MIGRS 13-01-001-0008 Fusion prophetic medicine (honey) and contemporary medicine (paracetamol) as a future greener pharmaceutical

Paracetamol or acetaminophen is a common analgesic and antipyretic drug used worldwide which available in various dosage forms such as tablet, syrup and suspension. Paracetamol suspension available in the market contains high amount of sugar to mask the bitter taste of paracetamol. High sugar conten...

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Main Authors:	Mohamed, Farahidah, Haris, Muhammad Salahuddin, Mohd Shafri, Mohd Affendi, Doolaanea, Abd Almonem
Format:	Monograph
Language:	English English
Published:	2017
Subjects:	RM Therapeutics. Pharmacology RM300 Drugs and their action RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/56467/ http://irep.iium.edu.my/56467/1/Research%20Report%20MIGRS.docx http://irep.iium.edu.my/56467/3/End%20of%20Project%20Report%20MIGRS%2013-01-001-0008.docx

id	iium-56467
recordtype	eprints
spelling	iium-564672018-05-03T06:33:30Z http://irep.iium.edu.my/56467/ MIGRS 13-01-001-0008 Fusion prophetic medicine (honey) and contemporary medicine (paracetamol) as a future greener pharmaceutical Mohamed, Farahidah Haris, Muhammad Salahuddin Mohd Shafri, Mohd Affendi Doolaanea, Abd Almonem RM Therapeutics. Pharmacology RM300 Drugs and their action RS Pharmacy and materia medica Paracetamol or acetaminophen is a common analgesic and antipyretic drug used worldwide which available in various dosage forms such as tablet, syrup and suspension. Paracetamol suspension available in the market contains high amount of sugar to mask the bitter taste of paracetamol. High sugar content especially sucrose will lead to health problems such as dental caries especially in children who frequently have fever and colds. This study aims to explore the potential of honey to substitute sugar in paracetamol suspension. Honey is widely known as a natural sweetener. Besides, it contains micronutrients such as vitamins and enzymes that give a wholesome benefit such as antibacterial and antifungal properties. Compatibility study was performed on the API and each excipient binary mixture using differential scanning calorimetry (DSC) and supported by attenuated total reflectance (ATR). Characterisation of paracetamol honey suspension was done such as particle size, particle size distribution, zeta potential, pH and viscosity. Analgesic and antipyretic activities of the suspension compared to Panadol® were also performed on rats. Analytical methods verification of paracetamol honey suspension and 4-aminophenol were performed using HPLC. Paracetamol honey suspension was scaled up to 500 litres to identify optimum process parameters in order to manufacture a quality suspension. Samples from scale up process were taken and stored in both real time and accelerated stability chambers for stability study. Once the optimum process parameters were identified, process validation of paracetamol honey suspension was performed. All required documents were sent to National Pharmaceutical Regulatory Agency (NPRA). The paracetamol honey suspension was successfully manufactured for commercialisation. The suspension met all the compendial specification and was safe, effective and quality. 2017-04-13 Monograph NonPeerReviewed application/pdf en http://irep.iium.edu.my/56467/1/Research%20Report%20MIGRS.docx application/pdf en http://irep.iium.edu.my/56467/3/End%20of%20Project%20Report%20MIGRS%2013-01-001-0008.docx Mohamed, Farahidah and Haris, Muhammad Salahuddin and Mohd Shafri, Mohd Affendi and Doolaanea, Abd Almonem (2017) MIGRS 13-01-001-0008 Fusion prophetic medicine (honey) and contemporary medicine (paracetamol) as a future greener pharmaceutical. Research Report. UNSPECIFIED. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RM Therapeutics. Pharmacology RM300 Drugs and their action RS Pharmacy and materia medica
spellingShingle	RM Therapeutics. Pharmacology RM300 Drugs and their action RS Pharmacy and materia medica Mohamed, Farahidah Haris, Muhammad Salahuddin Mohd Shafri, Mohd Affendi Doolaanea, Abd Almonem MIGRS 13-01-001-0008 Fusion prophetic medicine (honey) and contemporary medicine (paracetamol) as a future greener pharmaceutical
description	Paracetamol or acetaminophen is a common analgesic and antipyretic drug used worldwide which available in various dosage forms such as tablet, syrup and suspension. Paracetamol suspension available in the market contains high amount of sugar to mask the bitter taste of paracetamol. High sugar content especially sucrose will lead to health problems such as dental caries especially in children who frequently have fever and colds. This study aims to explore the potential of honey to substitute sugar in paracetamol suspension. Honey is widely known as a natural sweetener. Besides, it contains micronutrients such as vitamins and enzymes that give a wholesome benefit such as antibacterial and antifungal properties. Compatibility study was performed on the API and each excipient binary mixture using differential scanning calorimetry (DSC) and supported by attenuated total reflectance (ATR). Characterisation of paracetamol honey suspension was done such as particle size, particle size distribution, zeta potential, pH and viscosity. Analgesic and antipyretic activities of the suspension compared to Panadol® were also performed on rats. Analytical methods verification of paracetamol honey suspension and 4-aminophenol were performed using HPLC. Paracetamol honey suspension was scaled up to 500 litres to identify optimum process parameters in order to manufacture a quality suspension. Samples from scale up process were taken and stored in both real time and accelerated stability chambers for stability study. Once the optimum process parameters were identified, process validation of paracetamol honey suspension was performed. All required documents were sent to National Pharmaceutical Regulatory Agency (NPRA). The paracetamol honey suspension was successfully manufactured for commercialisation. The suspension met all the compendial specification and was safe, effective and quality.
format	Monograph
author	Mohamed, Farahidah Haris, Muhammad Salahuddin Mohd Shafri, Mohd Affendi Doolaanea, Abd Almonem
author_facet	Mohamed, Farahidah Haris, Muhammad Salahuddin Mohd Shafri, Mohd Affendi Doolaanea, Abd Almonem
author_sort	Mohamed, Farahidah
title	MIGRS 13-01-001-0008 Fusion prophetic medicine (honey) and contemporary medicine (paracetamol) as a future greener pharmaceutical
title_short	MIGRS 13-01-001-0008 Fusion prophetic medicine (honey) and contemporary medicine (paracetamol) as a future greener pharmaceutical
title_full	MIGRS 13-01-001-0008 Fusion prophetic medicine (honey) and contemporary medicine (paracetamol) as a future greener pharmaceutical
title_fullStr	MIGRS 13-01-001-0008 Fusion prophetic medicine (honey) and contemporary medicine (paracetamol) as a future greener pharmaceutical
title_full_unstemmed	MIGRS 13-01-001-0008 Fusion prophetic medicine (honey) and contemporary medicine (paracetamol) as a future greener pharmaceutical
title_sort	migrs 13-01-001-0008 fusion prophetic medicine (honey) and contemporary medicine (paracetamol) as a future greener pharmaceutical
publishDate	2017
url	http://irep.iium.edu.my/56467/ http://irep.iium.edu.my/56467/1/Research%20Report%20MIGRS.docx http://irep.iium.edu.my/56467/3/End%20of%20Project%20Report%20MIGRS%2013-01-001-0008.docx
first_indexed	2023-09-18T21:19:41Z
last_indexed	2023-09-18T21:19:41Z
_version_	1777411797890891776

MIGRS 13-01-001-0008 Fusion prophetic medicine (honey) and contemporary medicine (paracetamol) as a future greener pharmaceutical

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