Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition

The tumor microenvironment (TEM) comprise of various cellular and molecular components such as fibroblasts, immune cells, bone marrow-derived inflammatory cells, endothelial cells, extracellular matrix (ECM), and signaling molecules. The complex crosstalk between TEM components and signaling pathway...

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Main Authors:	Razak, Eliza, Yusof, Faridah, Ahmad Raus, Raha
Format:	Conference or Workshop Item
Language:	English
Published:	Kulliyyah of Engineering, International Islamic University Malaysia 2016
Subjects:	TA164 Bioengineering
Online Access:	http://irep.iium.edu.my/56373/ http://irep.iium.edu.my/56373/ http://irep.iium.edu.my/56373/19/56373.pdf

id	iium-56373
recordtype	eprints
spelling	iium-563732017-04-28T02:06:17Z http://irep.iium.edu.my/56373/ Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition Razak, Eliza Yusof, Faridah Ahmad Raus, Raha TA164 Bioengineering The tumor microenvironment (TEM) comprise of various cellular and molecular components such as fibroblasts, immune cells, bone marrow-derived inflammatory cells, endothelial cells, extracellular matrix (ECM), and signaling molecules. The complex crosstalk between TEM components and signaling pathways can give rise to tumorigenesis, progression, and angiogenesis as well as micro-metastasis and macro-metastasis. MicroRNAs (miRNAs) are small, non-coding extracellular RNAs involved in post-transcriptional regulation of gene silencing or degradation by base paring at open reading frame (ORF) region of the target mRNA. Recent advances in the miRNA field have driven to the understanding of multiple regulatory aspects concerning cancer biology. Acquisition of aberrant miRNA expression level in neoplastic tumor compared with normal tissue are promising biomarkers for cancer diagnosis. Epithelial-mesenchymal transition (EMT) is a reversible process in which neoplastic epithelial cells expressed mesenchymal phenotypes and resulting in alteration of cell autonomous mechanisms. EMT enables epithelial cells to lose their cell polarity, acquire cancer stem cell-like properties which favor tumor invasion, extravasation and metastasis. Mesenchymal–epithelial transition (MET) is the inverse process of EMT. This results in stabilization of distant metastases by permitting cancerous cells to recoup epithelial phenotypes and integrate into distant organs. Ectopic microRNA expression and disturbed signaling pathways have been associated with orchestrating EMT and MET processes. However, the exact molecular mechanisms behind oncogenic EMT and MET have remained widely elusive. This review describes the co-regulatory loops among miRNAs, target genes and important regulatory pathways involved in oncogenic EMT and MET. Kulliyyah of Engineering, International Islamic University Malaysia 2016 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/56373/19/56373.pdf Razak, Eliza and Yusof, Faridah and Ahmad Raus, Raha (2016) Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition. In: 4th International Conference on Biotechnology Engineering 2016 (ICBioE 2016), 25th-27th July 2016, Kuala Lumpur. http://www.iium.edu.my/icbioe/2016/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TA164 Bioengineering
spellingShingle	TA164 Bioengineering Razak, Eliza Yusof, Faridah Ahmad Raus, Raha Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition
description	The tumor microenvironment (TEM) comprise of various cellular and molecular components such as fibroblasts, immune cells, bone marrow-derived inflammatory cells, endothelial cells, extracellular matrix (ECM), and signaling molecules. The complex crosstalk between TEM components and signaling pathways can give rise to tumorigenesis, progression, and angiogenesis as well as micro-metastasis and macro-metastasis. MicroRNAs (miRNAs) are small, non-coding extracellular RNAs involved in post-transcriptional regulation of gene silencing or degradation by base paring at open reading frame (ORF) region of the target mRNA. Recent advances in the miRNA field have driven to the understanding of multiple regulatory aspects concerning cancer biology. Acquisition of aberrant miRNA expression level in neoplastic tumor compared with normal tissue are promising biomarkers for cancer diagnosis. Epithelial-mesenchymal transition (EMT) is a reversible process in which neoplastic epithelial cells expressed mesenchymal phenotypes and resulting in alteration of cell autonomous mechanisms. EMT enables epithelial cells to lose their cell polarity, acquire cancer stem cell-like properties which favor tumor invasion, extravasation and metastasis. Mesenchymal–epithelial transition (MET) is the inverse process of EMT. This results in stabilization of distant metastases by permitting cancerous cells to recoup epithelial phenotypes and integrate into distant organs. Ectopic microRNA expression and disturbed signaling pathways have been associated with orchestrating EMT and MET processes. However, the exact molecular mechanisms behind oncogenic EMT and MET have remained widely elusive. This review describes the co-regulatory loops among miRNAs, target genes and important regulatory pathways involved in oncogenic EMT and MET.
format	Conference or Workshop Item
author	Razak, Eliza Yusof, Faridah Ahmad Raus, Raha
author_facet	Razak, Eliza Yusof, Faridah Ahmad Raus, Raha
author_sort	Razak, Eliza
title	Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition
title_short	Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition
title_full	Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition
title_fullStr	Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition
title_full_unstemmed	Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition
title_sort	ectopic mirna network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition
publisher	Kulliyyah of Engineering, International Islamic University Malaysia
publishDate	2016
url	http://irep.iium.edu.my/56373/ http://irep.iium.edu.my/56373/ http://irep.iium.edu.my/56373/19/56373.pdf
first_indexed	2023-09-18T21:19:31Z
last_indexed	2023-09-18T21:19:31Z
_version_	1777411787181785088

Ectopic miRNA network and the crosstalk between different signalling pathways during epithelial–mesenchymal transition and mesenchymal–epithelial transition

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