Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients
Objective: To prove probable relations between serum E3 SUMO-protein ligase NSE2 (NSMCE2) concentration, peroxynitrite related to oxidative stress in nephrolithiasis patients. Methods: A total of 60 patients with nephrolithiasis and 50 healthy volunteers were involved in this study. Colorimetric...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Elsevier BV
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/54726/ http://irep.iium.edu.my/54726/ http://irep.iium.edu.my/54726/ http://irep.iium.edu.my/54726/13/54726_Serum%20E3%20SUMO-protein.pdf http://irep.iium.edu.my/54726/14/54726_Serum%20E3%20SUMO-protein_SCOPUS.pdf |
| Summary: | Objective: To prove probable relations between serum E3 SUMO-protein ligase NSE2 (NSMCE2) concentration, peroxynitrite related to oxidative stress in nephrolithiasis
patients.
Methods: A total of 60 patients with nephrolithiasis and 50 healthy volunteers were
involved in this study. Colorimetric method was used to detect blood urea, creatinine, uric
acid, protein, albumin, total antioxidant status, total oxidant status, peroxynitrite, nitric
oxide and oxidative stress index. Glutathione, NSMCE2 and superoxide dismutase were
measured by ELISA.
Results: A significant increase in level of peroxynitrite, total oxidant status, NSMCE2
and oxidative stress index in patients was observed, while total antioxidant status and
glutathione were significantly decreased.
Conclusions: The study concluded that serum NSMCE2 significantly correlated with
peroxynitrite and oxidative stress in patients with nephrolithiasis. |
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