The effects of Eurycoma longifolia on testosterone and blood pressure in high-fat-Fed animal model

There is increased prevalence of hypertensives among Malaysians in the last decade. The cost of antihypertensive agents is also escalating. There is a dire need for cheaper alternative drugs. In tropical regions, there have been claims that Eurycoma longifolia (EL) a local herbal plant is effectiv...

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Main Authors:	Mokhtar, Rafidah Hanim, Al-Joufi, Fakhria, Saxena, Anil Kumar, Al-Ani, Imad Matloub Dally, A.Talib, Norlelawati, Ku-Zaifah, Norsidah
Format:	Article
Language:	English English
Published:	2017
Subjects:	QP Physiology R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/56866/ http://irep.iium.edu.my/56866/ http://irep.iium.edu.my/56866/ http://irep.iium.edu.my/56866/1/Effects%20of%20Eurycoma%20longifolia%20on%20Testosterone.pdf http://irep.iium.edu.my/56866/7/56886_The%20effects%20of%20Eurycoma%20longifolia%20on%20testosterone_Scopus.pdf

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spelling	iium-568662017-06-06T07:38:50Z http://irep.iium.edu.my/56866/ The effects of Eurycoma longifolia on testosterone and blood pressure in high-fat-Fed animal model Mokhtar, Rafidah Hanim Al-Joufi, Fakhria Saxena, Anil Kumar Al-Ani, Imad Matloub Dally A.Talib, Norlelawati Ku-Zaifah, Norsidah QP Physiology R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica There is increased prevalence of hypertensives among Malaysians in the last decade. The cost of antihypertensive agents is also escalating. There is a dire need for cheaper alternative drugs. In tropical regions, there have been claims that Eurycoma longifolia (EL) a local herbal plant is effective in obliterating headache and reducing blood pressure. Most studies had focused on aphrodisiac property of EL which has been shown to enhance testosterone levels in males. This study exploredthe possible effect of EL as an anti-hypertensive agent and whether the mechanism is related to serum testosterone levels. Twenty four healthy male Sprague-Dawley rats were randomly divided into four groups (n=6): normal diet (ND), normal diet treated with EL (NDEL), high-fat diet (HFD) and HFD treated with EL (HFDEL). EL (15 mg/kg) was administered orally for 12 weeks. The animal’s body weight, blood pressure and testosterone level were measured at week 0, 6 and 12.Results showed that the level of testosterone in groups receiving EL were significantly increased (P<0.05) from the untreated groups, in agreement with previous studies report on EL increasing testosterone level. Rats with high fat diet benefitted from treatment with EL extract (HFDEL)as there were reduced systolic and diastolic blood pressure significantly (P<0.05). Despite this effect, there were no significant correlations between blood pressure and testosterone level in HFDEL. There were no changes of blood pressure in rats receiving normal diet with or without EL, but there was a significant negative correlation (r= -0.846, p=0.034) between testosterone and diastolic blood pressure in NDEL. This study suggested the presence of anti-hypertensive property of EL in high fat diet induced hypertension, but it not associated with testosterone level. The blood pressure lowering 2017-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/56866/1/Effects%20of%20Eurycoma%20longifolia%20on%20Testosterone.pdf application/pdf en http://irep.iium.edu.my/56866/7/56886_The%20effects%20of%20Eurycoma%20longifolia%20on%20testosterone_Scopus.pdf Mokhtar, Rafidah Hanim and Al-Joufi, Fakhria and Saxena, Anil Kumar and Al-Ani, Imad Matloub Dally and A.Talib, Norlelawati and Ku-Zaifah, Norsidah (2017) The effects of Eurycoma longifolia on testosterone and blood pressure in high-fat-Fed animal model. Journal of Applied Pharmaceutical Science, 7 (4). pp. 119-124. ISSN 2231-3354 http://japsonline.com/admin/php/uploads/2231_pdf.pdf 10.7324/JAPS.2017.70417
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QP Physiology R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica
spellingShingle	QP Physiology R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica Mokhtar, Rafidah Hanim Al-Joufi, Fakhria Saxena, Anil Kumar Al-Ani, Imad Matloub Dally A.Talib, Norlelawati Ku-Zaifah, Norsidah The effects of Eurycoma longifolia on testosterone and blood pressure in high-fat-Fed animal model
description	There is increased prevalence of hypertensives among Malaysians in the last decade. The cost of antihypertensive agents is also escalating. There is a dire need for cheaper alternative drugs. In tropical regions, there have been claims that Eurycoma longifolia (EL) a local herbal plant is effective in obliterating headache and reducing blood pressure. Most studies had focused on aphrodisiac property of EL which has been shown to enhance testosterone levels in males. This study exploredthe possible effect of EL as an anti-hypertensive agent and whether the mechanism is related to serum testosterone levels. Twenty four healthy male Sprague-Dawley rats were randomly divided into four groups (n=6): normal diet (ND), normal diet treated with EL (NDEL), high-fat diet (HFD) and HFD treated with EL (HFDEL). EL (15 mg/kg) was administered orally for 12 weeks. The animal’s body weight, blood pressure and testosterone level were measured at week 0, 6 and 12.Results showed that the level of testosterone in groups receiving EL were significantly increased (P<0.05) from the untreated groups, in agreement with previous studies report on EL increasing testosterone level. Rats with high fat diet benefitted from treatment with EL extract (HFDEL)as there were reduced systolic and diastolic blood pressure significantly (P<0.05). Despite this effect, there were no significant correlations between blood pressure and testosterone level in HFDEL. There were no changes of blood pressure in rats receiving normal diet with or without EL, but there was a significant negative correlation (r= -0.846, p=0.034) between testosterone and diastolic blood pressure in NDEL. This study suggested the presence of anti-hypertensive property of EL in high fat diet induced hypertension, but it not associated with testosterone level. The blood pressure lowering
format	Article
author	Mokhtar, Rafidah Hanim Al-Joufi, Fakhria Saxena, Anil Kumar Al-Ani, Imad Matloub Dally A.Talib, Norlelawati Ku-Zaifah, Norsidah
author_facet	Mokhtar, Rafidah Hanim Al-Joufi, Fakhria Saxena, Anil Kumar Al-Ani, Imad Matloub Dally A.Talib, Norlelawati Ku-Zaifah, Norsidah
author_sort	Mokhtar, Rafidah Hanim
title	The effects of Eurycoma longifolia on testosterone and blood pressure in high-fat-Fed animal model
title_short	The effects of Eurycoma longifolia on testosterone and blood pressure in high-fat-Fed animal model
title_full	The effects of Eurycoma longifolia on testosterone and blood pressure in high-fat-Fed animal model
title_fullStr	The effects of Eurycoma longifolia on testosterone and blood pressure in high-fat-Fed animal model
title_full_unstemmed	The effects of Eurycoma longifolia on testosterone and blood pressure in high-fat-Fed animal model
title_sort	effects of eurycoma longifolia on testosterone and blood pressure in high-fat-fed animal model
publishDate	2017
url	http://irep.iium.edu.my/56866/ http://irep.iium.edu.my/56866/ http://irep.iium.edu.my/56866/ http://irep.iium.edu.my/56866/1/Effects%20of%20Eurycoma%20longifolia%20on%20Testosterone.pdf http://irep.iium.edu.my/56866/7/56886_The%20effects%20of%20Eurycoma%20longifolia%20on%20testosterone_Scopus.pdf
first_indexed	2023-09-18T21:20:17Z
last_indexed	2023-09-18T21:20:17Z
_version_	1777411836162867200

The effects of Eurycoma longifolia on testosterone and blood pressure in high-fat-Fed animal model

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