Modeling and analysis of a microresonating biosensor for detection of Salmonella bacteria in human blood

A new photonics biosensor configuration comprising a Double-side Ring Add-drop Filter microring resonator (DR-ADF) made from SiO2-TiO2 material is proposed for the detection of Salmonella bacteria (SB) in blood. The scattering matrix method using inductive calculation is used to determine the output...

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Main Authors:	Bahadoran, Mahdi, Ahmad Noorden, Ahmad Fakhrurrazi, Chaudhary, Kashif, Mohajer, Faeze Sadat, Aziz, Muhammad Safwan, Hashim, Shahrin, Ali, Jalil, Yupapin, Preecha P.
Format:	Article
Language:	English
Published:	Multidisciplinary Digital Publishing Institute (MDPI) 2014
Subjects:	QC Physics
Online Access:	http://irep.iium.edu.my/55989/ http://irep.iium.edu.my/55989/ http://irep.iium.edu.my/55989/ http://irep.iium.edu.my/55989/1/4Modeling%20and%20Analysis%20of%20a%20Microresonating%20Biosensor%20for.pdf

id	iium-55989
recordtype	eprints
spelling	iium-559892017-04-21T02:25:32Z http://irep.iium.edu.my/55989/ Modeling and analysis of a microresonating biosensor for detection of Salmonella bacteria in human blood Bahadoran, Mahdi Ahmad Noorden, Ahmad Fakhrurrazi Chaudhary, Kashif Mohajer, Faeze Sadat Aziz, Muhammad Safwan Hashim, Shahrin Ali, Jalil Yupapin, Preecha P. QC Physics A new photonics biosensor configuration comprising a Double-side Ring Add-drop Filter microring resonator (DR-ADF) made from SiO2-TiO2 material is proposed for the detection of Salmonella bacteria (SB) in blood. The scattering matrix method using inductive calculation is used to determine the output signal’s intensities in the blood with and without presence of Salmonella. The change in refractive index due to the reaction of Salmonella bacteria with its applied antibody on the flagellin layer loaded on the sensing and detecting microresonator causes the increase in through and dropper port’s intensities of the output signal which leads to the detection of SB in blood. A shift in the output signal wavelength is observed with resolution of 0.01 nm. The change in intensity and shift in wavelength is analyzed with respect to the change in the refractive index which contributes toward achieving an ultra-high sensitivity of 95,500 nm/RIU which is almost two orders higher than that of reported from single ring sensors and the limit of detection is in the order of 1 × 10−8 RIU. In applications, such a system can be employed for a high sensitive and fast detection of bacteria. Multidisciplinary Digital Publishing Institute (MDPI) 2014-07-18 Article PeerReviewed application/pdf en http://irep.iium.edu.my/55989/1/4Modeling%20and%20Analysis%20of%20a%20Microresonating%20Biosensor%20for.pdf Bahadoran, Mahdi and Ahmad Noorden, Ahmad Fakhrurrazi and Chaudhary, Kashif and Mohajer, Faeze Sadat and Aziz, Muhammad Safwan and Hashim, Shahrin and Ali, Jalil and Yupapin, Preecha P. (2014) Modeling and analysis of a microresonating biosensor for detection of Salmonella bacteria in human blood. Sensor, 14 (7). pp. 12885-12899. ISSN 1424-8220 http://www.mdpi.com/1424-8220/14/7/12885/htm 10.3390/s140712885
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QC Physics
spellingShingle	QC Physics Bahadoran, Mahdi Ahmad Noorden, Ahmad Fakhrurrazi Chaudhary, Kashif Mohajer, Faeze Sadat Aziz, Muhammad Safwan Hashim, Shahrin Ali, Jalil Yupapin, Preecha P. Modeling and analysis of a microresonating biosensor for detection of Salmonella bacteria in human blood
description	A new photonics biosensor configuration comprising a Double-side Ring Add-drop Filter microring resonator (DR-ADF) made from SiO2-TiO2 material is proposed for the detection of Salmonella bacteria (SB) in blood. The scattering matrix method using inductive calculation is used to determine the output signal’s intensities in the blood with and without presence of Salmonella. The change in refractive index due to the reaction of Salmonella bacteria with its applied antibody on the flagellin layer loaded on the sensing and detecting microresonator causes the increase in through and dropper port’s intensities of the output signal which leads to the detection of SB in blood. A shift in the output signal wavelength is observed with resolution of 0.01 nm. The change in intensity and shift in wavelength is analyzed with respect to the change in the refractive index which contributes toward achieving an ultra-high sensitivity of 95,500 nm/RIU which is almost two orders higher than that of reported from single ring sensors and the limit of detection is in the order of 1 × 10−8 RIU. In applications, such a system can be employed for a high sensitive and fast detection of bacteria.
format	Article
author	Bahadoran, Mahdi Ahmad Noorden, Ahmad Fakhrurrazi Chaudhary, Kashif Mohajer, Faeze Sadat Aziz, Muhammad Safwan Hashim, Shahrin Ali, Jalil Yupapin, Preecha P.
author_facet	Bahadoran, Mahdi Ahmad Noorden, Ahmad Fakhrurrazi Chaudhary, Kashif Mohajer, Faeze Sadat Aziz, Muhammad Safwan Hashim, Shahrin Ali, Jalil Yupapin, Preecha P.
author_sort	Bahadoran, Mahdi
title	Modeling and analysis of a microresonating biosensor for detection of Salmonella bacteria in human blood
title_short	Modeling and analysis of a microresonating biosensor for detection of Salmonella bacteria in human blood
title_full	Modeling and analysis of a microresonating biosensor for detection of Salmonella bacteria in human blood
title_fullStr	Modeling and analysis of a microresonating biosensor for detection of Salmonella bacteria in human blood
title_full_unstemmed	Modeling and analysis of a microresonating biosensor for detection of Salmonella bacteria in human blood
title_sort	modeling and analysis of a microresonating biosensor for detection of salmonella bacteria in human blood
publisher	Multidisciplinary Digital Publishing Institute (MDPI)
publishDate	2014
url	http://irep.iium.edu.my/55989/ http://irep.iium.edu.my/55989/ http://irep.iium.edu.my/55989/ http://irep.iium.edu.my/55989/1/4Modeling%20and%20Analysis%20of%20a%20Microresonating%20Biosensor%20for.pdf
first_indexed	2023-09-18T21:19:00Z
last_indexed	2023-09-18T21:19:00Z
_version_	1777411755396300800

Modeling and analysis of a microresonating biosensor for detection of Salmonella bacteria in human blood

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