Low inhibition of alpha-glucosidase and xanthine oxidase activities of ethanol extract of Momordica charantia fruit
Objective: To evaluate the α-glucosidase and xanthine oxidase inhibitory activities of different ethanolic and aqueous extracts of Momordica charantia fruit. Materials and Methods: The M. charantia fruits were extracted using different concentrations of ethanol in water (0, 20, 40, 60, 80 and 100...
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| Format: | Article |
| Language: | English English |
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Wolters Kluwer - Medknow Publications Wolters Kluwer India Pvt. Ltd.
2017
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| Online Access: | http://irep.iium.edu.my/56455/ http://irep.iium.edu.my/56455/ http://irep.iium.edu.my/56455/7/56455-Low%20inhibition%20of%20alpha-glucosidase.pdf http://irep.iium.edu.my/56455/8/56455-Low%20inhibition%20of%20alpha-glucosidase_SCOPUS.pdf |
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eprints |
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iium-564552017-09-28T04:11:16Z http://irep.iium.edu.my/56455/ Low inhibition of alpha-glucosidase and xanthine oxidase activities of ethanol extract of Momordica charantia fruit Khatib, Alfi Perumal, Vikneswari Ahmed, Qamar Uddin Uzir, Bisha Fathamah Murugesu, S QP Physiology Objective: To evaluate the α-glucosidase and xanthine oxidase inhibitory activities of different ethanolic and aqueous extracts of Momordica charantia fruit. Materials and Methods: The M. charantia fruits were extracted using different concentrations of ethanol in water (0, 20, 40, 60, 80 and 100 %, v/v). The samples from different ethanolic and aqueous extracts of M. charantia fruit (0, 20, 40, 60 and 100 % ethanol in water [v/v] extracts) were tested for α-glucosidase and xanthine oxidase inhibitory activities. Quercetin and allopurinol were used as positive controls for α-glucosidase and xanthine oxidase inhibitory assay, respectively. The samples were also tested for phytochemicals screening such as alkaloid, phenol, steroid, tannin, coumarins and flavonoid. The significant difference was determined by one-way ANOVA test with a Tukey comparison at confidence interval of 95%. Results: Phytochemical screening showed the presence of coumarin, alkaloid, steroid and phenol in the extracts. The six different M. charantia extracts showed low inhibition on α-glucosidase and xanthine oxidase activities. Conclusions: The antidiabetic activity of the ethanolic and aqueous extracts of M. charantia fruit was not through the inhibition of α-glucosidase and xanthine oxidase. Wolters Kluwer - Medknow Publications Wolters Kluwer India Pvt. Ltd. 2017 Article PeerReviewed application/pdf en http://irep.iium.edu.my/56455/7/56455-Low%20inhibition%20of%20alpha-glucosidase.pdf application/pdf en http://irep.iium.edu.my/56455/8/56455-Low%20inhibition%20of%20alpha-glucosidase_SCOPUS.pdf Khatib, Alfi and Perumal, Vikneswari and Ahmed, Qamar Uddin and Uzir, Bisha Fathamah and Murugesu, S (2017) Low inhibition of alpha-glucosidase and xanthine oxidase activities of ethanol extract of Momordica charantia fruit. Journal of Pharmaceutical Negative Results, 8 (1). pp. 20-24. ISSN 0976-9234 E-ISSN 2229-7723 http://www.pnrjournal.com/temp/JPharmNegativeResults8120-1605037_002645.pdf |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English English |
| topic |
QP Physiology |
| spellingShingle |
QP Physiology Khatib, Alfi Perumal, Vikneswari Ahmed, Qamar Uddin Uzir, Bisha Fathamah Murugesu, S Low inhibition of alpha-glucosidase and xanthine oxidase activities of ethanol extract of Momordica charantia fruit |
| description |
Objective: To evaluate the α-glucosidase and xanthine oxidase inhibitory activities of
different ethanolic and aqueous extracts of Momordica charantia fruit. Materials and
Methods: The M. charantia fruits were extracted using different concentrations of ethanol
in water (0, 20, 40, 60, 80 and 100 %, v/v). The samples from different ethanolic and
aqueous extracts of M. charantia fruit (0, 20, 40, 60 and 100 % ethanol in water [v/v]
extracts) were tested for α-glucosidase and xanthine oxidase inhibitory activities. Quercetin
and allopurinol were used as positive controls for α-glucosidase and xanthine oxidase
inhibitory assay, respectively. The samples were also tested for phytochemicals screening
such as alkaloid, phenol, steroid, tannin, coumarins and flavonoid. The significant difference
was determined by one-way ANOVA test with a Tukey comparison at confidence interval
of 95%. Results: Phytochemical screening showed the presence of coumarin, alkaloid,
steroid and phenol in the extracts. The six different M. charantia extracts showed low
inhibition on α-glucosidase and xanthine oxidase activities. Conclusions: The antidiabetic
activity of the ethanolic and aqueous extracts of M. charantia fruit was not through the
inhibition of α-glucosidase and xanthine oxidase. |
| format |
Article |
| author |
Khatib, Alfi Perumal, Vikneswari Ahmed, Qamar Uddin Uzir, Bisha Fathamah Murugesu, S |
| author_facet |
Khatib, Alfi Perumal, Vikneswari Ahmed, Qamar Uddin Uzir, Bisha Fathamah Murugesu, S |
| author_sort |
Khatib, Alfi |
| title |
Low inhibition of alpha-glucosidase and xanthine
oxidase activities of ethanol extract of Momordica
charantia fruit |
| title_short |
Low inhibition of alpha-glucosidase and xanthine
oxidase activities of ethanol extract of Momordica
charantia fruit |
| title_full |
Low inhibition of alpha-glucosidase and xanthine
oxidase activities of ethanol extract of Momordica
charantia fruit |
| title_fullStr |
Low inhibition of alpha-glucosidase and xanthine
oxidase activities of ethanol extract of Momordica
charantia fruit |
| title_full_unstemmed |
Low inhibition of alpha-glucosidase and xanthine
oxidase activities of ethanol extract of Momordica
charantia fruit |
| title_sort |
low inhibition of alpha-glucosidase and xanthine
oxidase activities of ethanol extract of momordica
charantia fruit |
| publisher |
Wolters Kluwer - Medknow Publications Wolters Kluwer India Pvt. Ltd. |
| publishDate |
2017 |
| url |
http://irep.iium.edu.my/56455/ http://irep.iium.edu.my/56455/ http://irep.iium.edu.my/56455/7/56455-Low%20inhibition%20of%20alpha-glucosidase.pdf http://irep.iium.edu.my/56455/8/56455-Low%20inhibition%20of%20alpha-glucosidase_SCOPUS.pdf |
| first_indexed |
2023-09-18T21:19:39Z |
| last_indexed |
2023-09-18T21:19:39Z |
| _version_ |
1777411796448051200 |