Examining the safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam

This paper examines the safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam. The first clinical trial treating adenosine deaminase deficient SCID patients conducted in 1990 has triggered the development of gene transfer technology. The potential...

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Main Authors:	Md Nazir, Noorhidayah, Sha'ban, Munirah
Format:	Conference or Workshop Item
Language:	English
Published:	IIUM 2016
Subjects:	TA164 Bioengineering
Online Access:	http://irep.iium.edu.my/55030/ http://irep.iium.edu.my/55030/1/Noorhidayah%202WCII2016%20Abstract.pdf

id	iium-55030
recordtype	eprints
spelling	iium-550302017-02-11T17:42:55Z http://irep.iium.edu.my/55030/ Examining the safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam Md Nazir, Noorhidayah Sha'ban, Munirah TA164 Bioengineering This paper examines the safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam. The first clinical trial treating adenosine deaminase deficient SCID patients conducted in 1990 has triggered the development of gene transfer technology. The potential of gene transfer is further explored in tissue engineering field with the hope it could prosper the regenerative medicine application. However, ethical issues become a hot topic when it comes to application of new treatment modalities, primarily in gene transfer because of genetic modification influences the basis of life - the DNA. Besides ethical issue, the application of gene transfer in treating diseases also attract views from religious context. The questions on the techniques to administer the gene in human, social acceptance of genetically modified cell and adverse effects from it are still debatable and unresolved. A part from that dilemma, both safety and efficacy issues are raised due to the scientific uncertainty and social perception of the technology. Despite countless number of encouraging findings and recommendations by the proponents of the technology, gene transfer is currently available only in a research setting. This paper outlines the safety and efficacy involved in gene transfer for cartilage tissue engineering application. The established guidelines are used to complement and provide the necessary foundations in discussing the aspects involved in the incorporation of gene transfer with cartilage tissue engineering. Relevant Islamic input are identified and aligned to those particular guidelines. It is hoped that the integration of Islamic inputs in the existing guidelines could suggest the safest approach in treating cartilage degeneration disease and other diseases through gene transfer technology. IIUM 2016-10-21 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/55030/1/Noorhidayah%202WCII2016%20Abstract.pdf Md Nazir, Noorhidayah and Sha'ban, Munirah (2016) Examining the safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam. In: 2nd World Congress on Integration and Islamicisation: Focus On Medical and Health Care Sciences, 21-23 Oct 2016, Kuantan.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TA164 Bioengineering
spellingShingle	TA164 Bioengineering Md Nazir, Noorhidayah Sha'ban, Munirah Examining the safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam
description	This paper examines the safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam. The first clinical trial treating adenosine deaminase deficient SCID patients conducted in 1990 has triggered the development of gene transfer technology. The potential of gene transfer is further explored in tissue engineering field with the hope it could prosper the regenerative medicine application. However, ethical issues become a hot topic when it comes to application of new treatment modalities, primarily in gene transfer because of genetic modification influences the basis of life - the DNA. Besides ethical issue, the application of gene transfer in treating diseases also attract views from religious context. The questions on the techniques to administer the gene in human, social acceptance of genetically modified cell and adverse effects from it are still debatable and unresolved. A part from that dilemma, both safety and efficacy issues are raised due to the scientific uncertainty and social perception of the technology. Despite countless number of encouraging findings and recommendations by the proponents of the technology, gene transfer is currently available only in a research setting. This paper outlines the safety and efficacy involved in gene transfer for cartilage tissue engineering application. The established guidelines are used to complement and provide the necessary foundations in discussing the aspects involved in the incorporation of gene transfer with cartilage tissue engineering. Relevant Islamic input are identified and aligned to those particular guidelines. It is hoped that the integration of Islamic inputs in the existing guidelines could suggest the safest approach in treating cartilage degeneration disease and other diseases through gene transfer technology.
format	Conference or Workshop Item
author	Md Nazir, Noorhidayah Sha'ban, Munirah
author_facet	Md Nazir, Noorhidayah Sha'ban, Munirah
author_sort	Md Nazir, Noorhidayah
title	Examining the safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam
title_short	Examining the safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam
title_full	Examining the safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam
title_fullStr	Examining the safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam
title_full_unstemmed	Examining the safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam
title_sort	examining the safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of islam
publisher	IIUM
publishDate	2016
url	http://irep.iium.edu.my/55030/ http://irep.iium.edu.my/55030/1/Noorhidayah%202WCII2016%20Abstract.pdf
first_indexed	2023-09-18T21:17:48Z
last_indexed	2023-09-18T21:17:48Z
_version_	1777411679299043328

Examining the safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam

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