Nephrotoxicity in chronic low dose organophosphate exposure
Objectives: People are exposed to chronic low dose organophosphates (OPs) pesticides through agriculture and pest control activities. Apparently, there were signifcant epidemiological reports suggesting pesticides role in chronic kidney disease. This observation is yet to be confrmed with appropri...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
College of Pathologists, Academy of Medicine Malaysia
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/55903/ http://irep.iium.edu.my/55903/ http://irep.iium.edu.my/55903/12/55903-Nephrotoxicity%20in%20chronic%20low%20dose%20organophosphate%20exposure.pdf |
| Summary: | Objectives: People are exposed to chronic low dose organophosphates (OPs) pesticides through agriculture and pest control
activities. Apparently, there were signifcant epidemiological reports suggesting pesticides role in chronic kidney disease. This
observation is yet to be confrmed with appropriate experimental model of chronic OPs exposure on animals. Thus, the aim of
this study is to observe for histomorphological characteristics related to nephropathy in the kidneys of rats upon exposure to
chronic low dose OPs. Materials and Methods: 24 males Sprague-Dawley rats were randomly divided into 3 groups of 6 rats each
with Group 1 as a Control group, whilst Group 2 and Group 3 received subcutaneous vehicle (3% dimethyl sulphoxide + 97%
v/v soy oil) and 18.0 mg/kg BW chlorpyrifos respectively, every other day for 180 days. After treatment, the rats were sacrifced
and the right kidney was subjected to routine H&E examination and specifc Masson-Trichrome and periodic-acid Schiff stain.
Results: OPs exposed group (Group 3) exhibited signifcant histo-morphological abnormalities suggesting cell injury, apoptosis
and degenerative changes in glomeruli and tubules. In contrast, the control groups 1 and 2 (vehicle) are spared. Conclusion:
Chronic low dose OPs exposure induced nephrotoxicity. The exact mechanism of nephrotoxicity should be further investigated. |
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