Assessment of Cox2 and CMV in patients with chronic HCV infection
Objective This study was established to determine the expression of COX-2 and CMV in patients with chronic C infection. Methods A total of 30 formalin-fixed of paraffin-embedded liver samples obtained from patients with chronic hepatitis C infection. In addition, 30 apparently normal liver autopsie...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Nab'a Al-Hayat Foundation for Medical Sciences and Health Care, Iraq
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/56689/ http://irep.iium.edu.my/56689/ http://irep.iium.edu.my/56689/2/Assessment%20of%20Cox2%20and%20CMV%20in%20patients%20with%20chronic%20HCV%20infection.pdf http://irep.iium.edu.my/56689/9/56689_Assessment%20of%20Cox2%20and%20CMV_WOS.pdf |
| Summary: | Objective This study was established to determine the expression of COX-2 and CMV in patients with chronic C infection.
Methods A total of 30 formalin-fixed of paraffin-embedded liver samples obtained from patients with chronic hepatitis C infection. In addition, 30 apparently normal liver autopsies were used as control group used for immunohistochemistry technique (IHC) to study the expression of cyclooxygenase (COX-2) and cytomegalovirus (CMV) in these samples.
Results In current study, the results of expression of COX-2 were found in 25 cases (83.3%) of chronic HCV were strongly positive with a
significant increase at P < 0.001, while the result of CMV expression was detected as brown cytoplasmic membranous staining of cells with
positive CMV expression demonstrated in 21 (70.0%) out of 30 cases of chronic HCV infection cases. All control groups were negative for the expression of COX-2 and CMV.
Conclusion This study concludes that COX-2 and CMV participates in the pathogenesis of chronic HCV infection.
Keywords chronic HCV infection, cyclooxygenase (COX-2), cytomegalovirus (CMV) |
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