Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger

The extraction of Kaempferia galanga rhizome using steam distillation and supercritical fluid extraction (SFE) was carried out. After fractionation, the major compound of the K. galanga extract, ethyl p-methoxycinnamate (EPMC) was transformed using Aspergillus niger into ethyl p-hydroxycinnamate (EP...

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Main Authors:	Omar, Muhammad Nor, Hasali, Nor Hazwani, Yarmo, Mohd Ambar
Format:	Article
Language:	English English English
Published:	Oriental Scientific Publishing Company 2016
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/54229/ http://irep.iium.edu.my/54229/ http://irep.iium.edu.my/54229/ http://irep.iium.edu.my/54229/1/PROF%20NO%20OJC_Vol32_No5_p_2731-2734-2.pdf http://irep.iium.edu.my/54229/7/54229_Cytotoxicity%20Activity%20of%20Biotransformed%20Ethyl_WOS.pdf http://irep.iium.edu.my/54229/8/54229_Cytotoxicity%20Activity%20of%20Biotransformed%20Ethyl_SCOPUS.pdf

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recordtype	eprints
spelling	iium-542292017-11-21T09:17:00Z http://irep.iium.edu.my/54229/ Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger Omar, Muhammad Nor Hasali, Nor Hazwani Yarmo, Mohd Ambar QD Chemistry The extraction of Kaempferia galanga rhizome using steam distillation and supercritical fluid extraction (SFE) was carried out. After fractionation, the major compound of the K. galanga extract, ethyl p-methoxycinnamate (EPMC) was transformed using Aspergillus niger into ethyl p-hydroxycinnamate (EPHC). The biological anticancer activity of EPMC and its biotransformed product (EPHC) was established by cytotoxicity activity on the human breast cancer (MCF-7) cell line using MTT assay. Ethyl p-hydroxycinnamate (EPHC) was most cytotoxic against MCF-7 at 1000 μg/mL where percentage of cell viability was 9.87 %, while IC50 was 340 μg/mL. EPHC showed slightly higher cytotoxicity activity compared to EPMC. The results of this study show that the biotransformation process was able to produce a metabolite (EPHC) with higher cytotoxicity activity compared to its parent compound (EPMC). Oriental Scientific Publishing Company 2016-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/54229/1/PROF%20NO%20OJC_Vol32_No5_p_2731-2734-2.pdf application/pdf en http://irep.iium.edu.my/54229/7/54229_Cytotoxicity%20Activity%20of%20Biotransformed%20Ethyl_WOS.pdf application/pdf en http://irep.iium.edu.my/54229/8/54229_Cytotoxicity%20Activity%20of%20Biotransformed%20Ethyl_SCOPUS.pdf Omar, Muhammad Nor and Hasali, Nor Hazwani and Yarmo, Mohd Ambar (2016) Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger. Oriental Journal of Chemistry, 32 (5). pp. 2732-2734. ISSN 0970-020X E-ISSN 2231-5039 http://www.orientjchem.org/vol32no5/cytotoxicity-activity-of-biotransformedethyl-p-methoxycinnamate-by-aspergillusniger/ 10.13005/ojc/320547
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	QD Chemistry
spellingShingle	QD Chemistry Omar, Muhammad Nor Hasali, Nor Hazwani Yarmo, Mohd Ambar Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger
description	The extraction of Kaempferia galanga rhizome using steam distillation and supercritical fluid extraction (SFE) was carried out. After fractionation, the major compound of the K. galanga extract, ethyl p-methoxycinnamate (EPMC) was transformed using Aspergillus niger into ethyl p-hydroxycinnamate (EPHC). The biological anticancer activity of EPMC and its biotransformed product (EPHC) was established by cytotoxicity activity on the human breast cancer (MCF-7) cell line using MTT assay. Ethyl p-hydroxycinnamate (EPHC) was most cytotoxic against MCF-7 at 1000 μg/mL where percentage of cell viability was 9.87 %, while IC50 was 340 μg/mL. EPHC showed slightly higher cytotoxicity activity compared to EPMC. The results of this study show that the biotransformation process was able to produce a metabolite (EPHC) with higher cytotoxicity activity compared to its parent compound (EPMC).
format	Article
author	Omar, Muhammad Nor Hasali, Nor Hazwani Yarmo, Mohd Ambar
author_facet	Omar, Muhammad Nor Hasali, Nor Hazwani Yarmo, Mohd Ambar
author_sort	Omar, Muhammad Nor
title	Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger
title_short	Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger
title_full	Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger
title_fullStr	Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger
title_full_unstemmed	Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger
title_sort	cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by aspergillus niger
publisher	Oriental Scientific Publishing Company
publishDate	2016
url	http://irep.iium.edu.my/54229/ http://irep.iium.edu.my/54229/ http://irep.iium.edu.my/54229/ http://irep.iium.edu.my/54229/1/PROF%20NO%20OJC_Vol32_No5_p_2731-2734-2.pdf http://irep.iium.edu.my/54229/7/54229_Cytotoxicity%20Activity%20of%20Biotransformed%20Ethyl_WOS.pdf http://irep.iium.edu.my/54229/8/54229_Cytotoxicity%20Activity%20of%20Biotransformed%20Ethyl_SCOPUS.pdf
first_indexed	2023-09-18T21:16:43Z
last_indexed	2023-09-18T21:16:43Z
_version_	1777411611850440704

Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger

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