Preliminary screening of cytotoxic properties of Baccaurea angulata in several human cancer cell lines in vitro
Fruits have been acknowledged as a reservoir for numerous bioactive compounds. Baccaurea angulata, belonging to the Euphorbiaceae family, has been reported to contain several nutritional properties such as proteins and carbohydrates. Presently, B. angulata has not been fully exploited as little i...
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2013
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| Online Access: | http://irep.iium.edu.my/55650/ http://irep.iium.edu.my/55650/1/55650_abstract.pdf |
| Summary: | Fruits have been acknowledged as a reservoir for numerous bioactive compounds.
Baccaurea angulata, belonging to the Euphorbiaceae family, has been reported to contain
several nutritional properties such as proteins and carbohydrates. Presently, B. angulata
has not been fully exploited as little is known regarding its scientific properties. This
preliminary study aims to explore the cytotoxicity effects of various extracts and fibers of B.
angulata on human cancer cells. Cytotoxicity effects of B. angulata were evaluated on
cervix cancer (HeLa) and skin melanoma (A375) cells through treatment with hexane,
methanol and dichloromethane extracts of B. angulata as well as with novel B. angulata
fibers (whole fruit and berries) via direct contact method. The growth inhibitions of the
samples were evaluated through Methylene Blue Assay (MBA), with incubation time of 24,
48 and 72 hours. From the results, it was observed that for HeLa cells, berries showed the
highest growth inhibition (90.69 μg/mL, 72 hours). The solvent-based extracts were found
to be cytotoxic towards HeLa cells with methanol extracts exhibiting the highest
cytotoxicity with EC50 of 17.21 μg/mL. For A375 cells, all extracts also exhibited cytotoxic
effects, where the highest inhibition activity was induced by hexane extracts (89.40 μg/mL,
72 hours). Consequently, the study indicates that B. angulata fruit may have significant
growth inhibitory and cytotoxicity effects toward HeLa and A375 cells. It can be presumed
that B. angulata fruit has the potential to be used as a new alternative resource that could
be fundamental in future endeavors for prospective therapeutic treatments for cancer. |
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