Nordin, Anis Nurashikin Li, Fang Voiculescu, Ioana R.
author_facet	Xudong, Zhang Nordin, Anis Nurashikin Li, Fang Voiculescu, Ioana R.
author_sort	Xudong, Zhang
title	STRETCHABLE lab-on-chip device with impedance spectroscopy capability for mammalian cell studies
title_short	STRETCHABLE lab-on-chip device with impedance spectroscopy capability for mammalian cell studies
title_full	STRETCHABLE lab-on-chip device with impedance spectroscopy capability for mammalian cell studies
title_fullStr	STRETCHABLE lab-on-chip device with impedance spectroscopy capability for mammalian cell studies
title_full_unstemmed	STRETCHABLE lab-on-chip device with impedance spectroscopy capability for mammalian cell studies
title_sort	stretchable lab-on-chip device with impedance spectroscopy capability for mammalian cell studies
publisher	American Society of Mechanical Engineers (ASME)
publishDate	2016
url	http://irep.iium.edu.my/53868/ http://irep.iium.edu.my/53868/ http://irep.iium.edu.my/53868/ http://irep.iium.edu.my/53868/13/53868_STRETCHABLE%20lab-on-chip%20device_conf.%20article_complete.pdf http://irep.iium.edu.my/53868/2/53868_STRETCHABLE%20lab-on-chip%20device_SCOPUS.pdf http://irep.iium.edu.my/53868/14/53868_STRETCHABLE%20lab-on-chip%20device_wos.pdf
first_indexed	2023-09-18T21:16:12Z
last_indexed	2023-09-18T21:16:12Z
_version_	1777411578692370432

STRETCHABLE lab-on-chip device with impedance spectroscopy capability for mammalian cell studies

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