Changes in leptin in relation to increased testosterone levels associated with Eurycoma Longifolia Jack (Tongkat Ali) root extract consumption in male rats

Objectives: Eurycoma longifolia jack root extract has been known for its aphrodisiac and anabolic properties. Our study aimed at investigating the effects of this extract on the serum leptin in relation to the well-known effects on testosterone levels of male rats. Methodology: Twenty-four mature ma...

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Main Authors:	Faisal, Ghasak Ghazi, Haque, Mainul, Najmuldeen, Ghazi Faisal, Mustafa Al-Ahmad, Basma Ezzat, Al-Ani, Ali Sabri Radeef, Alattraqchi, Ahmed Ghazi
Format:	Article
Language:	English English English
Published:	Phcog.Net 2017
Subjects:	RB Pathology
Online Access:	http://irep.iium.edu.my/54399/ http://irep.iium.edu.my/54399/ http://irep.iium.edu.my/54399/1/Changes%20in%20Leptin%20in%20Relation%20to%20Increased%20Testosterone%20Levels%20Associated%20with%20Eurycoma%20Longifolia%20Jack%20%28Tongkat%20Ali%29%20Root%20Extract%20Consumption%20in%20Male%20Rats.pdf http://irep.iium.edu.my/54399/7/54399_Changes%20in%20leptin%20in%20relation%20to%20increased%20testosterone_Scopus.pdf http://irep.iium.edu.my/54399/8/54399_Changes%20in%20leptin%20in%20relation%20to%20increased%20testosterone_WoS.pdf

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spelling	iium-543992018-04-16T03:09:50Z http://irep.iium.edu.my/54399/ Changes in leptin in relation to increased testosterone levels associated with Eurycoma Longifolia Jack (Tongkat Ali) root extract consumption in male rats Faisal, Ghasak Ghazi Haque, Mainul Najmuldeen, Ghazi Faisal Mustafa Al-Ahmad, Basma Ezzat Al-Ani, Ali Sabri Radeef Alattraqchi, Ahmed Ghazi RB Pathology Objectives: Eurycoma longifolia jack root extract has been known for its aphrodisiac and anabolic properties. Our study aimed at investigating the effects of this extract on the serum leptin in relation to the well-known effects on testosterone levels of male rats. Methodology: Twenty-four mature male Albino Wistar rats were used in this study. The rats were divided into 3 groups; control, group A and group B. Body weight was recorded for the rats in all groups. Group A received 5mg/kg twice daily of pure Eurycoma Longifolia root extract. Group B received 10mg/kg twice daily of the same extract. The duration of treatment was 6 weeks at the end of which, serum leptin and testosterone levels were analyzed in all groups and body weight recorded. Results: The mean serum leptin and testosterone levels for the control were 1.13±0.13ng/ml and 0.79±0.07ng/ml respectively. While for group A were1.09±0.19ng/ml, 0.89±0.16ng/ml and for Group B were 0.89±0.16ng/ml,1.75±0.1ng/ml respectively. The rats in the treated groups showed decrease in body weight in comparison to the control which was not significant in group A (p=0.867) and significant in group B (p=0.042). Statistical analysis showed that the serum leptin level of group B was significantly lower than that of control group (p=0.001) and group A (p=0.03). On the other hand, no significant difference in serum leptin levels was observed between the control group and group A. The serum testosterone level was significantly higher in group B than control and group A while group A did not show a statistically significant difference than control. Conclusion: Eurycoma Longifolia root extract can significantly decrease serum leptin levels in relation to the rise in serum testosterone levels. Eurycoma Longifolia consumption also causes a significant decrease in total body weight pointing to the possibility of decreased body fat content. Phcog.Net 2017-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/54399/1/Changes%20in%20Leptin%20in%20Relation%20to%20Increased%20Testosterone%20Levels%20Associated%20with%20Eurycoma%20Longifolia%20Jack%20%28Tongkat%20Ali%29%20Root%20Extract%20Consumption%20in%20Male%20Rats.pdf application/pdf en http://irep.iium.edu.my/54399/7/54399_Changes%20in%20leptin%20in%20relation%20to%20increased%20testosterone_Scopus.pdf application/pdf en http://irep.iium.edu.my/54399/8/54399_Changes%20in%20leptin%20in%20relation%20to%20increased%20testosterone_WoS.pdf Faisal, Ghasak Ghazi and Haque, Mainul and Najmuldeen, Ghazi Faisal and Mustafa Al-Ahmad, Basma Ezzat and Al-Ani, Ali Sabri Radeef and Alattraqchi, Ahmed Ghazi (2017) Changes in leptin in relation to increased testosterone levels associated with Eurycoma Longifolia Jack (Tongkat Ali) root extract consumption in male rats. Journal of Young Pharmacists, 9 (1). pp. 40-42. ISSN 0975-1483 E-ISSN 0975-1505 http://www.jyoungpharm.org/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RB Pathology
spellingShingle	RB Pathology Faisal, Ghasak Ghazi Haque, Mainul Najmuldeen, Ghazi Faisal Mustafa Al-Ahmad, Basma Ezzat Al-Ani, Ali Sabri Radeef Alattraqchi, Ahmed Ghazi Changes in leptin in relation to increased testosterone levels associated with Eurycoma Longifolia Jack (Tongkat Ali) root extract consumption in male rats
description	Objectives: Eurycoma longifolia jack root extract has been known for its aphrodisiac and anabolic properties. Our study aimed at investigating the effects of this extract on the serum leptin in relation to the well-known effects on testosterone levels of male rats. Methodology: Twenty-four mature male Albino Wistar rats were used in this study. The rats were divided into 3 groups; control, group A and group B. Body weight was recorded for the rats in all groups. Group A received 5mg/kg twice daily of pure Eurycoma Longifolia root extract. Group B received 10mg/kg twice daily of the same extract. The duration of treatment was 6 weeks at the end of which, serum leptin and testosterone levels were analyzed in all groups and body weight recorded. Results: The mean serum leptin and testosterone levels for the control were 1.13±0.13ng/ml and 0.79±0.07ng/ml respectively. While for group A were1.09±0.19ng/ml, 0.89±0.16ng/ml and for Group B were 0.89±0.16ng/ml,1.75±0.1ng/ml respectively. The rats in the treated groups showed decrease in body weight in comparison to the control which was not significant in group A (p=0.867) and significant in group B (p=0.042). Statistical analysis showed that the serum leptin level of group B was significantly lower than that of control group (p=0.001) and group A (p=0.03). On the other hand, no significant difference in serum leptin levels was observed between the control group and group A. The serum testosterone level was significantly higher in group B than control and group A while group A did not show a statistically significant difference than control. Conclusion: Eurycoma Longifolia root extract can significantly decrease serum leptin levels in relation to the rise in serum testosterone levels. Eurycoma Longifolia consumption also causes a significant decrease in total body weight pointing to the possibility of decreased body fat content.
format	Article
author	Faisal, Ghasak Ghazi Haque, Mainul Najmuldeen, Ghazi Faisal Mustafa Al-Ahmad, Basma Ezzat Al-Ani, Ali Sabri Radeef Alattraqchi, Ahmed Ghazi
author_facet	Faisal, Ghasak Ghazi Haque, Mainul Najmuldeen, Ghazi Faisal Mustafa Al-Ahmad, Basma Ezzat Al-Ani, Ali Sabri Radeef Alattraqchi, Ahmed Ghazi
author_sort	Faisal, Ghasak Ghazi
title	Changes in leptin in relation to increased testosterone levels associated with Eurycoma Longifolia Jack (Tongkat Ali) root extract consumption in male rats
title_short	Changes in leptin in relation to increased testosterone levels associated with Eurycoma Longifolia Jack (Tongkat Ali) root extract consumption in male rats
title_full	Changes in leptin in relation to increased testosterone levels associated with Eurycoma Longifolia Jack (Tongkat Ali) root extract consumption in male rats
title_fullStr	Changes in leptin in relation to increased testosterone levels associated with Eurycoma Longifolia Jack (Tongkat Ali) root extract consumption in male rats
title_full_unstemmed	Changes in leptin in relation to increased testosterone levels associated with Eurycoma Longifolia Jack (Tongkat Ali) root extract consumption in male rats
title_sort	changes in leptin in relation to increased testosterone levels associated with eurycoma longifolia jack (tongkat ali) root extract consumption in male rats
publisher	Phcog.Net
publishDate	2017
url	http://irep.iium.edu.my/54399/ http://irep.iium.edu.my/54399/ http://irep.iium.edu.my/54399/1/Changes%20in%20Leptin%20in%20Relation%20to%20Increased%20Testosterone%20Levels%20Associated%20with%20Eurycoma%20Longifolia%20Jack%20%28Tongkat%20Ali%29%20Root%20Extract%20Consumption%20in%20Male%20Rats.pdf http://irep.iium.edu.my/54399/7/54399_Changes%20in%20leptin%20in%20relation%20to%20increased%20testosterone_Scopus.pdf http://irep.iium.edu.my/54399/8/54399_Changes%20in%20leptin%20in%20relation%20to%20increased%20testosterone_WoS.pdf
first_indexed	2023-09-18T21:16:59Z
last_indexed	2023-09-18T21:16:59Z
_version_	1777411627758387200

Changes in leptin in relation to increased testosterone levels associated with Eurycoma Longifolia Jack (Tongkat Ali) root extract consumption in male rats

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