Model of a critical size defect in the New Zealand White rabbit’s tibia

Introduction: Critical size defects (CSD) in the long bones of New Zealand White rabbit (Oryctolagus cuniculus) have been used for years as an experimental model for investigation of the effectiveness of a new bone substitute materials. There are varieties of protocols available in the literature...

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Main Authors:	Che Seman, Che Nor Zarida, Zakaria@Mohamad, Zamzuri, Mohamed Amin, Mohamed Azril, Awang, Mohd Shukrimi, Mohd Yusof, Nazri, Buyong, Zunariah
Format:	Article
Language:	English
Published:	Kulliyyah of Medicine, IIUM, Kuantan 2016
Subjects:	RD701 Orthopedics
Online Access:	http://irep.iium.edu.my/55462/ http://irep.iium.edu.my/55462/ http://irep.iium.edu.my/55462/1/Model%20of%20a%20critical%20size%20defect%20in%20the%20New%20Zealand%20White%20rabbit%E2%80%99s%20tibia.pdf

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spelling	iium-554622017-10-19T02:20:28Z http://irep.iium.edu.my/55462/ Model of a critical size defect in the New Zealand White rabbit’s tibia Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Mohamed Amin, Mohamed Azril Awang, Mohd Shukrimi Mohd Yusof, Nazri Buyong, Zunariah RD701 Orthopedics Introduction: Critical size defects (CSD) in the long bones of New Zealand White rabbit (Oryctolagus cuniculus) have been used for years as an experimental model for investigation of the effectiveness of a new bone substitute materials. There are varieties of protocols available in the literature. This technical note attempts to present an alternative surgical technique of a CSD in the New Zealand white rabbit tibia. Methods: Thirty-nine New Zealand White rabbits were used in this study. A CSD of approximately 4.5 mm (width) X 9.0 mm (length) was surgically drilled at the proximal tibial metaphysis, approximately 1 cm from the knee joint. The surrounding of soft tissue was repositioned and sutured layer by layer with bio absorbable surgical suture. Povidone soaked gauze and bandage were used as a dressing. There is no control group used in this study. Results: This alternative method created good CSD with less bleeding from the muscle observed.No mortality on other surgical complications were observed within 6 weeks, 12 weeks and 24 weeks following surgery. Conclusions: A simple and safe method for performing critical size defect was demonstrated and recommended as an approach for surgery on New Zealand White rabbits. Kulliyyah of Medicine, IIUM, Kuantan 2016-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/55462/1/Model%20of%20a%20critical%20size%20defect%20in%20the%20New%20Zealand%20White%20rabbit%E2%80%99s%20tibia.pdf Che Seman, Che Nor Zarida and Zakaria@Mohamad, Zamzuri and Mohamed Amin, Mohamed Azril and Awang, Mohd Shukrimi and Mohd Yusof, Nazri and Buyong, Zunariah (2016) Model of a critical size defect in the New Zealand White rabbit’s tibia. The International Medical Journal Malaysia ( IMJM ), 15 (Supplement Issue). p. 43. http://iiumedic.net/imjm/v1/vol-15-supplement-issue/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RD701 Orthopedics
spellingShingle	RD701 Orthopedics Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Mohamed Amin, Mohamed Azril Awang, Mohd Shukrimi Mohd Yusof, Nazri Buyong, Zunariah Model of a critical size defect in the New Zealand White rabbit’s tibia
description	Introduction: Critical size defects (CSD) in the long bones of New Zealand White rabbit (Oryctolagus cuniculus) have been used for years as an experimental model for investigation of the effectiveness of a new bone substitute materials. There are varieties of protocols available in the literature. This technical note attempts to present an alternative surgical technique of a CSD in the New Zealand white rabbit tibia. Methods: Thirty-nine New Zealand White rabbits were used in this study. A CSD of approximately 4.5 mm (width) X 9.0 mm (length) was surgically drilled at the proximal tibial metaphysis, approximately 1 cm from the knee joint. The surrounding of soft tissue was repositioned and sutured layer by layer with bio absorbable surgical suture. Povidone soaked gauze and bandage were used as a dressing. There is no control group used in this study. Results: This alternative method created good CSD with less bleeding from the muscle observed.No mortality on other surgical complications were observed within 6 weeks, 12 weeks and 24 weeks following surgery. Conclusions: A simple and safe method for performing critical size defect was demonstrated and recommended as an approach for surgery on New Zealand White rabbits.
format	Article
author	Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Mohamed Amin, Mohamed Azril Awang, Mohd Shukrimi Mohd Yusof, Nazri Buyong, Zunariah
author_facet	Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Mohamed Amin, Mohamed Azril Awang, Mohd Shukrimi Mohd Yusof, Nazri Buyong, Zunariah
author_sort	Che Seman, Che Nor Zarida
title	Model of a critical size defect in the New Zealand White rabbit’s tibia
title_short	Model of a critical size defect in the New Zealand White rabbit’s tibia
title_full	Model of a critical size defect in the New Zealand White rabbit’s tibia
title_fullStr	Model of a critical size defect in the New Zealand White rabbit’s tibia
title_full_unstemmed	Model of a critical size defect in the New Zealand White rabbit’s tibia
title_sort	model of a critical size defect in the new zealand white rabbit’s tibia
publisher	Kulliyyah of Medicine, IIUM, Kuantan
publishDate	2016
url	http://irep.iium.edu.my/55462/ http://irep.iium.edu.my/55462/ http://irep.iium.edu.my/55462/1/Model%20of%20a%20critical%20size%20defect%20in%20the%20New%20Zealand%20White%20rabbit%E2%80%99s%20tibia.pdf
first_indexed	2023-09-18T21:18:23Z
last_indexed	2023-09-18T21:18:23Z
_version_	1777411716119789568

Model of a critical size defect in the New Zealand White rabbit’s tibia

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