Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity

Herein we report for the first time a series of 2-benzamido-N-(2-oxo-4-(methyl/trifluoromethyl)-2H-chromen-7-yl) benzamide 3a–f and substituted quinazolin-4(3H)-ones and 2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxides (5, 6, 8 and 10a–c) as selective inhibitors of the tumor associated hCA IX and...

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Main Authors:	Bozdag, Murat, Alafeefy, Ahmed Mahmoud, Altamimi, Abdul Malik, Vullo, Daniela, Carta, Fabrizio, Supuran,, Claudiu T.
Format:	Article
Language:	English English English
Published:	Elsevier Ltd 2017
Subjects:	Q Science (General) RC Internal medicine RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/56574/ http://irep.iium.edu.my/56574/ http://irep.iium.edu.my/56574/ http://irep.iium.edu.my/56574/1/56574_Coumarins%20and%20other%20fused%20bicyclic_text.pdf http://irep.iium.edu.my/56574/2/56574_Coumarins%20and%20other%20fused%20bicyclic_SCOPUS.pdf http://irep.iium.edu.my/56574/13/56574_Coumarins%20and%20other%20fused%20bicyclic%20heterocycles_WOS.pdf

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spelling	iium-565742018-03-13T01:18:58Z http://irep.iium.edu.my/56574/ Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity Bozdag, Murat Alafeefy, Ahmed Mahmoud Altamimi, Abdul Malik Vullo, Daniela Carta, Fabrizio Supuran,, Claudiu T. Q Science (General) RC Internal medicine RM Therapeutics. Pharmacology Herein we report for the first time a series of 2-benzamido-N-(2-oxo-4-(methyl/trifluoromethyl)-2H-chromen-7-yl) benzamide 3a–f and substituted quinazolin-4(3H)-ones and 2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxides (5, 6, 8 and 10a–c) as selective inhibitors of the tumor associated hCA IX and XII isoforms. Among the compounds reported the trifluoromethyl derivative 3d resulted the most potent against these CA isoforms with KIs of 10.9 and 6.7 nM Elsevier Ltd 2017-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/56574/1/56574_Coumarins%20and%20other%20fused%20bicyclic_text.pdf application/pdf en http://irep.iium.edu.my/56574/2/56574_Coumarins%20and%20other%20fused%20bicyclic_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/56574/13/56574_Coumarins%20and%20other%20fused%20bicyclic%20heterocycles_WOS.pdf Bozdag, Murat and Alafeefy, Ahmed Mahmoud and Altamimi, Abdul Malik and Vullo, Daniela and Carta, Fabrizio and Supuran,, Claudiu T. (2017) Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity. Bioorganic and Medicinal Chemistry, 25 (2). pp. 677-683. ISSN 0968-0896 E-ISSN 1464-3391 http://www.sciencedirect.com/science/article/pii/S0968089616311051 10.1016/j.bmc.2016.11.039
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	Q Science (General) RC Internal medicine RM Therapeutics. Pharmacology
spellingShingle	Q Science (General) RC Internal medicine RM Therapeutics. Pharmacology Bozdag, Murat Alafeefy, Ahmed Mahmoud Altamimi, Abdul Malik Vullo, Daniela Carta, Fabrizio Supuran,, Claudiu T. Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity
description	Herein we report for the first time a series of 2-benzamido-N-(2-oxo-4-(methyl/trifluoromethyl)-2H-chromen-7-yl) benzamide 3a–f and substituted quinazolin-4(3H)-ones and 2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxides (5, 6, 8 and 10a–c) as selective inhibitors of the tumor associated hCA IX and XII isoforms. Among the compounds reported the trifluoromethyl derivative 3d resulted the most potent against these CA isoforms with KIs of 10.9 and 6.7 nM
format	Article
author	Bozdag, Murat Alafeefy, Ahmed Mahmoud Altamimi, Abdul Malik Vullo, Daniela Carta, Fabrizio Supuran,, Claudiu T.
author_facet	Bozdag, Murat Alafeefy, Ahmed Mahmoud Altamimi, Abdul Malik Vullo, Daniela Carta, Fabrizio Supuran,, Claudiu T.
author_sort	Bozdag, Murat
title	Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity
title_short	Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity
title_full	Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity
title_fullStr	Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity
title_full_unstemmed	Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity
title_sort	coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity
publisher	Elsevier Ltd
publishDate	2017
url	http://irep.iium.edu.my/56574/ http://irep.iium.edu.my/56574/ http://irep.iium.edu.my/56574/ http://irep.iium.edu.my/56574/1/56574_Coumarins%20and%20other%20fused%20bicyclic_text.pdf http://irep.iium.edu.my/56574/2/56574_Coumarins%20and%20other%20fused%20bicyclic_SCOPUS.pdf http://irep.iium.edu.my/56574/13/56574_Coumarins%20and%20other%20fused%20bicyclic%20heterocycles_WOS.pdf
first_indexed	2023-09-18T21:19:49Z
last_indexed	2023-09-18T21:19:49Z
_version_	1777411806867750912

Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity

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