Effects of Eurycoma longifolia on the reproductive cycle of female rats

The benefits of Eurycoma longifolia for male reproductive enhancement have long been known but little can be said for its use in females and the effects of the plant on the female reproductive system and functions. This study is carried out to investigate the effects of standardized extract from the...

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Main Authors:	Abdul Rahman, Suzanah, Ahmad, Nur Amalina, Abdul Samat, Nadia Hanis, Mohamad Zahri, Syazana, Abdullah, 'Afif Raihan
Format:	Conference or Workshop Item
Language:	English English
Published:	2016
Subjects:	RG Gynecology and obstetrics RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/55103/ http://irep.iium.edu.my/55103/ http://irep.iium.edu.my/55103/1/PASBC2016%20-%20Suzanah%20NPH-O-006%20-%20PDF.pdf http://irep.iium.edu.my/55103/8/PABSC2016.pdf

id	iium-55103
recordtype	eprints
spelling	iium-551032017-05-15T06:35:10Z http://irep.iium.edu.my/55103/ Effects of Eurycoma longifolia on the reproductive cycle of female rats Abdul Rahman, Suzanah Ahmad, Nur Amalina Abdul Samat, Nadia Hanis Mohamad Zahri, Syazana Abdullah, 'Afif Raihan RG Gynecology and obstetrics RM Therapeutics. Pharmacology The benefits of Eurycoma longifolia for male reproductive enhancement have long been known but little can be said for its use in females and the effects of the plant on the female reproductive system and functions. This study is carried out to investigate the effects of standardized extract from the roots of Eurycoma longifolia on the oestrous cycle and hormone levels in rats. Female Sprague Dawley rats of 7-8 weeks old, weighing between 170-200g, were randomized into four groups of 6 animals each following examination of vaginal smears daily for two weeks covering 3 oestrous cycles. Rats in the treatment group received the extract orally at doses of 50, 75 and 100 mg/kg body weight for 14-days while the control group received an equal volume of distilled water in a similar manner. The oestrous cycle pattern of both control and treatment groups were observed daily and recorded for the whole of the duration including the body weights before and after the 14-days treatment. Blood samples were at the end of the study collected and the serum analysed for testosterone, oestradiol, progesterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels. Ovaries were removed, weighed and examined for histomorphological changes. Although some changes were observed on the analysed variables, data obtained did not indicate that the standardized extract of Eurycoma longifolia caused any detrimental effects on the female reproductive cycle and the ovary of the rats. Further investigations on effects of Eurycoma longifolia on the histopathology of the ovary may highlight the potential value of the plant in female reproductive disorders. 2016 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/55103/1/PASBC2016%20-%20Suzanah%20NPH-O-006%20-%20PDF.pdf application/pdf en http://irep.iium.edu.my/55103/8/PABSC2016.pdf Abdul Rahman, Suzanah and Ahmad, Nur Amalina and Abdul Samat, Nadia Hanis and Mohamad Zahri, Syazana and Abdullah, 'Afif Raihan (2016) Effects of Eurycoma longifolia on the reproductive cycle of female rats. In: 3rd Pan-Asian Biomedical Science Conference 2016 Kuala Lumpur, 7th–8th Dec. 2016, Kuala Lumpur. (Unpublished) https://sites.google.com/site/3rdpabsc2016/programme
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RG Gynecology and obstetrics RM Therapeutics. Pharmacology
spellingShingle	RG Gynecology and obstetrics RM Therapeutics. Pharmacology Abdul Rahman, Suzanah Ahmad, Nur Amalina Abdul Samat, Nadia Hanis Mohamad Zahri, Syazana Abdullah, 'Afif Raihan Effects of Eurycoma longifolia on the reproductive cycle of female rats
description	The benefits of Eurycoma longifolia for male reproductive enhancement have long been known but little can be said for its use in females and the effects of the plant on the female reproductive system and functions. This study is carried out to investigate the effects of standardized extract from the roots of Eurycoma longifolia on the oestrous cycle and hormone levels in rats. Female Sprague Dawley rats of 7-8 weeks old, weighing between 170-200g, were randomized into four groups of 6 animals each following examination of vaginal smears daily for two weeks covering 3 oestrous cycles. Rats in the treatment group received the extract orally at doses of 50, 75 and 100 mg/kg body weight for 14-days while the control group received an equal volume of distilled water in a similar manner. The oestrous cycle pattern of both control and treatment groups were observed daily and recorded for the whole of the duration including the body weights before and after the 14-days treatment. Blood samples were at the end of the study collected and the serum analysed for testosterone, oestradiol, progesterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels. Ovaries were removed, weighed and examined for histomorphological changes. Although some changes were observed on the analysed variables, data obtained did not indicate that the standardized extract of Eurycoma longifolia caused any detrimental effects on the female reproductive cycle and the ovary of the rats. Further investigations on effects of Eurycoma longifolia on the histopathology of the ovary may highlight the potential value of the plant in female reproductive disorders.
format	Conference or Workshop Item
author	Abdul Rahman, Suzanah Ahmad, Nur Amalina Abdul Samat, Nadia Hanis Mohamad Zahri, Syazana Abdullah, 'Afif Raihan
author_facet	Abdul Rahman, Suzanah Ahmad, Nur Amalina Abdul Samat, Nadia Hanis Mohamad Zahri, Syazana Abdullah, 'Afif Raihan
author_sort	Abdul Rahman, Suzanah
title	Effects of Eurycoma longifolia on the reproductive cycle of female rats
title_short	Effects of Eurycoma longifolia on the reproductive cycle of female rats
title_full	Effects of Eurycoma longifolia on the reproductive cycle of female rats
title_fullStr	Effects of Eurycoma longifolia on the reproductive cycle of female rats
title_full_unstemmed	Effects of Eurycoma longifolia on the reproductive cycle of female rats
title_sort	effects of eurycoma longifolia on the reproductive cycle of female rats
publishDate	2016
url	http://irep.iium.edu.my/55103/ http://irep.iium.edu.my/55103/ http://irep.iium.edu.my/55103/1/PASBC2016%20-%20Suzanah%20NPH-O-006%20-%20PDF.pdf http://irep.iium.edu.my/55103/8/PABSC2016.pdf
first_indexed	2023-09-18T21:17:54Z
last_indexed	2023-09-18T21:17:54Z
_version_	1777411686330793984

Effects of Eurycoma longifolia on the reproductive cycle of female rats

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