Production of polylactic acid nanoparticles encapsulating astaxanthin

Astaxanthin is one of the carotenoid that has high antioxidant characteristics among other carotenoids. Hence it can play an active role in the prevention of cancer and cardiovascular diseases. However, its use as a high value pharmaceutical product is limited by its low water solubility and bioav...

Full description

Bibliographic Details
Main Authors:	Ibrahim Ali, Noorbatcha, Ahmad Zawawi, Ahmad Fandi, Ali, Fathilah, Jaswir, Irwandi
Format:	Conference or Workshop Item
Language:	English English
Published:	2016
Subjects:	TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/53920/ http://irep.iium.edu.my/53920/ http://irep.iium.edu.my/53920/1/ID151%20PLA%20astaxanthin%20NP%20ICBIOE2016.pdf http://irep.iium.edu.my/53920/2/ICBioE2016%20Programme%20Book%20cover%20page%20and%20ID151%20schedule.pdf

id	iium-53920
recordtype	eprints
spelling	iium-539202017-01-11T01:03:17Z http://irep.iium.edu.my/53920/ Production of polylactic acid nanoparticles encapsulating astaxanthin Ibrahim Ali, Noorbatcha Ahmad Zawawi, Ahmad Fandi Ali, Fathilah Jaswir, Irwandi TP248.13 Biotechnology Astaxanthin is one of the carotenoid that has high antioxidant characteristics among other carotenoids. Hence it can play an active role in the prevention of cancer and cardiovascular diseases. However, its use as a high value pharmaceutical product is limited by its low water solubility and bioavailability. Nanoencapsulation of active materials in a biodegradable polymer matrix can be used to alleviate this problem. In addition to increasing the stability of the active compounds inside the matrix, nanoencapsulation can also be used to manipulate the controlled and sustained release of active materials into the target area. Poly-lactic acid (PLA) is a good drug carrier based on its biodegradability and biocompatibility. PLA have been reported as an encapsulated material and delivery vehicle for several active compounds. In this study, PLA along with poly-vinyl alcohol (PVA) was used to encapsulate astaxanthin using single emulsion method. The effect of PLA and PVA concentration on drug loading and drug entrapment was analyzed, and the optimum conditions for high drug loading were found to be 8.71 mg of PLA and 8.26 % of PVA solution. The in-vitro drug release of astaxanthin from the nanoparticles shows an initial burst profile followed by a slow release until 24 hours. 2016-07-26 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/53920/1/ID151%20PLA%20astaxanthin%20NP%20ICBIOE2016.pdf application/pdf en http://irep.iium.edu.my/53920/2/ICBioE2016%20Programme%20Book%20cover%20page%20and%20ID151%20schedule.pdf Ibrahim Ali, Noorbatcha and Ahmad Zawawi, Ahmad Fandi and Ali, Fathilah and Jaswir, Irwandi (2016) Production of polylactic acid nanoparticles encapsulating astaxanthin. In: 4th International Conference on Biotechnology Engineering 2016 (ICBioE 2016), 25th-27th July 2016, Kuala Lumpur. (Unpublished) http://www.iium.edu.my/icbioe/2016/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	TP248.13 Biotechnology
spellingShingle	TP248.13 Biotechnology Ibrahim Ali, Noorbatcha Ahmad Zawawi, Ahmad Fandi Ali, Fathilah Jaswir, Irwandi Production of polylactic acid nanoparticles encapsulating astaxanthin
description	Astaxanthin is one of the carotenoid that has high antioxidant characteristics among other carotenoids. Hence it can play an active role in the prevention of cancer and cardiovascular diseases. However, its use as a high value pharmaceutical product is limited by its low water solubility and bioavailability. Nanoencapsulation of active materials in a biodegradable polymer matrix can be used to alleviate this problem. In addition to increasing the stability of the active compounds inside the matrix, nanoencapsulation can also be used to manipulate the controlled and sustained release of active materials into the target area. Poly-lactic acid (PLA) is a good drug carrier based on its biodegradability and biocompatibility. PLA have been reported as an encapsulated material and delivery vehicle for several active compounds. In this study, PLA along with poly-vinyl alcohol (PVA) was used to encapsulate astaxanthin using single emulsion method. The effect of PLA and PVA concentration on drug loading and drug entrapment was analyzed, and the optimum conditions for high drug loading were found to be 8.71 mg of PLA and 8.26 % of PVA solution. The in-vitro drug release of astaxanthin from the nanoparticles shows an initial burst profile followed by a slow release until 24 hours.
format	Conference or Workshop Item
author	Ibrahim Ali, Noorbatcha Ahmad Zawawi, Ahmad Fandi Ali, Fathilah Jaswir, Irwandi
author_facet	Ibrahim Ali, Noorbatcha Ahmad Zawawi, Ahmad Fandi Ali, Fathilah Jaswir, Irwandi
author_sort	Ibrahim Ali, Noorbatcha
title	Production of polylactic acid nanoparticles encapsulating astaxanthin
title_short	Production of polylactic acid nanoparticles encapsulating astaxanthin
title_full	Production of polylactic acid nanoparticles encapsulating astaxanthin
title_fullStr	Production of polylactic acid nanoparticles encapsulating astaxanthin
title_full_unstemmed	Production of polylactic acid nanoparticles encapsulating astaxanthin
title_sort	production of polylactic acid nanoparticles encapsulating astaxanthin
publishDate	2016
url	http://irep.iium.edu.my/53920/ http://irep.iium.edu.my/53920/ http://irep.iium.edu.my/53920/1/ID151%20PLA%20astaxanthin%20NP%20ICBIOE2016.pdf http://irep.iium.edu.my/53920/2/ICBioE2016%20Programme%20Book%20cover%20page%20and%20ID151%20schedule.pdf
first_indexed	2023-09-18T21:16:16Z
last_indexed	2023-09-18T21:16:16Z
_version_	1777411583603900416

Production of polylactic acid nanoparticles encapsulating astaxanthin

Similar Items