In vitro evaluations of anti-hyperglycemic ant antioxidant activities of Entada spiralis Ridl. stem bark extracts
Entada spiralis Ridl. (leguminoceae), locally known as “Sintok” or “ Beluru” is a woody climber that grows widely in Malaysia. Phytoconstituents of various crude extracts obtained from solvents of varying polarities were analyzed. The antioxidant and antihyperglycemic potentials of the extracts w...
| Main Authors: | , , , |
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| Format: | Conference or Workshop Item |
| Language: | English English |
| Published: |
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/54540/ http://irep.iium.edu.my/54540/ http://irep.iium.edu.my/54540/1/54540_Abstract.pdf http://irep.iium.edu.my/54540/2/54540_PAN-ASIAN%20POSTER.pdf |
| Summary: | Entada spiralis Ridl. (leguminoceae), locally known as “Sintok” or “ Beluru” is a
woody climber that grows widely in Malaysia. Phytoconstituents of various crude
extracts obtained from solvents of varying polarities were analyzed. The
antioxidant and antihyperglycemic potentials of the extracts were assessed using
DPPH, ABTS and α-glucosidase inhibitory methods respectively. Qualitative
analysis shows the presence of most of the phytochemicals in methanol extract
with chloroform and petroleum ether having terpenoid and tannins as their major
constituent respectively. Methanol extract contains highest amount of total
phenolics and flavonoids (42.5 ±15.85, 28.94±2.93). This extract also shows a very
high α-glucosidase inhibitory activity with IC50 value of 20.67. Chloroform and
methanol extracts exhibited good radical scavenging activities dose dependently.
This result suggests the medicinal potential of Entada spiralis Ridl. stem bark as a
therapeutic agent against hyperglycemia and free radical associated problems,
the potential which may be attributed to the presence of terpenoid, phenolics
and flavonoids. |
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