Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound

Despite most anticancer drugs possess potent cell killing activity in vitro studies; the selective delivery of drugs to cancer cells is thus far becomes a major challenge to oncology. The non-specific actions of drugs on healthy cells cause many restrictions in clinical use due to their systemic tox...

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Main Authors:	Sahabudin, Adzly H, Abdul Ghani, Radiah, Fong, Fiona How Ni
Format:	Conference or Workshop Item
Language:	English
Published:	Kulliyyah of Allied Health Sciences, IIUM 2016
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/54665/ http://irep.iium.edu.my/54665/7/54665%20Comparison%20between%20Cold%20Temperature.pdf

id	iium-54665
recordtype	eprints
spelling	iium-546652018-06-29T03:19:11Z http://irep.iium.edu.my/54665/ Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound Sahabudin, Adzly H Abdul Ghani, Radiah Fong, Fiona How Ni QD Chemistry Despite most anticancer drugs possess potent cell killing activity in vitro studies; the selective delivery of drugs to cancer cells is thus far becomes a major challenge to oncology. The non-specific actions of drugs on healthy cells cause many restrictions in clinical use due to their systemic toxicity. In respond to this matter, specific targeting of anticancer drugs towards cancer cells can be achieved by attaching them to a molecule that is transported into cancer cells via a selective transport system. Carbon disulphides were attached to a polyamine to reduce the effects of cancer cells as sulphurs were known for its anti-cancer properties. For the synthesis, two methods were used. The first method involved the synthesis done in a cold environment while the other in a room temperature environment. The temperature differences had shown to influence the yield as well as the chemical structure of the drug. The effect could also be seen on the amount of solvent used during the process. For the room temperature mediated synthesis, the formation of solid compounds produce was higher and faster as compared to the cold mediated synthesis. Repetition of both methods showed that it was dependable as it produced the same compounds based on the Fourier transformed infrared spectroscopy results. In comparison, the room temp mediated synthesis was more efficient as it produced better yield. Kulliyyah of Allied Health Sciences, IIUM 2016 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/54665/7/54665%20Comparison%20between%20Cold%20Temperature.pdf Sahabudin, Adzly H and Abdul Ghani, Radiah and Fong, Fiona How Ni (2016) Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound. In: KAHS Research Week (KRW) 2016 in conjunction with 1st Allied Health Scientific Colloquium (AHSC) 2016, 21 - 25 November 2016, Pahang, Malaysia.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Sahabudin, Adzly H Abdul Ghani, Radiah Fong, Fiona How Ni Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound
description	Despite most anticancer drugs possess potent cell killing activity in vitro studies; the selective delivery of drugs to cancer cells is thus far becomes a major challenge to oncology. The non-specific actions of drugs on healthy cells cause many restrictions in clinical use due to their systemic toxicity. In respond to this matter, specific targeting of anticancer drugs towards cancer cells can be achieved by attaching them to a molecule that is transported into cancer cells via a selective transport system. Carbon disulphides were attached to a polyamine to reduce the effects of cancer cells as sulphurs were known for its anti-cancer properties. For the synthesis, two methods were used. The first method involved the synthesis done in a cold environment while the other in a room temperature environment. The temperature differences had shown to influence the yield as well as the chemical structure of the drug. The effect could also be seen on the amount of solvent used during the process. For the room temperature mediated synthesis, the formation of solid compounds produce was higher and faster as compared to the cold mediated synthesis. Repetition of both methods showed that it was dependable as it produced the same compounds based on the Fourier transformed infrared spectroscopy results. In comparison, the room temp mediated synthesis was more efficient as it produced better yield.
format	Conference or Workshop Item
author	Sahabudin, Adzly H Abdul Ghani, Radiah Fong, Fiona How Ni
author_facet	Sahabudin, Adzly H Abdul Ghani, Radiah Fong, Fiona How Ni
author_sort	Sahabudin, Adzly H
title	Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound
title_short	Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound
title_full	Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound
title_fullStr	Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound
title_full_unstemmed	Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound
title_sort	comparison between cold temperature (≤ 4°c) and room temperature (≈25°c) mediated synthesis for putrescine-sulphur compound
publisher	Kulliyyah of Allied Health Sciences, IIUM
publishDate	2016
url	http://irep.iium.edu.my/54665/ http://irep.iium.edu.my/54665/7/54665%20Comparison%20between%20Cold%20Temperature.pdf
first_indexed	2023-09-18T21:17:19Z
last_indexed	2023-09-18T21:17:19Z
_version_	1777411649421967360

Comparison between cold temperature (≤ 4°C) and room temperature (≈25°C) mediated synthesis for putrescine-sulphur compound

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