Co-prescription of opioids with benzodiazepine and other co-medications among opioid users: differential in opioid doses

Purpose: This study investigated the patterns of opioid co-prescription with benzodiazepine and other concomitant medications among opioid users. Opioid dose in each type of co-prescription was also examined. Patients and methods: This cross-sectional study was conducted among opioid users receiv...

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Main Authors:	Zin, Che Suraya, Ismail, Fadhilah
Format:	Article
Language:	English English
Published:	Dove Medical Press Ltd. 2017
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/55156/ http://irep.iium.edu.my/55156/ http://irep.iium.edu.my/55156/ http://irep.iium.edu.my/55156/3/55156.pdf http://irep.iium.edu.my/55156/4/55156-Co-prescription%20of%20opioids%20with%20benzodiazepine%20and%20other%20co-medications%20among%20opioid%20users_SCOPUS.pdf

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spelling	iium-551562018-03-19T00:40:11Z http://irep.iium.edu.my/55156/ Co-prescription of opioids with benzodiazepine and other co-medications among opioid users: differential in opioid doses Zin, Che Suraya Ismail, Fadhilah RS Pharmacy and materia medica Purpose: This study investigated the patterns of opioid co-prescription with benzodiazepine and other concomitant medications among opioid users. Opioid dose in each type of co-prescription was also examined. Patients and methods: This cross-sectional study was conducted among opioid users receiving concomitant medications at an outpatient tertiary hospital setting in Malaysia. Opioid prescriptions (morphine, fentanyl, oxycodone, dihydrocodeine and tramadol) that were co-prescribed with other medications (opioid + benzodiazepines, opioid + antidepressants, opioid + anticonvulsants, opioid + antipsychotics and opioid + hypnotics) dispensed from January 2013 to December 2014 were identified. The number of patients, number of co-prescriptions and the individual mean opioid daily dose in each type of co-prescription were calculated. Results: A total of 276 patients receiving 1059 co-prescription opioids with benzodiazepine and other co-medications were identified during the study period. Of these, 12.3% of patients received co-prescriptions of opioid + benzodiazepine, 19.3% received opioid + anticonvulsant, 6.3% received opioid + antidepressant and 10.9% received other co-prescriptions, including antipsychotics and hypnotics. The individual mean opioid dose was <100 mg/d of morphine equivalents in all types of co-prescriptions, and the dose ranged from 31 to 66 mg/d in the coprescriptions of opioid + benzodiazepine. Conclusion: Among the opioid users receiving concomitant medications, the co-prescriptions of opioid with benzodiazepine were prescribed to 12.3% of patients, and the individual opioid dose in this co-prescription was moderate. Other co-medications were also commonly used, and their opioid doses were within the recommended dose. Future studies are warranted to evaluate the adverse effect and clinical outcomes of the co-medications particularly in long-term opioid users with chronic non-cancer pain. Dove Medical Press Ltd. 2017-01-25 Article PeerReviewed application/pdf en http://irep.iium.edu.my/55156/3/55156.pdf application/pdf en http://irep.iium.edu.my/55156/4/55156-Co-prescription%20of%20opioids%20with%20benzodiazepine%20and%20other%20co-medications%20among%20opioid%20users_SCOPUS.pdf Zin, Che Suraya and Ismail, Fadhilah (2017) Co-prescription of opioids with benzodiazepine and other co-medications among opioid users: differential in opioid doses. Journal of Pain Research, 10. pp. 249-257. ISSN 1178-7090 https://www.dovepress.com/co-prescription-of-opioids-with-benzodiazepine-and-other-co-medication-peer-reviewed-article-JPR 10.2147/JPR.S122853
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Zin, Che Suraya Ismail, Fadhilah Co-prescription of opioids with benzodiazepine and other co-medications among opioid users: differential in opioid doses
description	Purpose: This study investigated the patterns of opioid co-prescription with benzodiazepine and other concomitant medications among opioid users. Opioid dose in each type of co-prescription was also examined. Patients and methods: This cross-sectional study was conducted among opioid users receiving concomitant medications at an outpatient tertiary hospital setting in Malaysia. Opioid prescriptions (morphine, fentanyl, oxycodone, dihydrocodeine and tramadol) that were co-prescribed with other medications (opioid + benzodiazepines, opioid + antidepressants, opioid + anticonvulsants, opioid + antipsychotics and opioid + hypnotics) dispensed from January 2013 to December 2014 were identified. The number of patients, number of co-prescriptions and the individual mean opioid daily dose in each type of co-prescription were calculated. Results: A total of 276 patients receiving 1059 co-prescription opioids with benzodiazepine and other co-medications were identified during the study period. Of these, 12.3% of patients received co-prescriptions of opioid + benzodiazepine, 19.3% received opioid + anticonvulsant, 6.3% received opioid + antidepressant and 10.9% received other co-prescriptions, including antipsychotics and hypnotics. The individual mean opioid dose was <100 mg/d of morphine equivalents in all types of co-prescriptions, and the dose ranged from 31 to 66 mg/d in the coprescriptions of opioid + benzodiazepine. Conclusion: Among the opioid users receiving concomitant medications, the co-prescriptions of opioid with benzodiazepine were prescribed to 12.3% of patients, and the individual opioid dose in this co-prescription was moderate. Other co-medications were also commonly used, and their opioid doses were within the recommended dose. Future studies are warranted to evaluate the adverse effect and clinical outcomes of the co-medications particularly in long-term opioid users with chronic non-cancer pain.
format	Article
author	Zin, Che Suraya Ismail, Fadhilah
author_facet	Zin, Che Suraya Ismail, Fadhilah
author_sort	Zin, Che Suraya
title	Co-prescription of opioids with benzodiazepine and other co-medications among opioid users: differential in opioid doses
title_short	Co-prescription of opioids with benzodiazepine and other co-medications among opioid users: differential in opioid doses
title_full	Co-prescription of opioids with benzodiazepine and other co-medications among opioid users: differential in opioid doses
title_fullStr	Co-prescription of opioids with benzodiazepine and other co-medications among opioid users: differential in opioid doses
title_full_unstemmed	Co-prescription of opioids with benzodiazepine and other co-medications among opioid users: differential in opioid doses
title_sort	co-prescription of opioids with benzodiazepine and other co-medications among opioid users: differential in opioid doses
publisher	Dove Medical Press Ltd.
publishDate	2017
url	http://irep.iium.edu.my/55156/ http://irep.iium.edu.my/55156/ http://irep.iium.edu.my/55156/ http://irep.iium.edu.my/55156/3/55156.pdf http://irep.iium.edu.my/55156/4/55156-Co-prescription%20of%20opioids%20with%20benzodiazepine%20and%20other%20co-medications%20among%20opioid%20users_SCOPUS.pdf
first_indexed	2023-09-18T21:17:58Z
last_indexed	2023-09-18T21:17:58Z
_version_	1777411689997664256

Co-prescription of opioids with benzodiazepine and other co-medications among opioid users: differential in opioid doses

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