Assessment of Cox2 and CMV in patients with chronic HCV infection
Objective This study was established to determine the expression of COX-2 and CMV in patients with chronic C infection. Methods A total of 30 formalin-fixed of paraffin-embedded liver samples obtained from patients with chronic hepatitis C infection. In addition, 30 apparently normal liver autopsie...
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Nab'a Al-Hayat Foundation for Medical Sciences and Health Care, Iraq
2017
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| Online Access: | http://irep.iium.edu.my/56689/ http://irep.iium.edu.my/56689/ http://irep.iium.edu.my/56689/2/Assessment%20of%20Cox2%20and%20CMV%20in%20patients%20with%20chronic%20HCV%20infection.pdf http://irep.iium.edu.my/56689/9/56689_Assessment%20of%20Cox2%20and%20CMV_WOS.pdf |
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iium-566892019-08-20T17:10:08Z http://irep.iium.edu.my/56689/ Assessment of Cox2 and CMV in patients with chronic HCV infection F. Hassan, Heba M. Khashman, Basim A. Abdul Qader, Omer W. Izzat, Alaa RB Pathology Objective This study was established to determine the expression of COX-2 and CMV in patients with chronic C infection. Methods A total of 30 formalin-fixed of paraffin-embedded liver samples obtained from patients with chronic hepatitis C infection. In addition, 30 apparently normal liver autopsies were used as control group used for immunohistochemistry technique (IHC) to study the expression of cyclooxygenase (COX-2) and cytomegalovirus (CMV) in these samples. Results In current study, the results of expression of COX-2 were found in 25 cases (83.3%) of chronic HCV were strongly positive with a significant increase at P < 0.001, while the result of CMV expression was detected as brown cytoplasmic membranous staining of cells with positive CMV expression demonstrated in 21 (70.0%) out of 30 cases of chronic HCV infection cases. All control groups were negative for the expression of COX-2 and CMV. Conclusion This study concludes that COX-2 and CMV participates in the pathogenesis of chronic HCV infection. Keywords chronic HCV infection, cyclooxygenase (COX-2), cytomegalovirus (CMV) Nab'a Al-Hayat Foundation for Medical Sciences and Health Care, Iraq 2017-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/56689/2/Assessment%20of%20Cox2%20and%20CMV%20in%20patients%20with%20chronic%20HCV%20infection.pdf application/pdf en http://irep.iium.edu.my/56689/9/56689_Assessment%20of%20Cox2%20and%20CMV_WOS.pdf F. Hassan, Heba and M. Khashman, Basim and A. Abdul Qader, Omer and W. Izzat, Alaa (2017) Assessment of Cox2 and CMV in patients with chronic HCV infection. Journal of Contemporary Medical Sciences (JOCMS), 3 (9 (Winter)). pp. 182-185. ISSN 2413-0516 E-ISSN 2413-0516 http://www.jocms.org/index.php/jcms/article/view/134 |
| repository_type |
Digital Repository |
| institution_category |
Local University |
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International Islamic University Malaysia |
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IIUM Repository |
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Online Access |
| language |
English English |
| topic |
RB Pathology |
| spellingShingle |
RB Pathology F. Hassan, Heba M. Khashman, Basim A. Abdul Qader, Omer W. Izzat, Alaa Assessment of Cox2 and CMV in patients with chronic HCV infection |
| description |
Objective This study was established to determine the expression of COX-2 and CMV in patients with chronic C infection.
Methods A total of 30 formalin-fixed of paraffin-embedded liver samples obtained from patients with chronic hepatitis C infection. In addition, 30 apparently normal liver autopsies were used as control group used for immunohistochemistry technique (IHC) to study the expression of cyclooxygenase (COX-2) and cytomegalovirus (CMV) in these samples.
Results In current study, the results of expression of COX-2 were found in 25 cases (83.3%) of chronic HCV were strongly positive with a
significant increase at P < 0.001, while the result of CMV expression was detected as brown cytoplasmic membranous staining of cells with
positive CMV expression demonstrated in 21 (70.0%) out of 30 cases of chronic HCV infection cases. All control groups were negative for the expression of COX-2 and CMV.
Conclusion This study concludes that COX-2 and CMV participates in the pathogenesis of chronic HCV infection.
Keywords chronic HCV infection, cyclooxygenase (COX-2), cytomegalovirus (CMV) |
| format |
Article |
| author |
F. Hassan, Heba M. Khashman, Basim A. Abdul Qader, Omer W. Izzat, Alaa |
| author_facet |
F. Hassan, Heba M. Khashman, Basim A. Abdul Qader, Omer W. Izzat, Alaa |
| author_sort |
F. Hassan, Heba |
| title |
Assessment of Cox2 and CMV in patients with chronic HCV infection |
| title_short |
Assessment of Cox2 and CMV in patients with chronic HCV infection |
| title_full |
Assessment of Cox2 and CMV in patients with chronic HCV infection |
| title_fullStr |
Assessment of Cox2 and CMV in patients with chronic HCV infection |
| title_full_unstemmed |
Assessment of Cox2 and CMV in patients with chronic HCV infection |
| title_sort |
assessment of cox2 and cmv in patients with chronic hcv infection |
| publisher |
Nab'a Al-Hayat Foundation for Medical Sciences and Health Care, Iraq |
| publishDate |
2017 |
| url |
http://irep.iium.edu.my/56689/ http://irep.iium.edu.my/56689/ http://irep.iium.edu.my/56689/2/Assessment%20of%20Cox2%20and%20CMV%20in%20patients%20with%20chronic%20HCV%20infection.pdf http://irep.iium.edu.my/56689/9/56689_Assessment%20of%20Cox2%20and%20CMV_WOS.pdf |
| first_indexed |
2023-09-18T21:20:01Z |
| last_indexed |
2023-09-18T21:20:01Z |
| _version_ |
1777411819364679680 |