Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes)

Postmenopausal osteoporosis is one of the main health problems in aging women. It was due to several factors including oxidative stress, which can be controlled through intake of antioxidants from food sources. Virgin coconut oil (VCO) is one of the natural product rich in an...

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Main Authors:	Abdul-Hamid, Shidqiyyah, Muhammad, Norliza, Naina Mohamed, Isa
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2016
Subjects:	R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/54872/ http://irep.iium.edu.my/54872/ http://irep.iium.edu.my/54872/1/05%20Shidqiyyah.pdf

id	iium-54872
recordtype	eprints
spelling	iium-548722017-07-18T06:05:58Z http://irep.iium.edu.my/54872/ Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes) Abdul-Hamid, Shidqiyyah Muhammad, Norliza Naina Mohamed, Isa R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica Postmenopausal osteoporosis is one of the main health problems in aging women. It was due to several factors including oxidative stress, which can be controlled through intake of antioxidants from food sources. Virgin coconut oil (VCO) is one of the natural product rich in antioxidants and has been proven to protect osteoporotic bone. This study was conducted to gain in-depth understanding on virgin coconut oil’s activity on osteoporosis at molecular level. Thirty two female Sprague-Dawley rats were divided into four groups, namely Sham operated group, ovariectomized control group (Ovx+Ctrl), ovariectomized with VCO treatment (Ovx+ VCO), and ovariectomized with estrogen treatment (Ovx+E). All treatments were administered orally for ten weeks. Bone samples were obtained to examine changes on expression of superoxide dismutase (SOD),glutathione peroxidase (GPX), osteocalcin and runt-related transcription factor 2 (Runx2) genes. The results indicated that rats receiving VCO treatment had experienced significant increments in SOD, GPX and osteocalcin gene expressions compared to the ovariectomized control group, besides the gene expressions of Runx2 which also showed an increment pattern. In conclusion, VCO helps to protect bone in osteoporotic rat model by increasing the expressions of antioxidant genes and genes which increase the osteoblast acitivities. Universiti Kebangsaan Malaysia 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/54872/1/05%20Shidqiyyah.pdf Abdul-Hamid, Shidqiyyah and Muhammad, Norliza and Naina Mohamed, Isa (2016) Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes). Sains Malaysiana, 45 (12). pp. 1815-1822. ISSN 0126-6039 http://www.ukm.my/jsm/pdf_files/SM-PDF-45-12-2016/05%20Shidqiyyah.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica
spellingShingle	R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica Abdul-Hamid, Shidqiyyah Muhammad, Norliza Naina Mohamed, Isa Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes)
description	Postmenopausal osteoporosis is one of the main health problems in aging women. It was due to several factors including oxidative stress, which can be controlled through intake of antioxidants from food sources. Virgin coconut oil (VCO) is one of the natural product rich in antioxidants and has been proven to protect osteoporotic bone. This study was conducted to gain in-depth understanding on virgin coconut oil’s activity on osteoporosis at molecular level. Thirty two female Sprague-Dawley rats were divided into four groups, namely Sham operated group, ovariectomized control group (Ovx+Ctrl), ovariectomized with VCO treatment (Ovx+ VCO), and ovariectomized with estrogen treatment (Ovx+E). All treatments were administered orally for ten weeks. Bone samples were obtained to examine changes on expression of superoxide dismutase (SOD),glutathione peroxidase (GPX), osteocalcin and runt-related transcription factor 2 (Runx2) genes. The results indicated that rats receiving VCO treatment had experienced significant increments in SOD, GPX and osteocalcin gene expressions compared to the ovariectomized control group, besides the gene expressions of Runx2 which also showed an increment pattern. In conclusion, VCO helps to protect bone in osteoporotic rat model by increasing the expressions of antioxidant genes and genes which increase the osteoblast acitivities.
format	Article
author	Abdul-Hamid, Shidqiyyah Muhammad, Norliza Naina Mohamed, Isa
author_facet	Abdul-Hamid, Shidqiyyah Muhammad, Norliza Naina Mohamed, Isa
author_sort	Abdul-Hamid, Shidqiyyah
title	Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes)
title_short	Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes)
title_full	Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes)
title_fullStr	Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes)
title_full_unstemmed	Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes)
title_sort	tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes)
publisher	Universiti Kebangsaan Malaysia
publishDate	2016
url	http://irep.iium.edu.my/54872/ http://irep.iium.edu.my/54872/ http://irep.iium.edu.my/54872/1/05%20Shidqiyyah.pdf
first_indexed	2023-09-18T21:17:35Z
last_indexed	2023-09-18T21:17:35Z
_version_	1777411665446305792

Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: analisis gen Osteoblastogenesis dan antioksidan ( the effects of virgin coconut oil on postmenopausal osteoporotic bone: analyses on osteoblastogenesis and antioxidant genes)

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